Cultivates and Ferments Cells for Food Production

The Axenic® C Bioreactor from GEA is an industrial-scale system specifically designed for cultivating mammalian and eukaryotic cells in the food industry, focusing on applications like cultivated meats and precision fermentation. Utilizing a stirred tank reactor approach, it allows both fed-batch and continuous cultivation processes, making it suitable for producing cultured chicken breast and plant-based protein patties. The system integrates GEA’s Virtual Bioreactor Testing technology, which employs digital twin simulations to optimize shear forces, oxygen transfer rates, and temperature settings tailored to your specific cell cultures.

Importantly, the Axenic® C is fully automated, featuring the GEA Codex® process control platform for enhanced operational stability and reduced manual intervention, minimizing contamination and maximizing process repeatability. It offers multiple gas connections and perfusion capabilities to manage gas dissolution and remove inhibitory by-products, ensuring consistent cell growth and high yield production. Compliance with food industry regulations makes it ideal for innovators in cultivated fats and new food sectors. The system supports CIP for effective cleaning, and its modular design can be customized with expert engineering support to fit seamlessly into both upstream and downstream processes, enhancing your production line’s efficiency and sustainability.

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Cultivates and Ferments Microbial Cells at Scale

The GEA Axenic® M bioreactor system, designed for microbial and precision fermentation, offers a specialized solution tailored for the burgeoning needs of the food industry, particularly in the areas of alternative proteins and new food products. This industrial-scale system employs a stirred tank reactor approach to enable both fed-batch and continuous cultivation, allowing for efficient growth of engineered cells. What sets the Axenic® M apart is its focus on regulatory compliance and adaptability to the distinctive requirements of microbial processes, addressing specific needs such as oxygen transfer and temperature control using its Virtual Bioreactor Testing technology. This advanced digital twin simulation tool allows for precise optimization of the system, ensuring energy-efficient operation and optimal yield.

Capable of handling industrial-scale operations, the Axenic® M is fully automated, utilizing GEA’s Codex® process control platform for process stability and safety, reducing manual intervention and potential for error. Designed to integrate seamlessly into existing production lines, this system supports continuous and pilot-scale operations, catering to food industry manufacturers and fermentation technology developers. With options for external cooling loops, it maintains temperature consistency and mitigates cleaning risks, ensuring a high level of production repeatability. The Axenic® M also supports comprehensive customization, providing consultation and engineering support to fine-tune the system to specific production needs.

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Scales Up Cell Cultivation and Fermentation Processes

The GEA Axenic® P from GEA Group is a pilot-scale bioreactor designed to facilitate the transition from laboratory to industrial-scale cell cultivation and fermentation. This versatile bioreactor is equipped with comprehensive data collection and process optimization features, enabling exact control over conditions vital for producing cultivated meat, precision-engineered dairy products, and fungal mycelium. By emulating conditions similar to industrial environments, it allows for seamless upscaling and testing of new food processes.

With a flexible, fully reusable design, the Axenic® P supports a variety of cell types and configurations, incorporating multiple inlets for media and gas delivery. It is semi-automated for integration into existing setups or to function as a standalone unit. Using a virtual modeling system, it predicts cell behavior during scale-up, ensuring process stability and yield. The system emphasizes sustainability and efficiency, utilizing split range control for oxygen delivery and integrating CIP solutions for minimal maintenance downtime. Suitable for diverse industries such as food and pharma, the Axenic® P meets the evolving demands of R&D in alternative protein and new food production.

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Scales and Optimizes Cell Culture Processes

The PBS-15 Vertical-Wheel Bioreactor from PBS Biotech is designed to advance your cell culture processes by integrating the unique vertical-wheel design for superior mixing and scalability. This bioreactor supports applications in biopharmaceuticals, cell therapy, and regenerative medicine, producing high-quality end products like CAR-T cell therapy and microcarrier-based stem cell cultures. With a maximum working volume of 15 liters, it efficiently scales up from bench-top experiments to clinical production. Equipped with a touchscreen interface, it offers intuitive process control and customization, allowing for seamless medium exchange and sampling via an adjustable height harvest valve. It supports both single-use and reusable sensor configurations, ensuring operational flexibility. The PBS-15’s software allows for remote monitoring and data storage in compliance with 21 CFR Part 11 standards. Designed for easy cleaning and maintenance, it is ideal for pharmaceutical manufacturers, cell therapy developers, and research laboratories looking to optimize their cell culture workflows.

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Cultures and Scales Therapeutic Cells

The PBS-3 Vertical-Wheel Bioreactor from PBS Biotech is designed to optimize your cell therapy production processes. This single-use, stirred suspension bioreactor offers customizable process parameters, effectively addressing complex needs in therapeutic cell cultivation, such as mixing, monitoring, and sampling. It caters to applications including MSC, hiPSC, CAR-T, and NK cell therapies, and is suitable for biotech and pharmaceutical industries. The bioreactor is engineered to simplify the scale-up process from laboratory to clinical trials, ensuring smooth transition to larger volumes. Featuring real-time data monitoring and process control, it allows remote access for adjustments and alarms via a secure interface. The system supports the integration of single-use or reusable sensors for DO and pH, meeting FDA and GMP standards. Available as a compact, bench-top system, it fits effortlessly into research and development environments, making it a versatile addition to your cell therapy production line.

