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Cell Culture Containment Equipment

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space for manipulation with ISO 14644-1 (Class 5) conditions.


<h2>Compact booth that offers easy access to manipulate non-hazardous products</h2>
Mini-H from Telstar Life-Science are Horizontal laminar flow benches which offer the highest product protection versus dust and contamination in an open cabinet for non-hazardous samples such as cell and tissue cultures, food testing preparation, injectable medicine preparation. It also fits for micromechanics, optics and electronics.

The Compact horizontal laminar flow bench comes with HEPA filtered air; it's particle free and flushes the product preparation space with laminar flow, preventing direct or cross-contamination.

Thanks to its very compact size, Telstar Mini-H permits the installation of a product protection cabinet near the place where the product is utilized.

Compact horizontal laminar flow bench

This handy device offers the most advanced features in product-operator protection and user-friendly ergonomics to allow best working conditions and results.


<h2>Protect to the operator, product/materials and environment under class II conditions</h2>
BioULTRA from Telstar Life-Science is a top range class II cabinet aimed to provide protection to the operator, product/materials and environment. It is certified according to European Standard EN 12469 and also meets NSF 49 (class II type A2 /B3) and BS 5726:2005 main requirements. It is suitable for handling pathogenic agents of levels 1, 2 and 3 in the fields of pharmaceutical, academic research centers, biotechnology, hospital and medical labs, QA control labs.

Motorized sash window with inflatable gasket, filter clogging calculation and a simplified fumigation process minimize maintenance cost and time.

Remote PC Ultra logger control suitable for P3 lab.

Microbiological safety cabinet class II

For the manipulation of hazardous substances utilized during the preparation of cytotoxic medicines as prescribed in several European countries.


<h2>Ideal class II configuration for reinforced biosafety and maintenance cost savings</h2>
The CytoUltra from Telstar Life-Science has 3 filters, which third HEPA filter set below the work bench of CytoUltra traps the contaminants thus preventing them from reaching the plenum, the main HEPA filter and the HEPA exhaust filter, such reinforced safety is required for the handling of highly toxic compounds.

Certified EN 12469 Class II and DIN 12980 for Cytotoxics, CytoUltra offers the most advanced features in product and operator protection and in ergonomics to allow best working conditions.

Third HEPA filter stage easily replaced in the unit basement and filter clogging calculation minimize maintenance cost and time. Remote PC Ultra logger control is suitable for P3 lab.

Biosafety cabinet class II for cytotoxic medicines

Ideal for products which have no biological risk but require high sterile conditions.


<h2>Start working in the lab under high sterile conditions</h2>
Sterilator from Telstar Life-Science is a positive-pressure isolator, which provides laminar airflow in the working chamber, making it ideal for products that require high sterile conditions.

This equipment not only provides a high level of containment against external contamination, but avoids the risk of cross contamination as they provide laminar air flow to the working chamber.

Positive pressure isolator

Specially designed for the handling of microbiological agents, when working with indigenous or exotic pathogenic agents that pose a moderately high risk of serious or potentially lethal disease to the operator when inhaled.


<h2>Offering Class III biological safety to operator, product and environment</h2>
The Biological safety cabinet class III from Telstar Life-Science is a laboratory isolator designed according EN 12469, offering an ergonomically designed totally sealed which keep the user completely separated from the product by a physical barrier when total containment and user protection is required.

Series MSC III is a completely gastight cabinet. The dangerous biological agents enter the work area by a hatch, the operator uses gloves (assembled to the front of the cabinet) to research the biological agents. While working, potential contaminated air is controlled by airflow and negative air pressure.

Biological safety cabinet class III

In biotechnical and biopharmaceutical production, ensuring the seamless preparation and transfer of sterile media and buffers is crucial. The industry faces challenges related to maintaining sterility, accurate dosing, and flexible handling of different media types during upstream and downstream processing.
<h2>Secure storage and precise handling of media</h2>
The Media / Buffer Hold solution by Bioengineering is tailored for the secure storage and handling of sterile media, buffers, and corrective agents. With capacities ranging from 0.5 to 20,000 liters, these storage tanks are versatile and designed to accommodate various microbial and cell culture processes. Sterilizable stainless-steel vessels and glass bottles are available to meet diverse volume requirements. Heat-resistant media can be sterilized directly in the tank, while heat-instable media are sterile-filtered post-sterilization. Transfers are efficiently managed through pump or pressure systems, with various control systems ensuring precise dosage and flow rates. The integration with CIP systems simplifies cleaning, making these tanks integral to maintaining process continuity in bioproduction.

