Cultures and Scales Therapeutic Cells

The PBS-3 Vertical-Wheel Bioreactor from PBS Biotech is designed to optimize your cell therapy production processes. This single-use, stirred suspension bioreactor offers customizable process parameters, effectively addressing complex needs in therapeutic cell cultivation, such as mixing, monitoring, and sampling. It caters to applications including MSC, hiPSC, CAR-T, and NK cell therapies, and is suitable for biotech and pharmaceutical industries. The bioreactor is engineered to simplify the scale-up process from laboratory to clinical trials, ensuring smooth transition to larger volumes. Featuring real-time data monitoring and process control, it allows remote access for adjustments and alarms via a secure interface. The system supports the integration of single-use or reusable sensors for DO and pH, meeting FDA and GMP standards. Available as a compact, bench-top system, it fits effortlessly into research and development environments, making it a versatile addition to your cell therapy production line.

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Cultures and Expands Stem Cells and MSCs

The PBS-Mini Vertical-Wheel Bioreactor from PBS Biotech is a cutting-edge solution designed for precise and scalable cell culture processes. Its unique Vertical-Wheel technology facilitates gentle yet effective mixing, optimizing conditions for stem cell culture and T cell expansion. Ideal for biopharmaceutical and cell therapy applications, this bioreactor accommodates single-use vessels with working volumes of 0.1L or 0.5L, providing flexibility for various research and development needs. The system’s compatibility with incubators allows for controlled temperature and gas conditions, essential for reproducible results. Constructed with materials that meet regulatory standards, it ensures compliance for first-in-human clinical trials. The PBS-Mini is engineered for seamless integration into laboratory and pilot-scale operations, featuring removable caps for sterile sampling and harvesting, and is supported by comprehensive user resources and customization options.

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Scales and Optimizes Cell Culture Processes

The PBS-15 Vertical-Wheel Bioreactor from PBS Biotech is designed to advance your cell culture processes by integrating the unique vertical-wheel design for superior mixing and scalability. This bioreactor supports applications in biopharmaceuticals, cell therapy, and regenerative medicine, producing high-quality end products like CAR-T cell therapy and microcarrier-based stem cell cultures. With a maximum working volume of 15 liters, it efficiently scales up from bench-top experiments to clinical production. Equipped with a touchscreen interface, it offers intuitive process control and customization, allowing for seamless medium exchange and sampling via an adjustable height harvest valve. It supports both single-use and reusable sensor configurations, ensuring operational flexibility. The PBS-15’s software allows for remote monitoring and data storage in compliance with 21 CFR Part 11 standards. Designed for easy cleaning and maintenance, it is ideal for pharmaceutical manufacturers, cell therapy developers, and research laboratories looking to optimize their cell culture workflows.

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Controls and Monitors Bioreactor Cultivation Processes

The Livit Flex from Getinge is a configurable bioprocess controller designed for seamless integration into bioreactor systems. It simplifies the management of complex cell and microbial culture processes, supporting applications in pharmaceuticals and biotech. With capabilities for single or dual bioreactor control, it accommodates both single-use and multi-use setups, maximizing bench space efficiency. The incorporated intuitive Livit software platform allows for comprehensive data logging and process monitoring, enabling you to manage bioprocesses with precision. Supports a variety of operations including batch, fed-batch, perfusion, and continuous cultivation for end-products like monoclonal antibodies and vaccines. Its plug-and-play compatibility with a range of sensors and auxiliary devices enhances workflow efficiency, while ensuring adherence to GMP standards. The Livit Flex promises reliable performance, reduced operator error, and flexibility in meeting your unique R&D needs.

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Facilitates Scalable Single-Use Bioprocessing

The SUPR from Getinge Applikon is a single-use production reactor designed for bioprocessing applications in the biopharmaceutical industry. Leveraging the Click-n-Go system for rapid setup, it simplifies cultivation and sampling, ideal for monoclonal antibody production, CAR-T cell therapies, and mRNA vaccines. It supports seamless scaling from R&D to production, utilizing 50 to 250-liter containers, with a 1000-liter option forthcoming. Constructed from USP Class VI certified materials, it eliminates cross-contamination and minimizes cleaning requirements through gamma irradiation. The SUPR integrates easily with existing systems, offering compatibility with DeltaV™ DCS and Siemens PLCs. It complies with cGMP standards, ensuring quality and regulatory alignment for biotechnological applications.

