Peristaltic pumps - Making.com

Aseptic ampoule filling and sealing solution

admin — Fri, 20 Sep 2024 12:15:26 +0000

Ensure precise dosing and secure sealing of sterile liquid pharmaceuticals in ampoules and vials with aseptic technology designed to maintain the integrity and purity of injectable products throughout high-speed production lines.

Fills, Seals, and Sterilizes Ampoules and Vials

The RSF Series by Marchesini Group offers aseptic filling and sealing solutions tailored for liquid pharmaceuticals. This equipment is designed to address precision and sterility challenges in processing ampoules and vials, using rotary piston or peristaltic pumps to ensure accurate dosing. The machine integrates seamlessly into high-speed production lines with continuous operation capabilities, handling a range of products from 1 ml ampoules to 30R vials. Energy efficiency is enhanced through electronically controlled draw-back features to prevent needle dripping, while nitrogen and gas flushing stations, compliant with ATEX rules, ensure optimal process conditions. The RSF Series supports a throughput of 6,000 to 24,000 pieces per hour, adhering to GMP standards for pharmaceutical manufacturing. Its compact design facilitates easy access and cleaning, supported by automatic loading and unloading features. Customization is available to fit diverse production line arrangements, ensuring it meets specific needs of pharmaceutical and biotech facilities.

The post Aseptic ampoule filling and sealing solution appeared first on Making.com.

Mohno pumps for efficient grape marc transfer

admin — Fri, 20 Sep 2024 10:39:48 +0000

Ensure gentle handling and uninterrupted flow of grape marc with low-vibration Mohno pumps, optimizing the transfer process while minimizing product degradation in winemaking operations.

Ensures Gentle, Steady Transfer and Pumping

The Mohno pumps FTF and PMS from Della Toffola represent a reliable solution for gentle pumping and transfer in winemaking and various industries. Their low-speed operation and hollow-shaft rotor deliver vibration-free, consistent flow essential for preserving product integrity. With models ranging from 100 to 1200 hl/h, they handle grape marc, crushed grapes, and more, ensuring gentle treatment critical for quality end-products like red wine and distilled spirits. Designed for continuous operation, these pumps integrate seamlessly into processing lines, aided by safety features like dry-run prevention and optional inverters and remote controls. Constructed with corrosion-resistant materials, they meet rigorous industry standards, and their design supports easy maintenance for reduced downtime.

The post Mohno pumps for efficient grape marc transfer appeared first on Making.com.

Lab-scale in-situ sterilizable bioreactor

admin — Fri, 20 Sep 2024 09:44:57 +0000

Ensure precision in your laboratory and pilot projects with this bioreactor, designed for seamless sterilization, mixing, and control, facilitating efficient scale-up from benchtop experiments to full production.

Sterilizes, Mixes, and Controls Bioprocesses

The KLF from Bioengineering AG is an in-situ sterilizable lab and pilot-scale glass bioreactor designed for precision in biopharmaceutical and chemical research applications. What sets this equipment apart is its ability to facilitate seamless batch, fed-batch, and perfusion processes, utilizing BioSCADA software for sophisticated control and data visualization. Capable of processing 1.6 to 2.5 liters, it’s ideal for developing monoclonal antibodies, insulin, and probiotic beverages. The bottom-drive mechanism supports efficient mixing with Rushton and propeller stirrers. Equipped with advanced probes for precise measurement of pH, dissolved oxygen, and temperature, the KLF ensures rigorous process control. With customizable gas and pump modules, it promises flexibility and scalability. Its compact, modular design supports easy scale-up and scale-down, reducing development time and cost. Designed with compliance in mind, it adheres to GMP standards and includes a CIP system for effortless maintenance. The bioreactor’s robust materials and efficient energy use make it a reliable choice for modern labs.

The post Lab-scale in-situ sterilizable bioreactor appeared first on Making.com.

Bioreactors for cell culture processes

admin — Fri, 20 Sep 2024 09:44:57 +0000

Efficiently cultivate sensitive cell lines with customizable bioreactors designed to optimize aeration, mixing, and temperature control for diverse production needs, from vaccines to nutraceuticals.

