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Cell Culture Filling Equipment

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

High throughput petri dish filling machines are traditionally slow and require a large amount of space to operate. An innovative industrial scale filling solution that has been engineered for both speed and compact size can provide key advantages that will generate an increased return on investment while maintaining the highest quality.
<h2>High volume petri dish filling for multiple dish types</h2>
The MX000 Series of Petri Dish Filling Machines from IQ Designs offers a flexible multiple-dish filling solution designed to deliver high throughput, versatility, ease of use and all while staying in a small footprint. A unique design enables the MX000 series petri dish filling machines to occupy about 50% of the footprint of other petri dish filling machines while having a higher output than all of them.

Available in a range of models to suit your requirements with the volume of 500 to 6,000 units per hour, the MX000 series features a fully enclosed class 100 HEPA filtered drying environment for 100% open lid drying. It provides adjustable drying time, together with a print station and multi-cavity pouring.

Changeable input/head parts and output parts allow the ability to run many dish types on a single machine.  With these tool-less quick and simple change parts, you can and maximize utility and efficiency.

There are many options available to tailor the MX000 series to your exact needs. Some of the options are nozzle heating stations, printing speed stations, bulk loading and packaging options.

Built for durability and reliability, the MX000 series of petri dish filling machines feature 304 stainless and anodized aluminum construction for strength and longevity.

Industrial petri dish filling machine

Test tube filling needs to be accurate and efficient. Moreover, large laboratories test hundreds of samples simultaneously in extensive research. A laboratory test tube filling machine can take care of this task faster, and more accurately than a human assistant can.
<h2>Automatic test tube filling machines for production laboratories</h2>
The IQ-TRX Test Tube FIlling Machines from IQ Designs can fill many of the standard tube sizes on one machine. These innovative designs help eliminate the need for several pieces of equipment. Moreover, the change parts for running multiple tube types on one machine are easy and down without the use of any special tools.

There’s a touch control panel for easy user interface. The test tube caps are fed from an automated cap feeding station, while tubes arrive via a gravity fed hopper. All of the main operations are done in-line with each other and these stations include: An accurate persitcaltice pump delivers the media. Cap tightening station with cap tightening adjustment and verification, and optional labeling or direct printing onto the tube.

The IQ-TRX Test Tube Filling Machine offers optional: pre-flush gassing, labeling of pre-printed labels just below the cap, direct printing on the side of the tube, aseptic enclosure and automatic rack station for loading the finished tubes into the Clients specified racks.

The standard IQ-TRX  can fill a specific tube type 2,500 uph. The machine footprint is approximately: 2.2 meters across by 1.8 meters deep.

Laboratory test tube filling machine

In biopharmaceutical manufacturing, scaling up production while maintaining sterility is crucial. Traditional manual filling methods often fall short in meeting regulatory standards and efficiency requirements, particularly for advanced therapy medicinal products like cell and gene therapies.
<h2>Automate aseptic filling with controlled environment</h2>
The Crystal® L1 is an advanced aseptic filling line designed by Aseptic Technologies. It integrates a robotic platform with an active Restricted-Access Barrier System (RABS), providing a controlled and sterile environment. This system is ideal for scaling up the production of pharmaceuticals, including biotechnological and medicinal products. The Crystal® L1 is compact and capable of processing up to 500 AT-Closed Vials® per hour, with filling volumes ranging from 0.1 ml to 50 ml. It employs high dosing accuracy and is equipped with single-use materials, minimizing cross-contamination and changeover times. Installed and qualified in one week, it complies with CFR 21 part 11 regulations, making it suitable for cGMP manufacturing and ensuring high-quality production standards.

Aseptic filling line for biopharmaceuticals

For high-speed commercial manufacturing of biopharmaceutical products, maintaining sterility and precise filling is crucial. Common challenges include ensuring in-process control, compliance with GMP standards, and flexibility to handle different vial sizes.
<h2>Enables high-speed aseptic vial filling</h2>
The Crystal™ PX Filling Line by Aseptic Technologies is designed to meet the demands of biopharmaceutical manufacturing. Utilizing AT-Closed Vial® technology, this platform ensures 100% in-process control and full GMP compliance. The system offers a flexible capacity, processing up to 180 vials per minute, depending on the configuration. Custom-built according to user specifications, it can be equipped with a safety barrier for high-class cleanroom environments or installed within a Restricted-Access Barrier System (RABS) with H2O2 decontamination. Featuring automated vial loading, it supports filling volumes ranging from 0.1 ml to 50 ml with high accuracy and tool-less format change. The Crystal™ PX Filling Line is ideal for cell and gene therapy products, exosomes, viral vectors, and plasmid DNA, making it a versatile solution for novel biopharmaceuticals.