Sterile media and buffer storage tanks

In the fields of regenerative medicine and tissue engineering, maintaining aseptic conditions during cell culture is paramount to avoid contamination and ensure successful outcomes. The challenge lies in creating an isolated environment that meets stringent regulatory standards while minimizing human error and operational costs.
<h2>Ensure sterile conditions with automated decontamination</h2>
The Modular Cell Culture Isolator (MCCI) by Comecer is designed to provide a controlled and sterile environment for cell culture processes. With its fully welded enclosure and integrated ventilation system, the MCCI ensures a consistent Class A environment in a more compact footprint than traditional clean rooms. Featuring a top-class sterilization protocol using a VPHP cycle, it minimizes manual interventions, thus reducing the risk of human error. The isolator's ergonomic glove boxes facilitate operator comfort and efficient space utilization. It is equipped with H14 HEPA filters for both intake and exhaust, maximizing particulate control and flexibility in handling hazardous materials. The MCCI's integrated H2O2 gas decontamination system allows for effective sterilization of both the entire internal volume and specific compartments like the transfer hatch. This modular system is ideal for tissue engineering and biotech labs constrained by regulatory bodies such as FDA, EUP, and USP. Additionally, it offers viable and non-viable continuous monitoring, managed by GAMP 5 software and SCADA systems for 21 CFR Part 11 compliance.

Isolator for aseptic cell culture processing

Scaling up mammalian and insect cell cultures in a consistent and contamination-free environment can be challenging, especially when dealing with high-volume requirements and diverse cell types such as suspension, anchorage-dependent, and stem cells.
<h2>Support scalable cell cultivation processes</h2>
The BioBLU® c Single-Use Bioreactors from Eppendorf are rigid-walled stirred-tank bioreactors designed to facilitate the scalable cultivation of human and animal cells. These bioreactors offer a 400-fold cell expansion with a working volume range from 100 mL to 40 L, making them adaptable to various volume requirements. Different versions have been developed to meet the specific needs of suspension cells, anchorage-dependent cells, and stem cells. All BioBLU c bioreactor sizes are equipped with pitched-blade impellers for optimal mixing and mass transfer. The BioBLU 0.3sc, in particular, features an 8-blade impeller optimized for reduced cell settling and low-shear mixing, ideal for stem cell applications. BioBLU bioreactors are compatible with both Eppendorf's small and bench-scale bioprocess controllers as well as selected third-party systems. With non-invasive sensor technology for pH, DO, and temperature, these bioreactors drastically reduce contamination risk. Additional features include a sealed magnetic drive for maintaining sterility and exhaust treatment options.

Single-use bioreactors for mammalian and insect cell cultivation

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Getinge Applikon is the only company that can take you from the initial screening stage to full-scale production using the same platform. This minimizes scale-up risks and guarantees the shortest time to market for your new product development.

How can single use in biotech be sustainable, if you think of all the waste it creates? This might raise questions regarding the environmental impact. Let’s compare the complete life cycle of single-use systems such as tubing, capsule filters, chromatography devices, and bioreactors to their multi-use counterparts in glass or stainless steel and look at the outcome.

<h2>The end-of-life impact of single use tech</h2>
A product life cycle assessment compared single-use technologies to traditional multi use systems on points like resource extraction, processing, manufacturing, all through the end of the product life. Additionally environmental impact factors such as carbon, energy and water footprint were evaluated to paint a complete sustainable picture. Although disposal and waste remains a concern, the study found that this was actually only 1% of the total impact on the environment. Once put into use single use equipment presented a significantly lower impact resulting in <a href="https://cdn.cytivalifesciences.com/dmm3bwsv3/AssetStream.aspx?mediaformatid=10061&amp;destinationid=10016&amp;assetid=16801">a smaller overall end-of-life impact</a>.
<h2>Single use eliminates the need for cleaning in between batches</h2>
The most pressing finding is that the impact of chemicals, high purity waters and heat for cleaning and sterilization in between production batches is very high. Take for example a <a href="https://making.com/equipment/single-use-bioreactor">single use bioreactor</a> as shown in the video below; No need for extensive cleaning before the culture is started or after it’s finished and reducing the risk of cross contamination. Innovative technology such as 3D printing allows to create customizable products, while (re)creating exact replicas and keep desired process environments steady. Now officially stated as the more sustainable choice makes us understand why single systems are on the rise.

[embed]https://www.youtube.com/watch?v=RfPgrgw_wT8[/embed]

Is single use biotech equipment the more sustainable option?

Pharmaceutical

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

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