Assembles and Labels Medical Syringes

The COMBI 3 BS, COMBI 3 BSR, and COMBI 1 BS from Marchesini Group are high-speed continuous motion machines designed for the precise assembling and labeling of syringes, critical for pharmaceutical and biotech applications. These machines address the challenge of efficient syringe preparation, including plungering, labeling, and backstop assembly, for an array of end-products such as insulin, oncological, and vaccine syringes.

Operating with the ability to handle glass or plastic syringes, these solutions achieve an output rate of up to 24,000 syringes per hour, ensuring a seamless integration into high-demand production lines. The automation features include PLC control paired with an automatic syringe loading system, elevating operational reliability and repeatability. Designed with minimal installation footprints, they employ positive logic for component management, reducing downtime and ensuring accuracy.

Customization options abound, with components such as vision systems and feeding systems available, making this machinery adaptable to specific operational needs. They comply with GMP standards, supporting pharmaceutical-grade production environments. Easy maintenance is facilitated with features like automatic rejection systems for non-compliant products and contactless counting systems, offering ease of upkeep and operational continuity.

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Processes and Stoppers Vials for Liquid Formulations

The vial filling and stoppering machine from groninger offers a cutting-edge solution for pharmaceutical and biopharmaceutical production lines. This equipment encompasses an integrated process for washing, sterilizing, filling, and stoppering vials, ensuring seamless operations from start to finish. Designed for a diverse range of liquid formulations, including vaccines, insulin, and monoclonal antibodies, it supports production outputs between 50 and 600 units per minute, accommodating both small and large batch operations.

Engineered for sterile areas and clean rooms, the machine adheres to cGMP requirements, integrating easily into your existing production line. The system features a quickconnect format changeover for minimal downtime, allowing tool-free transitions between different vial formats. Groninger’s vial filling machine is designed with 100% In-Process-Control (IPC) to maximize precision, coupled with smartfill technology to minimize product loss and achieve optimal efficiency.

This automated line can incorporate additional processes like freeze drying and external vial cleaning, enabling aseptic processing even to OEB5 or BSL2 levels. The equipment incorporates advanced technology like PUPSIT, CIP/SIP options, and a single-use fill path to avoid cross-contamination. It further offers flexibility in sealing with various rubber stoppers and push-fit closure systems like RayDyLyo®.

Constructed for durability and reliability, the machine can be tailored with materials like stainless steel to meet specific corrosion resistance needs. With compliance to EU GMP standards, the groninger vial filling and stoppering machine stands as a robust and adaptable choice for high-speed, automated pharmaceutical production.

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Fills and Closes RTU Vials, Cartridges, and Syringes

The flexpro 50 from groninger is an advanced aseptic filling machine tailored for the pharmaceutical and biotech sectors, excelling in filling and closing ready-to-use (RTU) vials, cartridges, and syringes. This system features the smartfill technology, incorporating 100% In-Process-Control (IPC) to minimize product loss and ensure precision during start-up and production. Ideal for applications in biopharmaceuticals, personalized medicines, and injectable therapies, it accommodates end-products like monoclonal antibodies, mRNA vaccines, and oncology drugs. Supporting high-speed, continuous operations, it seamlessly integrates into automated production lines and offers flexible format changeovers without tools, thanks to the quickconnect feature. Constructed for compliance with GMP standards, it assures sterile conditions via safetransfer methods, safeguarding the sterile introduction of components into the aseptic area. With scalable output and engineered customization, the flexpro 50 suits diverse production scales, from R&D labs to full-scale manufacturing.

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Assembles and Inspects Pharmaceutical Syringes and Containers

Groninger’s Syringe Assembly Machines offer an integrated solution for the precise assembly and inspection of pharmaceutical primary packaging, including syringes, vials, and cartridges. These machines excel in handling delicate processes such as plunger rod insertion, labeling, and safety device assembly, ensuring the integrity of prefilled syringes used for a range of medical applications, from insulin delivery to vaccination. Capable of processing up to 600 objects per minute, these machines boast a modular design that allows for easy line integration and expansion with features like backstop mounting and advanced inspection systems. Their electromotive mechanisms ensure minimal energy consumption while maintaining high precision assembly. Stainless steel construction provides durability and compliance with GMP and FDA standards. Cleaning is simplified with an integrated tray loading and buffering system, complemented by comprehensive engineering support for customization to meet specific production requirements.

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Fills and Assembles Aseptic RTU Containers

The flexfill from groninger is an advanced filling machine designed for precise handling of aseptic pharmaceutical products in ready-to-use (RTU) containers. It specializes in filling and closing pre-sterilized syringes, vials, and cartridges, making it ideal for pharmaceuticals such as pre-filled syringes and vial-based vaccines. Employing no-touch transfer (NTT) and E-Beam decontamination options, it ensures contamination-free transfer into aseptic environments. Handling capacities range from small pilot batches to high-speed industrial production, accommodating up to 1,000 containers per minute, all controlled via a PLC system for seamless integration into production lines. Meeting strict GMP compliance, flexfill optimizes throughput with features like smartfill technology for minimal product loss and robust energy efficiency. Stainless steel construction ensures chemical compatibility, and automated in-process control (IPC) assures precise filling accuracy, making it a reliable choice for complex biopharmaceutical manufacturing needs.

