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Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Success with bioprocesses is all about controlling the environmental conditions controls so you can replicate processes consistently. Good insight and easy adjustment of pH, Temperature, Dissolved Oxygen, Foam/Level and Agitation are crucial for any biopharmaceutical process.


<h2>Easy to use control for lab scale operation</h2>
The ez2-Control from Getinge Applikon is an easy to use control and measurement system for bioreactors and fermentors. The bioreactor control system offers high accuracy, a good insight and easy adjustment of pH, Temperature, dissolved Oxygen, Foam/Level and Agitation, which are crucial for any biopharmaceutical process.

The colour touch screen interface guides the user through the operation.  The adaptive control features allow the user to focus on the process while the controller keeps tight control on the important process parameters.

The new web-interface for ez2-Control with advanced user management option provides a clear overview of the bioprocess parameters. Also it allows back-ups, copies and predefined settings of configurations to be simply shared via USB.

The ez2-Control can be used to control a large variety of reaction environments: From autoclavable bioreactors, steam in place bioreactors, to Appliflex single use bioreactors, milipore Cell Ready single use bioreactors or HyClone SUB bioreactors.

Lab scale Bioreactor controller

Innovators in the highly regulated and highly dynamic pharmaceutical market place need equipment that is worry-free and flexible enough to vary products and process variables as new products are developed.  Laboratory capsule filling machine must be easy to maintain, allow for rapid tooling change-over, and provide tightly controlled process variables and automatic operation in order to ensure results that are reproducible at the production scale.


<h2>A complete encapsulation solution for the laboratory</h2>
The AFT-T Lab system from ACGE is a laboratory capsule filler from the AF series of capsule fillers that is currently running in over 1000 production facilities throughout the world.  The AF series of machines is built for regulatory compliance, revenue optimization, and flexibility giving pharmaceutical manufacturers the features they demand such as formulation and dosing control, minimal product loss, a wide range of peripheral equipment, and globally available support.

The AFT-T Lab machine has all the benefits associated with the larger equipment in the series but on a scale appropriate for laboratories.  The machine can output up to 6,000 capsules per hour for powder filling and 5,000 capsules per hour for pellet filling.  It uses a 1.1 kW primary motor.  It weighs about 1,200 Kg and occupies only 2.25 square meters of floor space making it the perfect scale for any pharmaceutical laboratory.

Automatic laboratory capsule filler

Use of liquid filled hard capsules is increasingly popular with today's pharmaceutical manufacturers.  Bioavailability and patient compliance are enhanced with drugs delivered in this form.  Production of these liquid filled capsules requires equipment that can handle a wide variety of liquids including lipids and waxes, and automatically produce consistent sealed capsules as well as efficiency and high machine up-time to ensure profitability.


<h2>Automatically fill and seal hard capsules with any pharmaceutical liquid</h2>
Fluidocap F40 is a fully automatic machine for filling hard pharmaceutical capsules with liquid an sealing them.  It is provided by ACGE-Associated Capsules a world leader in pharmaceutical machinery manufacturing. Traditionally liquid doses have been provided in soft gel-cap form and have presented drug makers with the common problems of high cost, wastage, cross contamination, migration of the drug into the capsule, and low bioavailability.

The Fluidocap range of machines address these issues by allowing the filling and sealing of hard capsules with liquid compounds rather that relying on soft gelcaps.  The hard capsules can be filled with a wide range of formulations including lipid-based products, high viscosity pastes, and wax type products. They are sealed with a gelatin band. The capsule filler for liquid is designed for high volume production use and can produce up to 40,000 capsules per hour. Combinations filling including pellets in liquid is also possible using special attachments.

Automatic capsule filler for liquid solutions

Preparation lines for formulating pharmaceuticals include fixed and mobile tanks for liquid solutions. These vessels must withstand high internal pressures while enabling fast production. Their design must meet aseptic standards for manufacture of pharmaceuticals, and comply with good manufacturing practice.
<h2>Preparation Tanks for Pharmaceutical Formulation</h2>
BRAM-COR manufactures a range of dissolutor tanks. All vessels are made of AISI 316L stainless steel, and comply strictly with PED standards and ASME "U" stamp certification.

Formulation tanks are an indispensable part of all pharmaceutical preparation processes. BRAM-COR DISS fixed or mobile tanks are suitable for low, medium, or high density liquid solutions. This includes parental solutions and also ointments and creams.

Every tank has at least one mixer / agitator, a spray ball for cleaning-in-place, and an optional load cell for maintaining safety, precision and performance. Various levels of automation are available for controlling raw material input. External heating jackets are provided where required.

Tanks capacities range from 50 to 25,000 litres. Staircases and safety platforms provide access to large installations for inspections.

Pharmaceutical formulation and mixing tanks

Find production technology for Probiotics formulation, and connect directly with leading machine manufacturers worldwide

Probiotics formulation

Which probiotics formulation equipment do you need?

Lab scale Bioreactor controller

Automatic laboratory capsule filler

Automatic capsule filler for liquid solutions

Pharmaceutical formulation and mixing tanks

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