Cleans and Sanitizes Intermediate Bulk Containers

The CONSERVE 360® from ACG is a sophisticated bin washing system designed to meet the stringent cleaning demands of pharmaceutical and nutraceutical manufacturers. It features a crevice-free, double-walled construction that ensures compliance with cGMP standards. The system employs high-pressure jet technology with uniquely designed European nozzles, eliminating dead zones and preventing cross-contamination. It supports user-defined recipe-based cleaning, offering fully automated operation with pre-programmed wash cycles for repeatable results. Significant water savings are achieved, reducing consumption by 60%, and it integrates seamlessly with online conductivity measuring systems for real-time verification and traceability. Built to sustain high water-line pressures, the CONSERVE 360® provides flexibility in pump settings, and its materials offer superior corrosion resistance, making it suitable for a variety of solid pharmaceutical and nutraceutical applications.

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Performs High-Speed Granulation and Mixing

The HSM 2000 X·ONE from ACG is a high-shear mixer granulator engineered for precision and efficiency in large-scale batch processing of pharmaceutical and nutraceutical products. Its unique design features a Z-shaped impeller and multi-blade chopper, optimizing centrifugal force for uniform binder distribution and minimizing dead zones. This equipment excels in wet granulation and mixing, ideal for producing tablet granules, vitamin supplements, and probiotic capsules.

Capable of handling working volumes from 600 to 1,600 liters, it integrates seamlessly into a granulation train or operates as a standalone unit. The system is equipped with the ACG X·ONE command process control system, providing secure, intuitive monitoring compliant with ATEX, GAMP 5, and 21 CFR Part 11 standards. The MOST™ (Maximum Operator Safety Technology) ensures operator safety, while the non-vented, fully contained design enhances the work environment.

It supports applications in processing departments within the pharmaceutical and nutraceutical industries, handling powders and granules with high-speed efficiency. Maintenance is streamlined with wash-in-place (WIP) systems, facilitating easy cleaning and reducing downtime for continuous operation.

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Processes and Mixes Powders into Uniform Granules

The HSM 300 X·ONE high-shear mixer granulator by ACG is engineered to streamline the granulation and mixing processes crucial for pharmaceutical and nutraceutical production. Utilizing a unique product bowl geometry and Z-shaped impeller, it achieves uniform mixing by maintaining a roping flow regime, which facilitates faster process stabilization and optimal particle-size distribution. Designed for small production batches, it excels in processing powders into granules for end-products like paracetamol and ibuprofen tablets or omega-3 softgels. Capable of handling a working volume between 90 and 240 liters, the HSM 300 X·ONE integrates seamlessly into granulation trains or can function independently. Equipped with ACG’s X·ONE command process control system, it provides intuitive control and monitoring, compliant with ATEX, GAMP 5, and 21 CFR Part 11 standards. Enhanced safety is guaranteed through the MOST™ operator safety technology, capable of withstanding 12-bar pressure shocks, ensuring operations resume quickly post-event. Efficient cleaning is facilitated by a wash-in-place system, reducing downtime and maintaining high production yield.

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Mixes and Granulates Pharmaceutical Powders

The HSM 1200 High-Shear Mixer from ACG is a critical component for pharmaceutical and nutraceutical manufacturers focusing on efficient granulation and mixing. Designed to handle large production batches, this mixer is known for its superior centrifugal force achieved through a Z-shaped impeller and multi-blade chopper. It ensures uniform binder distribution and optimal particle-size distribution, especially valuable in producing effervescent tablets and protein powders.

Operating with a working volume ranging from 360 to 960 liters, it seamlessly integrates into granulation trains or functions independently, offering flexibility in production lines. Its PLC-controlled system promotes batch operations and high-speed processing, ensuring consistent output. The HSM 1200 reduces energy consumption via optimized motor control and enhances wash-in-place efficiency with integrated cleaning nozzles for swift and dust-free maintenance.

Constructed to adhere to GMP compliance with an ergonomic design, it offers the advantage of easy access for operation and maintenance. With multiple systems for charging and discharging and a highly efficient vent air filtration, the machine supports smooth and uncontaminated processing cycles. Configurations are available to meet your specific operational demands, backed by ACG’s expertise from handling over 1,000 formulations.