Cultivates and Processes Cell Cultures Efficiently

Bioengineering AG offers custom bioreactor systems designed for precision in cell cultivation. These bioreactors use innovative aeration strategies and wide impellers to accommodate shear-sensitive cells in applications ranging from monoclonal antibody production to skincare serum formulation. Capacities range from 30 to 25,000 liters, supporting continuous production with integrated perfusion systems. The BioSCADA software allows seamless automation and monitoring, enhancing efficiency with energy-saving temperature control and gas-mixing stations. Available in stainless steel, these systems comply with cGMP standards, ensuring compatibility and corrosion resistance. For flexible operation, optional CIP systems enable efficient cleaning, minimizing downtime, while comprehensive engineering support is available for tailored configurations.

The post Bioreactors for cell culture processes appeared first on Making.com.

Cleaning in place systems for bioreactors

admin — Fri, 20 Sep 2024 09:44:57 +0000

Ensure seamless sanitization with a mobile cleaning system designed to maintain product purity in bioreactor operations, reducing downtime and enhancing operational efficiency.

Automates and Optimizes Cleaning Processes

The CIP-Mobile Cleaning System from Bioengineering AG is engineered to streamline and enhance sanitation processes across various industries, including biopharmaceuticals, food, and cosmetics. This system excels in its ability to automatically clean complex equipment like fermentors and bioreactors through a meticulously controlled sequence involving pre-rinsing, alkaline cleaning, and final rinsing. Designed with flexibility in mind, it includes up to 28 programmable cleaning steps and is equipped with dual 200-liter tanks, a circulation pump, heat exchangers, and robust parameters control such as temperature and flow rates. Ideal for tackling challenges in operations ranging from pilot to large-scale production, this solution ensures surfaces in contact with products remain free of contaminants to avert cross-contamination. Constructed with high-grade materials, it supports recycling of cleaning solutions where applicable, promoting both economic and ecological benefits. The CIP-Mobile is compatible with industrial standards, featuring seamless integration with existing production lines through its PLC-controlled system, offering reliable documentation and control adjustments to meet stringent hygiene requirements.

The post Cleaning in place systems for bioreactors appeared first on Making.com.

Lab-scale fermentors for microbial cultivation

admin — Fri, 20 Sep 2024 09:44:57 +0000

Optimize microbial cultivation with lab-scale fermentors designed for precise control over fermentation processes, addressing challenges such as oxygen supply, temperature regulation, and automated dosing, ensuring high-quality yield consistency even in challenging environments.

Cultivates Microorganisms and Optimizes Fermentation Conditions

The stainless steel fermentor from Bioengineering is engineered to streamline microbial cultivation for the biopharmaceutical and nutraceutical industries. This equipment leverages advanced aeration strategies and precise control over oxygen supply, dosage, and temperature, ensuring optimal fermentation conditions for producing insulin, vaccines, and monoclonal antibodies. With capacities ranging from 30 to 50,000 liters, the fermentor accommodates both pilot and full-scale production. Designed for seamless integration into existing production lines, it features a PLC-controlled system for automated operations and offers compatibility with various control software, including BioSCADA, for intuitive management. Compliant with GMP standards, the fermentor includes integrated CIP systems for efficient cleaning and maintenance. Additionally, Bioengineering provides customization options to suit specific production needs, backed by over 50 years of industry expertise.

The post Lab-scale fermentors for microbial cultivation appeared first on Making.com.

Filling and closing system for nested containers

admin — Fri, 20 Sep 2024 09:42:28 +0000

Optimize liquid formulation packaging with a high-speed system designed for precise filling and secure closing of syringes and cartridges, ensuring minimal contamination and maximal efficiency in pharmaceutical and biopharmaceutical applications.

Fills and Closes Liquid Syringes and Cartridges

The SFM 5105 from Bausch+Ströbel is a versatile filling and closing machine designed for use in the pharmaceutical and biotech industries. This module stands out with its ability to handle a range of liquid formulations, using rotary piston pumps or alternative dosing systems like peristaltic pumps. The SFM 5105 is integral to producing pre-filled syringes and cartridges, efficiently automating the filling and closing processes with high precision. It accommodates nested containers from 0.5 to 10 ml, processing up to 4,300 items per hour. With its compact design, it seamlessly integrates into existing production lines, offering options for vacuum-assisted plunger insertion and gas flushing to maintain product integrity. Constructed to meet stringent pharmaceutical standards, it ensures low-particle operation in critical environments. The SFM 5105 supports CIP (clean-in-place) systems, optimizing maintenance and reducing downtime. Configurations are available to meet specific production requirements, backed by engineering support and software upgrades to ensure compliance and optimal performance.