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Cultivates and Expands Therapeutic Cells at Scale

The PBS-80 Vertical-Wheel Bioreactor from PBS Biotech is engineered for large-scale manufacturing of therapeutic cells. It uses a unique vertical-wheel design that optimizes hydrodynamic conditions for anchorage-dependent human cells, such as cell aggregates and cells grown on microcarriers. With an 80-liter working volume, it meets the demands of both clinical stage production and commercial scale manufacturing. This bioreactor integrates seamlessly into your processing line, featuring an adjustable height harvest valve for efficient medium exchange and harvesting. Equipped with a touchscreen interface, it allows for intuitive customization and real-time process monitoring, including remote control capabilities. The PBS-80 supports advanced automation and ensures compliance with 21 CFR Part 11 cGMP standards. Available with single-use or reusable sensors, it offers flexibility in operation while being easy to clean and maintain. With PBS Biotech’s engineering support, you can tailor this bioreactor to meet specific production needs, making it ideal for producing CAR-T cell therapies, NK cell therapies, and other stem cell products.

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Mixes and Emulsifies Shear-Sensitive Biopharmaceuticals

The Truelev Mixer from Metenova offers a revolutionary solution for shear-sensitive biopharmaceutical applications. Utilizing fully levitating, bearing-less technology, the Truelev Mixer provides gentle mixing without mechanical friction, tailored for sensitive tasks such as proteins and enzyme solutions. This mixer is ideal for producing high-value biopharmaceutical products, including monoclonal antibodies and vaccine formulations. It integrates seamlessly into both batch and continuous operations within pharmaceutical and biotech industries.

Engineered with electromagnetic bearings, the Truelev Mixer eliminates wear parts, achieving maintenance-free operation and reducing risk of contamination or product compromise. It collects real-time performance data for superior process control and analytics. Available configurations include the Truelev Mobile, designed for mobile vessels required between multiple facilities. This system is constructed from high-grade materials ensuring chemical compatibility, and it adheres to GMP and FDA standards, providing assurance in regulatory compliance for pharmaceutical manufacturing.

Configurability includes optional Mix Heads for diverse process needs, and comprehensive customization support is offered to adapt to specific production requirements. This sophisticated mixer ensures efficient, contamination-free cleaning, thanks to its integrated cleaning capabilities, aligning with strict industry hygiene standards.

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Controls and Optimizes Bioreactor Operations

The Single Use Bioreactor Control System offered by Marubishi Bioengineering is a customizable solution designed to seamlessly integrate into your biopharmaceutical production line, particularly when managing complex cell cultures and monoclonal antibody production. Its standout feature is the ability to tailor the control system according to your specific bioprocessing strategies, ensuring optimal performance and compliance with unique operational requirements.

This system excels in managing single-use bioreactors, commonly used in generating recombinant proteins and viral vectors intended for gene therapy. It supports continuous operations with an integrated SIP (Sterilization-In-Place) and CIP (Clean-In-Place) functionality to maintain sterility and operational efficiency.

Built for versatility, the system can manage various processing capacities, integrating smoothly with existing upstream and downstream processes. With a focus on energy efficiency, it incorporates advanced software for precise environment control, reducing energy consumption and system downtime.

Engineered from high-grade materials suitable for stringent biopharmaceutical conditions, it stands robust against potential corrosion, ensuring longevity and reliability. Certified to adhere to cGMP and FDA standards, this system is designed for the highest levels of compliance in the bioprocessing and life sciences industries.

For enhanced usability, it includes comprehensive support for system customization, remote monitoring, and flexible operational adjustments, ensuring it meets the varied demands of biotech and pharmaceutical applications.

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Cultivates and Optimizes Microbial and Cell Cultures

The Desk Top Fermentor from Marubishi Bioengineering offers a versatile solution for biotech and pharmaceutical applications, accommodating various cell types from microbes to mammalian cells. Its unique hollowed bottom end plate facilitates accurate temperature control through mild heating and rapid cooling, ensuring optimal fermentation conditions. With interchangeable vessel sizes up to 10 liters, it provides full-scale fermentation capabilities in a compact form. Tailored for precision, it includes top or bottom entry driving systems and multiple stirring impellers to cater to different culture processes, such as aerobic and anaerobic fermentations. Ideal for producing biologics, vaccines, and enzyme supplements, this fermentor features a user-friendly interface, integration with bioprocess controllers, and options for data logging via USB. The equipment is energy-efficient, utilizing mass flow controllers for aeration and precise agitation systems. Available in materials that resist corrosion, it is suitable for harsh processing environments. The fermentor conforms to industry standards for quality and safety, offering seamless integration into existing production lines and easing operational challenges through its modular design and easy maintenance. Customizable features include pressure handling up to 0.2MPa(G) and optional automation enhancements, ensuring optimal performance across diverse fermentation applications.

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Facilitates Bioculture Sterilization and Harvesting

The MSJ and MPF Series from Marubishi Bioengineering are engineered-to-order fermentors tailored for diverse bioprocessing needs in the biotechnology and pharmaceutical industries. These fermentors are distinguished by their ability to perform sterilization in place using live steam, ensuring contamination-free operations for producing high-quality bioproducts such as monoclonal antibodies, recombinant proteins, and biofuels.

Available in sizes ranging from 10 to over 10,000 liters, these systems cater to both research and industrial-scale operations. They feature graphic touch panels and automated control systems, allowing seamless integration and streamlined operations including sterilization, sampling, and precise agitation. The fermentors accommodate various culture types—microbial, mammalian, and recombinant DNA—backed by Marubishi’s extensive experience.

Built with mechanical seal technology, these fermentors optimize energy usage and sterility. Offered with options for pH, DO, and airflow monitoring, they support a wide array of applications from R&D labs to large-scale production facilities. Marubishi provides comprehensive engineering support for custom configurations, ensuring compatibility with GMP standards and ease of maintenance with flexible cleaning systems.

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