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Powder pressing

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

Baking powder is perhaps the best-known secret of baking. The leavening agent forms bubbles in dough and batter to give muffins, cakes, and no-yeast pizza their tempting lift. First developed in the 19th century, baking powder production turned baking into the home activity we know today.

Baking powder

Chili powder

Curry powder

The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.

Dry inhaler powder

If you want to make your eyes more attractive and add depth and dimension to them, applying color to your lids is what it takes. Eyeshadow serves this purpose and is available in powder, liquid, pencil and mousse form. In an eyeshadow production line, compact eyeshadows are produced by grinding and mixing powders before compaction, whereas molded eyeshadows are made from waxes and oils mixed with pigments and then poured into molds. Instead, by mixing oils, gelling agents, elastomers, and pigments you can make a mousse eyeshadow.

Eyeshadow

Looking beautiful is hard work. Queen Elizabeth I knows this well. Just think she used so many cosmetics and makeup containing toxic materials, especially lead-based face powder, that she even died from them. Today fortunately, you no longer need lead to make face powder. Simply mix pigments, fillers, dry and wet binders, and compress the mixture using a powder compacting press. Then the face powder is ready to be applied using a powder puff.

Face powder

Flour processing technology has changed drastically since the days of the millstone pulled by a mule. But demand for more refined flour means that the production process is now slower than with more rudimentary techniques. When mixed with water, protein in wheat flour form an elastic gluten structure, giving bakery products their irresistible fluffiness.

Flour

Food powder is the result of drying and pulverizing food. It has been around since the astronauts when out to space. Fruits have a short shelf life and are difficult to preserve due to their high water content.  Fruit powder processing allows you to keep the nutrients of the fruits for a longer time, even off-season.

Fruit powder

In 1682, Denis Papin found a method to remove collagen from animal bones, discovering gelatin. But it was the inventor Peter Cooper who developed gelatin powder processing. In 1845 he secured his invention with US patent 4084 for a dessert of gelatin powder called “portable gelatin”.

Gelatin powder

<span style="font-weight: 400;">Any coffee-drinker can agree that a cup of coffee in the morning can brighten up their day. As the most convenient way of making coffee, many people choose to make coffee at home. Whether you want to make Moka coffee or filtered coffee, you need ground coffee that is grind appropriately for the coffee brewing method of your choice. These ground coffee are manufactured by roasting and grinding processes. </span>

Ground coffee

Gypsum is a naturally occurring mineral that serves many purposes, with the United States producing the largest crude gypsum in the world. Cover walls, ceilings, plasters, fertilizers, cosmetics and some foods: gypsum’s vast applications granted it the recognition of "wonder mineral". Gypsum making equipment helps in making gypsum powder or board for industrial use.

Gypsum

Do you know that the famous classical music composer and pianist Ludwig van Beethoven insisted on drinking a cup of coffee made from exactly 60 pieces of coffee beans? Currently, around 50% of the world’s green coffee beans undergo processing through instant coffee manufacturing equipment to produce instant coffee. The process requires roasting, grinding, brewing, and heating to obtain the extract; the coffee extract will either go through a spray drying process or a freeze-drying process.

Instant coffee

Instant soup is quite popular due to its ease of use and quick preparation. Products like cup noodles and vegetable soup mixes are some of the examples commonly used by consumers. The instant soup processing equipment is used to dehydrate or dry components of the soup mixture to prolong shelf life and preserve the taste of the vegetables and other components.

Instant soup

Forged metal objects appear seamless, simple items. But as the use of metals changed over time and constructions became more intricate with additive manufacturing, a new way of processing materials surfaced. Metal powder manufacturing replaces the classic blacksmithing techniques, reducing scrap waste in the meantime. The final metal products, however, retain that shiny allure of the archetypal metal pieces.

Metal powder

Basically, to make milk powder, you need to remove the water content from the liquid milk and turn it into powder. How to do it? After pasteurizing and homogenizing the milk, milk’s water content is removed through filtration, evaporation, and drying. You have then to cool and sieve it before filling the containers. Here's how you get milk powder.

Milk powder

Powder detergent is one of the most widespread washing solutions used in the laundry of fabrics. Since they contain no water, powder detergents are lighter than liquid detergent or pods, which results in cheaper transport and, thus, a more affordable choice for the end consumer. Although manufacturers can formulate their powder detergents differently, the detergent powder production process relies on a combination of builders, surfactants, and enzymes.

