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Yeast bioprocessing Equipment

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

Ancient civilizations were using yeast as it naturally occurred in bread-making and brewing. But yeast processing equipment wasn't developed and fully commercialized until the end of the 18th century. Today, this industrialized micro-organism is critical in producing biofuels and other products beyond food and drinks.

Yeast

For accurate comparisons of carbon conversion rates and yields for six simultaneous anaerobic fermentations.


<h2>Very accurate characterization of the fermentation quality</h2>
The Anaerobic Fermentation Monitor from Getinge Applikon is a robust and user-friendly laboratory parallel bioreactor that allows for accurate comparisons of carbon conversion rates and yields for six simultaneous anaerobic fermentations.

It serves not only as the perfect screening machine for general research on anaerobic yeast fermentations, but also as a powerful, time saving tool for plant design and process optimization. A very accurate characterization of the fermentation quality can be obtained, without the need for highly educated laboratory staff, which is an important, money saving feature.

Anaerobic Fermentation Monitor

For cell culture and microbial culture applications.


<h2>Adapt your systems to changed process demands</h2>
The Bio Clave from Getinge Applikon is an autoclavable stainless steel bioreactor which is versatile and easy to use system; offering economical alternatives to steam-in-place bioreactors and fermenters. The Bio Clave range combines the advantages of both, the steam-in place bioreactor (robust design and pressurizable) and the glass autoclavable bioreactors (flexibility and modularity).

Available in 20, 70 and 110 liter volumes. All systems are equipped with a top driven stirrer which can be either a magnetically coupled or a lipsealed stirrer system.

Autoclavable stainless steel bioreactor

pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. New technologies are emerging that warrant accurate measurement and improve durability even in high-temperature steam-sterilization processes.


<h2>Acidity sensor optimized for bioprocesses</h2>
The pH sensor from Getinge Applikon is constructed using FDA approved materials, like the non-toxic solid gel electrolyte. Furthermore this sensor has an internal pressure, which reduces cross contamination. The pH sensor is designed to withstand repeated sterilization cycles without failure.

pH Sensor

Chromatographic monolithic columns for working with large proteins, viruses, VLPs and pDNA require the high structural strength and contamination protection usually provided by expensive medical grade stainless steel.
<h2>Separate complex biomolecules using strong, versatile multi-use columns</h2>
CIMmultus™ disposable monolithic columns from BIA Separations have the structural integrity and leachable profile of medical grade stainless steel, but the process economics of a single or multi-use device.

With the introduction of composite materials into an epoxy-based housing and the application of USP Class VI Parylene C coating to the entire column surface, CIMmultus™ columns offer safety and high performance.

CIMmultus™ columns can be used at any step in the separation process and, with their 2 µm flow-through channels allowing convective mass transfer, make a perfect choice for the purification of viruses, VLPs, plasmids, antibodies, PEGylated proteins and other large biomolecules.

Disposable monolithic columns

Samples taken at various process steps need to be analysed quickly and accurate results delivered, without affecting the state or condition of the original sample.
<h2>Understand a bioprocess through real-time monitoring</h2>
CIMac™ Analytical Columns from BIA Separations are short bed, high performance monolithic columns offering all the advantages of CIM® monolithic technology. They are primarily intended for fast, efficient, and reproducible separations of biomolecules like large proteins, plasmid DNA, and viral particles.

Small volume and short column length allow operation at high volumetric flow rates (from 1 to 30 column volumes/min), enabling product quantity and purity information to be available in just a few minutes.

The CIMac™ Analytical Columns are pre-packed in dedicated stainless steel housings and allow user-friendly connections to HPLC equipment, hence they can be effectively used for both the in-process and final control of various samples from different purification processes.

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Short bed monolithic columns for analytics

When developing a pDNA purification process for eventual transfer into production, efficient examination and selection of protocols is critical.
<h2>Develop plasmid purification procedures quickly</h2>
BIA Separations' CIMmultus™ HiP2 Plasmid Process Pack™ is intended to help scientists easily develop their pDNA purification process and transfer it to production.

Allowing developers to select only the relevant parts of the recommended protocol that best fits their needs, the pack saves time and money on all scales.