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Cultivates and Scales-Up Cell Cultures

The Applikon AppliFlex ST from Getinge offers a versatile single-use stirred tank bioreactor designed for biopharmaceutical applications. This bioreactor stands out with its fully customizable design, incorporating 3D printing technology for tailored head plate configurations. It excels in cell line development and process scale-up for producing monoclonal antibodies, CAR-T cell therapies, and other biologics. Capable of cultivation, mixing, and fermentation processes, it offers working volumes of 500 mL to 15 L. With the use of single-use technology, it ensures sterility and minimizes contamination risk, effectively supporting batch, fed-batch, and perfusion operations. The bioreactor is constructed for easy integration into lab environments and complies with industry standards, promoting efficient, reproducible results in research and development settings.

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Facilitates Cell Cultivation and Fermentation Processes

The BioFlo® 320 Bioreactor from Eppendorf is an engineered-to-order solution designed for complex bioprocessing needs. Featuring both glass and single-use vessel options with interchangeable magnetic and direct drive mechanisms, it supports cell cultivation and fermentation in R&D and industrial settings alike. Ideal for producing monoclonal antibodies, biofuels, and biopolymers, it accommodates batch, fed-batch, and continuous operations with working volumes ranging from 0.6 to 10.5 liters. The bioreactor’s autoclavable design includes a borosilicate glass body and stainless steel head plate, offering robust heat transfer capabilities or gentle temperature control via a water jacket. It integrates seamlessly with bioprocess controllers and supports various impeller designs, including Rushton and marine blades. The BioFlo® 320 is compliant with GMP standards, ensuring suitability for regulated environments, and features easy cleaning with interchangeable vessel designs. Customization options and engineering support are available to meet your unique process requirements.

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Cultivates and Monitors Cell and Gene Therapies

The BioBLU® c Single-Use Bioreactors from Eppendorf are rigid-walled, stirred-tank systems engineered to elevate cell cultivation processes with unmatched scalability and precision. These bioreactors are ideal for the pharmaceutical and biotech sectors, providing a solution for the cultivation of human and animal cells, including stem cells, microbial cells, and cell aggregates for applications like gene therapy and vaccine production. With a working volume range from 100 mL to 40 L, these bioreactors support scalable production needs.

They integrate seamlessly with Eppendorf’s benchtop bioreactor systems, ensuring ease of incorporation in existing laboratory setups. The bioreactors feature optical pH sensors and dissolved oxygen monitoring to maintain optimal environmental conditions, while non-invasive sensor technology minimizes contamination risk. Available with pitched-blade impellers designed for efficient mixing, these bioreactors deliver precise control over process variables. Compliance with stringent sterilization standards guarantees operational safety, while fully weldable and easy-to-connect tubing facilitates maintenance and system adjustments. Additionally, customization options allow for flexible adaptation to specific project requirements, supported by Eppendorf’s engineering expertise.

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Facilitates Scalable Microbial Fermentation Processes

The BioBLU®f Single-Use Bioreactors from Eppendorf are specially designed for microbial applications, offering a rigid-walled stirred-tank format ideal for high-cell density fermentation. These bioreactors mimic traditional designs, ensuring effective mixing and mass transfer. They are suitable for producing monoclonal antibodies, insulin, and biofuels, with a working volume range of 65 mL to 3.75 L. Optimized for processes such as fermentation and cultivation, they integrate seamlessly with Eppendorf’s bioprocess controllers and selected third-party systems. With fully enclosed bearings and a sealed magnetic drive, they maintain sterility, while interior baffles and Rushton-type impellers ensure efficient mixing. Available in presterilized, autoclavable configurations, they support high agitation speeds and effective cooling, addressing the complex needs of the pharmaceutical, biotech, and biofuel industries while minimizing process risks.

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Facilitates Scalable Cell and Microbial Cultivation

The DASGIP® Parallel Bioreactor System from Eppendorf revolutionizes bench-top bioprocessing by enabling parallel operation of up to 16 bioreactors for scalable cell culture and microbial fermentation. This innovative system integrates DASware software solutions for superior process control, automation, and data management, ideal for producing monoclonal antibodies, biosimilars, biofuels, and biopolymers. Capable of handling glass and single-use vessels, it supports diverse applications from stem cell culture to bioethanol production through customizable process parameters like pH, dissolved oxygen, and temperature control. Operating at a power consumption of 480 W (without DASGIP Bioblock), it ensures energy efficiency, while its modular design allows for flexible integration within existing R&D and production environments. The system is equipped with robust automation including TMFC gas mixing, adaptable feeding strategies, and CIP capabilities, providing streamlined, contamination-free operations. Designed to meet industry standards, it offers a range of material options suitable for various process chemistries and ensures easy maintenance with user-friendly control units, making it an indispensable solution for pharmaceutical manufacturers and biotechnology companies.

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