Powder detergent

It took the scientific community almost 70 years to agree on the name ‘protein’ and discard the popular alternative, proteid. But protein powder processing still needed another five decades to be commercialized in the 1950s. Once extraction and purification could be industrialized, protein powder soon became a basic staple supplement.

Protein powder

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

There are slight differences between human and animal pharmaceuticals, but that dissimilarity is enough to create new production challenges. Veterinary tablets formulation reflects the diversity of enzymes that different species use to break down substances. Although the methods involved are comparable to human drug manufacturing, equipment and processes need to adapt to a wider dosage variability in veterinary tablets.

Veterinary tablets

The wave of liquid soaps and detergents in the 1950s revolutionized home and personal care. Cheap and convenient, these off-the-shelf products fit perfectly into the lifestyle of the time. A few decades later, though, plastic waste put the sustainability of hygiene products into question. Refill tablet production technology answers that by eliminating single-use plastic. Instead of picking up a new bottle every time, end-users complete the formulation process in a multi-use container and with a simple instruction: just add water.

Refill tablets

High speed, high efficiency volume tablet press

Disk interchange system allows quick changeover

Can produce a wide variety of dosage forms

Optional tablet weight control system available

Efficient operation with a small footprint

A tablet press consists of two essential tools, namely dies and punches. It compresses powder or granules into a desired solid substance of uniform size and weight. After filling the dies with powder or granules, upper and lower punches are pressed together within the die hole to form tablets. Then the upper punches come back to their original position while the lower punches help the ejection of the tablet from the dies.

Tablet presses

Pharmaceutical

Pressing

Connect directly with world leading manufacturers of Pressing equipment and find technology to build or improve your production line.

Pressing &#8211; Making.com

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Process

R&amp;D

Batch

Compaction machines and technologies crush or compress materials and make them denser. Compaction can be used to simply save space or to shape materials into a desired form or format. Tablets, pellets, or briquets are formed by compactors but powder presses also help form cosmetic eyeshadow or face powder.

Compaction

The process of forming allows you to shape your products homogeneously. Forming machines are fed the manufactured material in bulk and cut it down to specification, so the process takes place between formulation of the mass and the packaging of the final item.

A special class of this equipment – Form, Fill, and Seal Machines (FFS) – creates bags and pouches from flat material such as plastic sheets, fills them with your designated product, and seals them.

Forming

solid

For pharmaceutical tablet producers looking to reduce waste, costs and  increase production volume, a high efficiency rotary tablet press is the ideal

Rotary tablet press &#8211; Making.com

We open production technology to everyone

Making.com

Vitamin C is an essential nutrient, but the human species lost the ability to produce it biologically during the course of evolution. Instead, we source the substance either from whole foods or vitamin C manufacturing. The chemical characteristics of the natural nutrient and processed compound are the same, but supplements offer higher concentrations, especially to persons with nutrient deficiencies.

Vitamin C

Flexible tablet presses for medium volume production with features designed for reduced maintenance

High speed and high pressure for superior results

Comprehensive HMI with simple controls and full 21CFR part 11 reporting

Round or oblong tablet production with turret interchange

Up to 30% productivity increase over previous generation machines

High performance tablet presses for the modern production environment need to be fast, accurate and flexible. Rapid changeover, simple operation and high

Single layer tablet press &#8211; Making.com

High capacity, fully flexible tablet presses with features designed for reduced maintenance

Double-layer capable with first layer sampling

30% productivity increase over previous generation machine

High performance tablet presses that are capable of producing both single and double-layer tablets offer the maximum flexibility to a multi-product

Single and double layer tablet press &#8211; Making.com

acg-pam-protab-brochure-pdf

ACG-Pam-Protab-brochure.pdf

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

Suppositories consist of active pharmaceutical ingredients encased in a non-active base material. The sustained release of medication makes suppositories a preferred option for the long-term treatment of chronic conditions like diabetes, anemia, and AIDS.