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Automates Aseptic Filling and Closing

The Robocell from groninger is a state-of-the-art gloveless robotic system designed for aseptic filling and closing of ready-to-use (RTU) syringes, vials, and cartridges. What sets the robocell apart is its complete automation, eliminating human intervention and thereby enhancing contamination control. It operates through an integrated robotic technology system, making it suitable for filling complex products like biological drugs, ADCs, and ATMPs across small and medium batches. The system boasts high flexibility, capable of handling various packaging materials—from pre-sterilized to snap-on caps—while achieving reduced changeover times with minimal format parts. Compliance with EU GMP Annex 1 ensures it meets stringent pharmaceutical standards, while an incorporated PUPSIT facilitates integrity testing, even in the absence of glove ports. With capabilities for CIP, robust cleaning, and maintenance, the robocell integrates seamlessly into processing and packaging operations, supporting pharmaceutical and biotech industries with reliable, hygienic aseptic production solutions.

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Fills and Caps Liquid Products in Small Batches

The Flexcare 10 from Groninger is a versatile filling and capping machine tailored for consumer healthcare, pharmaceutical, diagnostic, and dietary supplement manufacturers. This compact system excels in processing small batches of liquid products like cough syrups, eye drop solutions, and vitamin supplements. With capabilities including pre- and post-gassing, filling, and screwing, the Flexcare 10 ensures precise weight control and reliable sealing of glass and plastic bottles. It supports a range of filling systems, accommodating rotary piston pumps or peristaltic pumps based on product needs. Operating at speeds up to 70 containers per minute, it handles volumes from 1 to 400 ml, while its tool-free format changeover minimizes downtime. The machine’s GMP-compliant design integrates seamlessly into production lines, offering laminar flow attachment for contaminant-free filling. Furthermore, the Flexcare 10 provides customization options to meet specific process requirements, backed by Groninger’s engineering support for optimal production efficiency.

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Fills, Seals, and Monitors Liquid Products

The flexcare 100 from Groninger is a high-efficiency liquid filling machine designed to meet the versatile demands of consumer healthcare and pharmaceutical industries. Its standout feature is the tool-free change of format parts, enabling seamless processing of various liquids like eye drops, cough syrups, and nasal sprays. The machine supports continuous, high-speed operations, capable of achieving outputs up to 120 units per minute, depending on the filling volume and closure type. With integrated 100% weight monitoring, it ensures precise and reliable filling, reducing product loss and minimizing manual oversight. The flexcare 100 employs hygienic design principles, facilitating easy cleaning and maintenance and aligning with GMP compliance. Employing servo technology, it provides accurate filling and sealing using multiple systems, including volumetric rotary piston pumps and peristaltic pumps. Its multi-functional closing units accommodate diverse closure types, making it a robust choice for dynamic production environments. Customization and engineering support ensure the flexcare 100 can be tailored to specific production requirements, guaranteeing its fit across manufacturing setups.

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Labels and Assembles Disposable Syringes

The SME Series from Bausch+Ströbel offers precision-engineered machines for the efficient labeling and assembly of disposable syringes. This compact, continuous-motion system features a modular design, allowing you to adapt and expand your setup as production demands evolve. Equipped with a basic module for applying self-adhesive labels and inserting plunger rods without pressure, the SME Series ensures reliable and high-quality construction of glass or plastic syringes. Designed for applications in pharmaceuticals and medical devices, this series handles a range of syringe types, including safety and prefilled syringes, at impressive speeds of up to 36,000 items per hour. A centralized operation system and short setup time enhance efficiency and ease of use, while options like vision systems and various label printers ensure process reliability and quality control. Fully customizable with extensions and extras for safety enhancements, this solution integrates seamlessly into your existing line, supporting efficient upstream and downstream connectivity. The SME Series complies with industry standards, offering sophisticated inspection, rejection, and maintenance features tailored to meet stringent pharmaceutical requirements.

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Assembles, Labels, and Validates Syringes

The Type 607 from BAUSCH Advanced Technology Group is a versatile machine for high-speed syringe assembly and labeling, tailored to meet the demands of pharmaceutical and biotech industries. Featuring servo-controlled drives, it provides precise torque monitoring during plunger rod insertion and backstop assembly. Suitable for a broad range of syringe types and sizes, it integrates seamlessly into your production line, or can function independently, processing up to 24,000 syringes per hour. Its built-in vision system ensures label accuracy, automatically rejecting non-conforming containers. With options for hot foil, ink jet, or laser printing, the Type 607 supports adaptable labeling processes. This machine complies with industry standards, ensuring reliability and efficiency in producing prefilled syringes for insulin, vaccines, and biologics. Its compact design facilitates easy integration, while offering customization options and comprehensive engineering support for specific production needs.

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