The CIMmultus™ HiP2 Plasmid Process Pack™ contains one weak anion-exchange (DEAE) and one hydrophobic (C4 HLD) column and a protocol describing the purification procedure of specific plasmids.

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Plasmid process pack for your pDNA purification process

To purify a specific large biomolecule, for example IgM or a virus or virus-like particle, the first step is to screen the working conditions. Different mobile phases and column chemistries are then tested, according to the biochemical properties of that particular large molecule.
<h2>Efficiently identify, isolate and recover large biomolecules</h2>
The CIMmultus™ Purification Screening Kit from BIA Separations is intended to help scientists quickly discover the optimal stationary phase chemistry for their particular application.

The kit includes two different 1mL CIMmultus™ ion-exchange columns (QA and SO3) and one hydrophobic interaction chemistry column (OH).

By using one of the selected chemistries and applying proper working conditions, the user will be able to discover the combination that will result in appropriate purity and excellent recovery of their required large biomolecule.

Purification screening kit for large biomolecules

<span style="font-weight: 400;">An accurate and sterile sampling of cultures is vital throughout the biopharmaceutical development process. For constant, accurate monitoring, a reliable automated system is needed that transfers bioprocess samples directly from bioreactors to a range of analytical devices without intervention while maintaining the highest levels of sterility. For small-scale development, the availability of a more cost-effective entry-level system brings large economic advantages.</span>
<h2>Affordable automated bioreactor sampling</h2>
<span style="font-weight: 400;">The Seg-Flow 1200 Automated Bioreactor Sampling System from Flownamics is an economical alternative to the larger Seg-Flow 4800. It is available in two models, the Seg-Flow 1200 and the Seg-Flow 1200 Plus.</span>

<span style="font-weight: 400;">Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.</span>

<span style="font-weight: 400;">By incorporating a disposable, single-use flow path, the Seg-Flow 1200 is easy to use and requires little maintenance and no specialist operator training.</span>

<span style="font-weight: 400;">Samples can be collected from up to 2 reactors and delivered to 2 analyzers or collectors. Built-in expansion capability means this can be extended to 4 reactors with the Sample Module.</span>

<span style="font-weight: 400;">Integrated control functions such as an automated feed from an at-line glucose measurement can be quickly and easily implemented.</span>

<span style="font-weight: 400;">The Seg-Flow 1200 can be used with small laboratory vessels right up to large full-scale production vessels with 12, 19, and 25 mm models.</span>

<span style="font-weight: 400;">The unique Flownamics FISP filter probe used in the Seg-Flow 1200 ensures a sterile, cell-free sample can be taken from any vessel.</span>

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Entry-level automated online sampling system

<span style="font-weight: 400;">An accurate, automated sampling of cultures is a key requirement in the development of biopharmaceuticals. For automated sampling across a larger number of bioreactors, a robust and reliable automated system is needed to accurately transfer bioprocess samples directly to a range of analytical devices while maintaining the highest levels of sterility. For medium-scale operations, a cost-effective and efficient system is required to improve process performance.</span>
<h2>Automated multiple bioreactor sampling</h2>
<span style="font-weight: 400;">The Flownamics Seg-Flow 4800 is a fully automated online sampling solution for up to 8 bioreactor vessels. Using unique FISP cell-free sampling probes, the Seg-Flow can deliver accurate samples to up to 4 analyzers.</span>

<span style="font-weight: 400;">Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.</span>

<span style="font-weight: 400;">Rapid and accurate sampling is available for user-defined sample sizes from as little as 250 to 15 ml.</span>

<span style="font-weight: 400;">The internal Flow-Web web server logs data and information for each vessel or stream independently and allows viewing and control from any PC or mobile device.</span>

<span style="font-weight: 400;">The Seg-Flow features a single-use fluid path from the vessel to the analyzer to reduce operating and maintenance costs. The sample line is automatically cleaned or sterilized after each sample. The user-friendly operating system means minimal training is required, and setup is straightforward.</span>

<span style="font-weight: 400;">The Sefg-Flow’s highly flexible operating software can be tailored to your specific applications. It allows data to be saved in spreadsheet format or automatically exported to other software. System status and reporting can be quickly checked from any device with a browser and internet access.</span>