Aseptic filling line for biopharmaceutical products

In environments where small cGMP batch production is essential, maintaining sterility and speed during the fill and finish process poses significant challenges. Ensuring that components remain free from contamination while achieving rapid cycle times is critical for success.
<h2>Optimize your aseptic filling process</h2>
The spectra M1, offered by Aseptic Technologies in collaboration with SKAN, is an advanced isolated fill & finish unit specifically designed for small cGMP batch production. This system features the highly regarded SKAN nanox® catalyst and skanfog® technology, which work together to ensure fast and safe decontamination cycles. Utilizing the AT-Closed Vial® technology and the M1 Filling Station, the spectra M1 significantly boosts production efficiency by maintaining a closed filling process, which avoids contamination. The filling process accommodates volumes ranging from 0.1 ml to 50 ml and employs a peristaltic pump with an integrated weighing cell for high accuracy. The user can monitor batch status in real-time via the built-in screen, and the overall operation is compliant with CFR21 part 11 standards. Ideal for applications in cell and gene therapy, next-generation biologics, and compounding.

Aseptic filling solution for small cgmp batches

In biotechnical and biopharmaceutical production, ensuring the seamless preparation and transfer of sterile media and buffers is crucial. The industry faces challenges related to maintaining sterility, accurate dosing, and flexible handling of different media types during upstream and downstream processing.
<h2>Secure storage and precise handling of media</h2>
The Media / Buffer Hold solution by Bioengineering is tailored for the secure storage and handling of sterile media, buffers, and corrective agents. With capacities ranging from 0.5 to 20,000 liters, these storage tanks are versatile and designed to accommodate various microbial and cell culture processes. Sterilizable stainless-steel vessels and glass bottles are available to meet diverse volume requirements. Heat-resistant media can be sterilized directly in the tank, while heat-instable media are sterile-filtered post-sterilization. Transfers are efficiently managed through pump or pressure systems, with various control systems ensuring precise dosage and flow rates. The integration with CIP systems simplifies cleaning, making these tanks integral to maintaining process continuity in bioproduction.

Sterile media and buffer storage tanks

When working with Cell and Gene therapies, precise and sterile filling processes are critical. Challenges often include maintaining aseptic conditions, minimizing cell stress, and controlling fill volumes to ensure product integrity.
<h2>Facilitates aseptic filling of cell and gene therapy products</h2>
The ValueCell FILL by Comecer is a semi-automatic filling system specifically designed for the Cell and Gene therapy fields. This system supports downstream aseptic bag filling operations, offering a closed and modular solution. It includes a refrigerated storage area, a distribution rack, and a peristaltic pump filling system, ensuring low shear stress for sensitive products. The ValueCell FILL is compatible with Grade C cleanroom environments, and its reverse pumping feature minimizes product loss. It is equipped with gentle paddle mixers for ensuring a homogeneous mixture and in-line bubble sensors for quality control. The system handles fill volumes ranging from 50 to 250 mL, with a capacity of up to 150 bags per hour. Ideal for dispensing viral vectors, final cell products, intermediates, and media, it also offers scalable batch sizes to match production growth and includes an intuitive touchscreen HMI for easy operation.

Semi-automatic filling system for cell and gene therapy

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Getinge Applikon is the only company that can take you from the initial screening stage to full-scale production using the same platform. This minimizes scale-up risks and guarantees the shortest time to market for your new product development.

How can single use in biotech be sustainable, if you think of all the waste it creates? This might raise questions regarding the environmental impact. Let’s compare the complete life cycle of single-use systems such as tubing, capsule filters, chromatography devices, and bioreactors to their multi-use counterparts in glass or stainless steel and look at the outcome.

<h2>The end-of-life impact of single use tech</h2>
A product life cycle assessment compared single-use technologies to traditional multi use systems on points like resource extraction, processing, manufacturing, all through the end of the product life. Additionally environmental impact factors such as carbon, energy and water footprint were evaluated to paint a complete sustainable picture. Although disposal and waste remains a concern, the study found that this was actually only 1% of the total impact on the environment. Once put into use single use equipment presented a significantly lower impact resulting in <a href="https://cdn.cytivalifesciences.com/dmm3bwsv3/AssetStream.aspx?mediaformatid=10061&amp;destinationid=10016&amp;assetid=16801">a smaller overall end-of-life impact</a>.
<h2>Single use eliminates the need for cleaning in between batches</h2>
The most pressing finding is that the impact of chemicals, high purity waters and heat for cleaning and sterilization in between production batches is very high. Take for example a <a href="https://making.com/equipment/single-use-bioreactor">single use bioreactor</a> as shown in the video below; No need for extensive cleaning before the culture is started or after it’s finished and reducing the risk of cross contamination. Innovative technology such as 3D printing allows to create customizable products, while (re)creating exact replicas and keep desired process environments steady. Now officially stated as the more sustainable choice makes us understand why single systems are on the rise.

[embed]https://www.youtube.com/watch?v=RfPgrgw_wT8[/embed]

Is single use biotech equipment the more sustainable option?

Pharmaceutical

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

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