Suppositories

A dishwasher tablet is an essential detergent. It consists of a pressed mixture of sodium and potassium salts, surfactant, fragrance, and other filler agents, mixed with the help of tablet making machines. The products’ use in America and Europe is high, unlike in the Asian continent, where the price limits its usage. Its global market size will reach $990 million in 2026 from $475.6million in 2019, according to Grand View Research forecasts.

Dishwasher tablets

Easy access to all important areas

Minimal product loss

Instant detection of faulty punches during operation

Lightweight assemblies and peripherals designed for easy removal

Mechanical changeover in 30 minutes

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Packaging

Continuous

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

The Protab 300 from ACG Pam is a simplified rotary tablet press designed for small and medium batch pharmaceutical producers.

Creating batches of consistent high quality pharmaceutical grade tablets from your powdered ingredients requires equipment that complies with strict

Single rotary tablet press &#8211; Making.com

brochure_multigel_tabletpress-pdf

Brochure_Multigel_TabletPress.pdf

Lab-scale tablet press with robust, high-quality construction for longevity

No special installation, single-phase electricity only required

Adjustable tablet diameter and variety of punch shapes for flexibility

Simple control with in-built counter for accurate batch monitoring

Product contact pathway all stainless steel for easy cleaning

For lab work or small-scale production, a purpose-designed tablet press that meets your exact requirements offers distinct benefits in terms of economic

Benchtop tablet press &#8211; Making.com

brochure_kikusui_high-speed-tablet-press-pdf

Brochure_Kikusui_high-speed-tablet-press.pdf

Turret exchanges within 20 minutes reduce downtime

5 Kw electric motor delivers high production volumes

Head guard, dust seals and bellows control lost powder

Enclosed feeder and vacuum suction minimise powder loss

High speed pharmaceutical tablet presses convert powder to tablets. The operations should be quick and simple, and deliver high volumes with low

High Speed Tablet Press &#8211; Making.com

Production machine quality from laboratory-scale equipment

High quality tablet samples from small amounts of granules

Capable of scaling up to 28,800 tablets per hour

Pharmaceutical research and development projects may require small samples of high quality tablets for testing. Laboratory tablet presses must have full

Laboratory Tablet Press &#8211; Making.com

brochure_bonals_be40

Brochure_Bonals_BE40

Powder aspiration system

Quick change over, less than10 minutes

Easy adjustment of compression speed

Minimal powder waste

Small and medium batch capacity  

Chemical tablet formulas allow granules to break away under the conditions you would have designed them for. Powder presses distribute particles from the stock material evenly onto molds and subject the it to pressure to produce a dense block. Powder tablets often include a precise mixture of products and presses combine the correct dosage to form multi-layered slabs ready for packaging.

Powder presses

Chemical

Cosmetic

According to a legend, Cleopatra soaked her sails in her perfume so that Mark Antony could smell her ships before they arrived. This is to say that, from soaps and shampoos to perfumes, conditioners and pomades, cosmetics have always been highly valued and used for their properties of aesthetic enhancement. Cosmetics are a broad class of topical agents applied for various purposes such as cleansing, protecting, beautifying, or otherwise altering your appearance. As a result, a wide array of processing equipment is used in the cosmetics industry.

Cosmetics

Detergents are cleaning agents that help remove dirt and grease from porous and non-porous surfaces. Industrial production of detergents began after World War I. Still, it was after the 1950s and 1960s that the detergent industry grew exponentially due in part to the development of new detergent manufacturing equipment.

Detergents

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Hundreds of different refill tablets, of various shapes or sizes, are on the market today. To get a range of soap, shampoo or lotion tablets, the powdered

Eccentric press for refill tablets &#8211; Making.com

<h3>Crush primary materials to free valuable grains from impurities</h3>
The first step to pulverizing a solid is through a crusher. The raw material is downsized to flakes, chips, or granules by crushing technology. Some bulk types, such as plastics or resins, are broken down into filaments.

Crushing breaks the grains away from gangue materials, particularly in the case of ore. Undesired compounds such as common silicate and carbonates are removed using separation technology like magnetic separators for metals and froth flotation for hydrophobics.

One of the main attributes of powders is flowability. Dry materials with a similar particle structure flow more easily than powders of different shapes. However, size is also an important variable in industrial powder handling.