Automatic sampling system for bioprocess monitoring

<span style="font-weight: 400;">Accurate, sterile sample collection is vital across a range of biopharmaceutical, chemical, and industrial processes. To eliminate the risk of contaminating either the culture or the sample, specially designed probes developed to withstand fermentation environments can deliver accurate, cell-free samples for monitoring and development.</span>
<h2>Risk-free sampling for use with bioreactor side ports</h2>
<span style="font-weight: 400;">The Flownamics FISP D-Series is a dedicated sampling probe capable of withdrawing sterile, cell-free samples from fermenters and bioreactors with 25mm side ports from lab scale up to production.</span>

<span style="font-weight: 400;">At the heart of FISP is a fully sterilizable carrier that’s encompassed by a specially designed micro-porous membrane. This has been designed to cope with the most extreme fermentation environments, and it’s ideal for use with anaerobic and aerobic bacterial cultures, yeasts and fungi, and mammal and insect cells.</span>

<span style="font-weight: 400;">With a 0.2 micron filter, FISP’s sterile barrier means zero-risk samples can be taken. Its robust design also means it can easily be used to add media or feeding of cultures. </span><span style="font-weight: 400;">FISP is simple to use and requires no additional operator training. It’s also simple to sterilize and can be used as an autoclave and</span><span style="font-weight: 400;"> manual sampling process. FISP is fully compatible with the Seg-Flow range - Flownamics’ automated sampling products.</span>

Sampling probe suitable for fermenter samples

<span style="font-weight: 400;">Advanced biopharmaceutical and lab systems involving microcarrier and stem cell applications require daily media changes. This carries the risk of contamination and of cells leaving the reactor or detaching from their microcarriers. A dedicated and flexible system to achieve complete filtration will improve the efficiency and eliminate the risks in perfusion operations at any scale.</span>
<h2>Highly flexible small-scale perfusion controller</h2>
<span style="font-weight: 400;">The PMR system from Flownamics utilizes FISP probe technology for aseptic media removal from any size of bioreactor. With PMR, cells never leave the reactor.</span>

<span style="font-weight: 400;">FISP probes in combination with a patented dual fluid sensor pump control offer the ideal in-situ </span><span style="font-weight: 400;">perfusion system for small scale reactors at a low cost.</span>

<span style="font-weight: 400;">PMR only requires 100ml of total working volume in the reactor thanks to the minimal dead volume in the FISP probe. This is ideal for smaller scale or lab work because other perfusion systems typically require a much larger volume to operate.</span>

<span style="font-weight: 400;">The PMR system is perfect for advanced processes involving microcarrier and stem cell applications that require frequent media exchanges, providing an in-situ filtration solution that keeps cells in the reactor and attached to their microcarriers.</span>

<span style="font-weight: 400;">A web-based user interface provides complete control over flow rates (independent control over addition and removal pumps) from 0.1ml/min to 50 ml/min.</span>

Perfusion process controller

An autoclavable bioreactor establishes special conditions for a variety of applications, for example yeast and microbial cultivation. These conditions may include particular high and low pressures, and temperatures without which a particular chemical reaction or biological event cannot occur.


<h2>A Bundled Reactor for Yeast, Microbial and Mammalian Cell Cultivations</h2>
An EZ2 control bundle from Getinge Applikon is a complete bioreactor system containing everything needed to facilitate bioprocesses. The equipment is easy to set up, does not require special tools or skills, and is easy to learn to operate. Software for data acquisition is included.

Typical projects could include yeast and microbial culture, and also mammalian cultivation including suspension and anchorage-dependent cells. Continuous perfusion cultures are also a possibility, because everything down to silicon tubing, sample bottles and even spare parts are in the kit.

Getinge Applikon touched on all the details when designing its EZ2 system. The quiet agitation motor will hardly be noticed in a busy laboratory, while the sophisticated controller is simple to use thanks to an integrated touch screen. A USB port enables software updates without needing a service engineer.

The EZ2 bundled reactor range includes 2, 3, 5, 7, 15, and 20 litre total volume sizes for cell or microbial cultures.

Complete bioreactor system

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