The post Filling and closing system for nested containers appeared first on Making.com.

Tabletop vial and syringe filling system

admin — Fri, 20 Sep 2024 09:33:14 +0000

Ensure precise dosing and maintain sterility in small batch production with a compact filling system designed for efficient handling of vials and syringes.

Accurately Fills and Stopper Vials and Syringes

The Tabletop Vial and Syringe Filling System (CFS) from AST is a semi-automatic solution tailored for precise liquid dispensing. Ideal for small batch production, it integrates seamlessly with bench-top operations to fill, stopper, and weigh vials and syringes, catering to biopharmaceutical applications like vaccines and gene therapies. Its compact design fits within isolators or bio-safety cabinets, ensuring sterility and compliance with cGMP standards. The system utilizes a peristaltic or optional rotary piston pump for accurate dispensing, minimizing product shear. With real-time volumetric monitoring and electronic batch reporting, it supports meticulous documentation and regulatory adherence. The intuitive HMI touchscreen enables detailed process control, accommodating diverse material viscosities and container sizes. Customizable features, including inert gas purging and single-use fluid paths, enhance versatility, while the robust construction in pharmaceutical-grade materials guarantees reliability and easy maintenance.

The post Tabletop vial and syringe filling system appeared first on Making.com.

Compact filler and closer for vial processing

admin — Fri, 20 Sep 2024 09:10:52 +0000

Efficiently streamline your vial filling and closing processes with a compact machine designed for precision and ease of integration, minimizing downtime with rapid changeovers and waste-reducing features.

Fills, Stoppers, and Caps Vials Efficiently

The TGM M100 Filler and Closer from Adelphi Manufacturing excels in precise filling, stoppering, and capping of vials, ideal for industries ranging from pharmaceuticals to cosmetics. Featuring peristaltic, volumetric displacement, or vacuum pump options, it offers flexibility for various product types like serums and essential oils. Capable of handling up to 2,400 containers per hour, the M100 supports efficient production with a filling accuracy of +/-0.5%, significantly reducing waste. Designed with cleanability in mind, it offers a swift 15-20 minute changeover and is GMP-compliant, facilitating seamless integration into cleanroom environments. Its “No bottle no fill” and “No cap” sensors optimize line efficiency by minimizing material loss, making it a vital component for packaging and processing departments looking to streamline their operations.

The post Compact filler and closer for vial processing appeared first on Making.com.

Integrated Uv-vis spectrophotometer for dissolution testing

admin — Tue, 03 Sep 2024 15:41:57 +0000

Streamline your dissolution testing with real-time UV-Vis analysis, optimizing accuracy and efficiency in pharmaceutical sample assessment.

Performs Real-Time UV-Vis Dissolution Analysis

The ATS Xtend™ UV Online from SOTAX revolutionizes pharmaceutical dissolution testing by integrating UV-Vis analysis directly into the dissolution process. This system enables simultaneous real-time analysis across multiple test sites, significantly shortening analysis time and reducing operational costs. Designed for a variety of applications including tablets, capsules, gels, and more, it ensures seamless data integration and integrity. The inclusion of flexible sampling and monitoring functions enhances precision and reduces manual steps, while the motorized AutoLift™ and HollowShaft™ options offer flexible, automated sampling. Its integration capabilities allow for the connection of various spectrophotometers, utilizing diode array or double beam technology, for single wavelength or multi-component analysis. The setup supports streamlined networking, consolidating data into a single report, while maintaining compliance with industry standards. The system is also engineered for easy cleaning with automated flush technology, ensuring minimal downtime. Customizable to meet specific operational demands, the ATS Xtend™ UV Online is ideal for pharmaceutical manufacturers and research labs seeking efficient, accurate dissolution testing solutions.

The post Integrated Uv-vis spectrophotometer for dissolution testing appeared first on Making.com.