Flowability decreases with the particle size as powders display greater <a href="https://www.shear-test.com/doc/arching_and_ratholing_in_silos.php">cohesion and internal friction</a> the smaller they become. To prevent ratholes or bridging and facilitate flow, advanced manufacturing equipment applies anti-clogging systems. These powder processing systems and techniques are designed to move fine to ultra-fine bulk in specialized powder applications from <a href="https://making.com/products/pharmaceutical-powders">pharmaceuticals</a> to <a href="https://making.com/products/food">food</a> to <a href="https://making.com/face-powder">cosmetics</a>.

Use anti-clogging powder process equipment to ensure flowability

<h3>Avoid unwanted agglomeration by coating powders in anti-adherent components</h3>
Manufacturing technology often subjects powders to thermal stresses that could degrade their processability. High pressure friction and heat lead to surface diffusion, bonding particles together.

To prevent such undesired agglomeration, coat the powder particles in an anti-adherent substance like magnesium stearate. The water-insoluble compound is sprayed onto the material in a mixing drum to create a film around the particles.

Mineral and metal powders present unique challenges in terms of processing, particularly when they are comminuted to finer materials. Particles become harder as their surface area increases, making them more challenging to densify.

Ductile metals like aluminum and copper <a href="https://www.sciencedirect.com/book/9781856174220/handbook-of-non-ferrous-metal-powders" target="_blank" rel="noopener">retain plastic deformation properties</a> down to particle sizes of 50-100 nanometers. But beyond that, powders need to be subjected to high temperatures to be effectively compacted.

Heat mineral and metal fine powders to overcome resistance to compaction 

Particles of nanometric scale bond together to form nanopowders. As the ratio between surface area and volume increases, the characteristics of the atoms become more pronounced.

For instance, nanocrystalline materials such as titanium alloys nickel exhibit enhanced hardness and plasticity.  Advancements in powder processing technology allow engineering at the nanoparticle level, opening opportunities for new lightweight materials with solid structural stability.

Reduce powders to their nanostructures to maximize their properties

<h3>Develop nanopowders either by bonding particles or downsizing granules</h3>
There are two ways to approach the <a href="https://sustainable-nano.com/2014/06/10/two-ways-to-make-nanoparticles/" target="_blank" rel="noopener">production of nanopowders</a>: large-to-small or small-to-large. When working with large materials like metals or minerals, the powders are generated by attrition. The techniques here are primarily mechanical, using dry milling equipment like jet mills or roll mills.

If you work with molecules such as sodium, the process goes from small to large by bonding molecules together to form the particle. This involves electromagnetic techniques like electrospinning and electrodepositing.

Powder Manufacturing Equipment

Powder processing technology

Connect with manufacturers of powder processing solutions and find production technology to build or improve your production and manufacturing process.

Powder &#8211; Making.com

Powder Manufacturing Equipment - Making.com

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Incorporating solids into liquids is a critical process in producing paints, coatings, and battery components. But this step raises serious emissions concerns. Pumping the materials from one mixing vessel to the next promotes the release of dust particles and solvents into the air.


<h2>Fully enclosed batch mixing system for paints and coatings</h2>
The CMX 2000 inline mixer from IKA incorporates powders into liquids in an enclosed and complete system. Featuring a dosing feeder for solids and recirculation technology, the solution limits the mixing process to one machine and reduces the potential for emissions.

The multi-level pump is designed to keep high-viscosity materials flowing without leaving deposits in the mixing container. The chemicals are recirculated to ensure consistent blending and prevent the formation of agglomerates in the final mix.

Solid may be fed with a bulk bag unloader, a hopper, sack-emptying boxes, or directly from the bag with a suction lance. The CMX 2000 is available for batch sizes between 2 and 5.000 liters.

Inline solid-liquid mixer for chemicals and paints

Painting as an integral aspect of the human tradition dates to thousand years ago. Of the many properties of the product, the drying time is important to consumers. The thickness of the paint and environmental factors like humidity affect this parameter. Paint manufacturing equipment must include a humidity test chamber to assess the behavior of paint under different weather conditions.

Paint

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Powder pressing

Which powder pressing equipment do you need?

Rotary tablet press

Single layer tablet press

Single and double layer tablet press

Single rotary tablet press

Benchtop tablet press

High Speed Tablet Press

Laboratory Tablet Press

Eccentric press for refill tablets

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