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Mixes and Granulates Pharmaceutical and Nutraceutical Products

The HSM 150 from ACG exemplifies efficient granulation and mixing solutions tailored to pharmaceutical and nutraceutical manufacturing needs. Designed with an ergonomic product bowl and a Z-shaped impeller, it ensures even binder distribution and superior particle-size uniformity, crucial for producing effervescent tablets, protein powders, and more. With a working volume ranging from 45 to 120 liters, it’s perfect for small batch production. The system’s compatibility with granulation trains or standalone use enhances flexibility, while integrated cleaning nozzles facilitate easy maintenance. Constructed to meet GMP standards, the HSM 150 supports seamless process integration and reliable operation in demanding environments.

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Processes and Coats Pharmaceuticals and Nutraceuticals

The MINIQUEST F from ACG is designed for small-scale pharmaceutical and nutraceutical production, providing unparalleled flexibility in R&D environments. This compact fluid bed processor excels in granulation, drying, and Wurster coating processes, featuring an innovative venturi-based fluidisation system that eliminates the need for electrically powered blowers, simplifying installation and reducing operational costs. With a working volume accommodating batches from 225 ml to 750 ml, it’s perfect for handling diverse product types such as powders and granules. The integrated peristaltic pump minimizes system footprint, while the 5μ sock filter ensures dust-free operations, suitable for academic settings and early production stages. Its compliance with GMP standards facilitates seamless integration into existing processing lines.

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Granulates, Dries, and Coats Lab-Scale Materials

The QUEST FB from ACG is a versatile laboratory-scale fluid bed combo designed for pharmaceutical and nutraceutical R&D applications. What sets this unit apart is its ability to seamlessly switch between top-spray granulation and Wurster coating within a single, retrofittable container, making it ideal for flexible process development. It operates using efficient airflow distribution and a programmable logic controller (PLC) integrated with a weighing scale for precise spray-rate measurement. The unit accommodates a working volume from 0.3 to 3 liters, suitable for bench-top R&D. Its touchscreen HMI and multiple air distribution plates allow easy operation and customization. Constructed with high-quality materials, it ensures compliance with industry standards, while its user-friendly design supports quick setup and maintenance.

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Performs Drying and Granulation of Powders

The FBE 125 from ACG is a versatile fluid bed granulation and drying system tailored for high-precision pharmaceutical and nutraceutical manufacturing. Utilizing a dynamically controlled fluid bed, it excels in drying and granulating powders and granules, ideal for products like effervescent tablets and probiotic capsules. With a capacity of up to 125 liters per batch, it integrates seamlessly into automated production lines, featuring a 21 CFR part 11-compliant control system for regulatory assurance. Its efficient, state-of-the-art filter bag shaking system ensures thorough filtration with minimal air consumption, enhancing energy efficiency. Available in corrosion-resistant stainless steel, it supports customization with options for standalone or integrated wash-in-place systems, ensuring easy maintenance and reduced downtime.

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Granulates and Dries Pharmaceutical and Nutraceutical Materials

The FBE 1800 X•ONE from ACG is a sophisticated fluid-bed system designed for pharmaceutical and nutraceutical processing. This unit excels in granulating and drying tasks with precision, making it ideal for producing effervescent tablets, dietary supplements, and other high-quality granules and powders. The FBE 1800 X•ONE operates with a working volume range from 525 to 1,956 liters, and effectively handles batches up to 1,800 liters, meeting high throughput demands. Equipped with the MOST™ (Maximum Operator Safety Technology) concept, it ensures safe and efficient operation with 12-bar pressure-shock resistance. Compliance with ATEX, GAMP 5, and 21 CFR Part 11 highlights its suitability for critical applications. Tailored for seamless integration, it features customized charging, discharging, and wash-in-place (WIP) systems, ensuring quick changeovers and maintaining production uptime. The non-vented, fully contained design minimizes environmental risk, while the unique C-flanges and X•ONE inflatable seals provide additional safety during processing.

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Processes and Mixes Powders into Granules

The GT Series from ACG is an integrated granulation train combining high-shear mixing and fluid bed technology, engineered specifically for the pharmaceutical and nutraceutical industries. This system excels in processing pharmaceutical powders into granules and is capable of handling a variety of end-products, including effervescent tablets and multivitamin capsules. Utilizing a closed-loop system, it ensures precise granulation, drying, and material transfer, significantly reducing dust and product loss. With a compact footprint and through-the-wall construction, the GT Series facilitates easy maintenance and clean operations in compliance with GMP standards. The equipment supports both batch and continuous operations, offering flexible configurations to match diverse formulation needs. Enhanced by energy-efficient components, the GT Series not only minimizes operational costs but also complies with rigorous pharmaceutical and nutraceutical production protocols.

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