Vertical centrifuge for plasma fractionation

Achieve high-purity plasma derivatives with precision; this vertical centrifuge ensures optimal yield and gentle treatment during plasma fractionation, vital for high-standard biopharmaceutical production.

Separates and Purifies Plasma Fractions Efficiently

The Series V 630 TS and V 800 TS from HEINKEL Drying and Separation Group are vertical centrifuges designed specifically for pharmaceutical applications, particularly in the separation of plasma fractions. These centrifuges effectively optimize the yield and purity of critical components such as albumin and immunoglobulins, thanks to their sophisticated design and operation. Utilizing a high-speed centrifugal force, they ensure efficient separation while maintaining the integrity of sensitive biological products.

These models are engineered to process multiple plasma derivatives, including clotting factors and immunoglobulins, commonly used in biopharmaceutical and fine chemical industries. With a processing framework that includes cooling, filling, centrifuging, discharging, and cleaning, they deliver a seamless integration into existing production lines. The double-walled housing ensures constant product temperatures, meeting GMP’s highest requirements and facilitating an environment for sterile operation.

The centrifuges feature a permanent direct drive system, enhancing performance dynamics with low space requirements due to their compact design. Moreover, automation is achieved through PLC-controlled operations which offer remote monitoring. The stainless steel construction supports excellent corrosion resistance, ensuring longevity and compatibility with various process environments. Cleaning is expedited via a CIP system, guaranteeing swift and contamination-free maintenance between batches. Designed with pharmaceutical manufacturers in mind, the Series V 630 TS and V 800 TS offer customizable throughput and rotor speeds to accommodate specific production needs.

Benefits

  • Achieves high-purity plasma fractionation, enhancing product quality and yield.
  • Reduces operational space with compact design, optimizing plant floor layout.
  • Ensures sterile processing and compliance with GMP standards for safety and reliability.
  • Minimizes contamination risk with efficient CIP cleaning system.
  • Improves process efficiency with constant temperature control, maintaining product integrity.

General


Applications
Biopharmaceuticals,Fine chemicals,Plasma fractions,Pharmaceuticals
End products
Plasminogen,Coagulation factor viii,Intravenous immunoglobulins (ivig),Immunoglobulins (igg),Antithrombin iii,Coagulation factor ix,High-purity plasma derivatives,Albumin,Alpha-1 antitrypsin,Clotting factors,Human serum albumin
Steps before
Cooling,Filling
Steps after
Discharge of product,Cleaning
Input ingredients
blood plasma
Output ingredients
plasma fractions,valuable raw material,medicine substances
Market info
Heinkel is known for manufacturing high-quality industrial equipment, specializing in centrifuges, dryers, and other engineered-to-order machinery for the chemical, pharmaceutical, and environmental sectors, with a reputation for innovation and reliability.

Technical Specifications


Basket diameter
630 mm / 800 mm
Basket depth
315 mm / 420 mm
Filter area
0.625 m² / 1.06 m²
Nominal volume
250 L / 600 L
Max. Filling
62 kg / 125 kg
Max. Speed
3,000 1/min
Centrifugal force
3,170 x g / 2,590 x g
Temperature control
Constant product temperature
Sterile design
Includes feed and suction pipe
CIP cleaning
Meets GMPC requirements
Direct drive
Permanent for higher dynamics and performance
Compact design
Low space requirement
Cooling
Included as part of the process

Operating Characteristics


Working Mechanism
Plasma Fractionation
Integrated Steps
Cooling,Filling,Centrifugation,Discharge,Cleaning
CIP Principles
Sterile machine design according to GMP
Batch vs. Continuous Operation
Batch
Automation Level
Permanent direct drive
Cleaning Method
CIP
Space Requirement
Compact Design
Temperature Control
Double-walled Centrifuge Housing

Material Compatibility


Biological compatibility
Yes
Cleanability
CIP compliant
Corrosive resistance (e.g. acids)
Yes
Abrasion resistance
Yes
Density/particle size
0.5–2.5 g/cm³ / Customizable size

Physical Characteristics


Machine footprint
Compact design
Basket diameter
630 mm / 800 mm
Basket depth
315 mm / 420 mm
Nominal volume
50 L / 100 L
Max. Filling
62 kg / 125 kg
Discharge method
Top discharge
Control panel type
Permanent direct drive
Centrifugal force
3,170 x g / 3,000 x g
Dimensions
Length
Width
1,100 mm - 1,300 mm
Height
1,680 mm - 2,060 mm
Weight
2,200 kg / 3,200 kg
Sterile machine design
Includes feed pipe and suction pipe
CIP cleaning
Meets GMP requirements
Clean room solution
Yes

Custom Options


Control panel type
HMI / PLC
Cooling system
Double-walled centrifuge housing
Compact footprint
Low space requirement
Sterile design
Sterile feed pipe and suction pipe
CIP cleaning
Meets GMPC requirements