Fills and Stopper Nested Syringes and Vials

The Extrafill 10 by Marchesini Group is a high-speed, automated filling and stoppering machine specifically engineered for the pharmaceutical and biotech sectors. It excels in aseptic processing for liquid formulations, handling a range of container formats including nested syringes, vials, and cartridges. The machine employs a ten-head filling system with brushless motor-driven movements, ensuring precise dosing and reducing the risk of contamination thanks to its Balcony Style design, which promotes optimal airflow. Unique features such as the piston and peristaltic pump interchangeability, alongside in-process weight control, enhance operational flexibility. Capable of processing up to 36,000 syringes per hour, the Extrafill 10 integrates seamlessly into production lines with its denesting and detraying units, along with reject and recover systems for faulty containers. Compliance with GMP standards is ensured, with options for installation under LAF, RABS, or in isolator environments, offering a high degree of process control and contamination prevention. Additionally, the system facilitates efficient maintenance access and format changes, vital for minimizing downtime in high-demand environments.

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Assembles and Inspects Pharmaceutical Syringes and Containers

Groninger’s Syringe Assembly Machines offer an integrated solution for the precise assembly and inspection of pharmaceutical primary packaging, including syringes, vials, and cartridges. These machines excel in handling delicate processes such as plunger rod insertion, labeling, and safety device assembly, ensuring the integrity of prefilled syringes used for a range of medical applications, from insulin delivery to vaccination. Capable of processing up to 600 objects per minute, these machines boast a modular design that allows for easy line integration and expansion with features like backstop mounting and advanced inspection systems. Their electromotive mechanisms ensure minimal energy consumption while maintaining high precision assembly. Stainless steel construction provides durability and compliance with GMP and FDA standards. Cleaning is simplified with an integrated tray loading and buffering system, complemented by comprehensive engineering support for customization to meet specific production requirements.

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Fills and Assembles Aseptic RTU Containers

The flexfill from groninger is an advanced filling machine designed for precise handling of aseptic pharmaceutical products in ready-to-use (RTU) containers. It specializes in filling and closing pre-sterilized syringes, vials, and cartridges, making it ideal for pharmaceuticals such as pre-filled syringes and vial-based vaccines. Employing no-touch transfer (NTT) and E-Beam decontamination options, it ensures contamination-free transfer into aseptic environments. Handling capacities range from small pilot batches to high-speed industrial production, accommodating up to 1,000 containers per minute, all controlled via a PLC system for seamless integration into production lines. Meeting strict GMP compliance, flexfill optimizes throughput with features like smartfill technology for minimal product loss and robust energy efficiency. Stainless steel construction ensures chemical compatibility, and automated in-process control (IPC) assures precise filling accuracy, making it a reliable choice for complex biopharmaceutical manufacturing needs.

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Fills, Stops, and Seals Aseptic Liquid Pharmaceuticals

The Labworx Benchtop Filling Machine from Groninger offers semi-automatic precision for small batch pharmaceutical and biopharmaceutical production. Utilizing state-of-the-art filling, stoppering, and sealing modules, it ensures aseptic conditions for sterile liquid injectables, vaccines, and clinical trial doses. Compact and benchtop-friendly, its design allows seamless integration into laboratory environments and small production lines.

The Labworx system incorporates a choice of peristaltic or rotary piston pumps for precise volume control, accommodating a filling range from 0.1ml to 250ml. Its modular design supports various container types, including vials, pre-filled syringes, and cartridges, with an output of up to 10 containers per minute. The machine’s hygienic design, compliant with 21 CFR Part 11, ensures adherence to pharmaceutical manufacturing standards.

Automation features include an intuitive human-machine interface accessible via HTML5-enabled devices, allowing for remote operation and monitoring. The system supports in-process control with options for single-use components, enhancing sterility and reducing cross-contamination risks. Expedited delivery and quick-connect technology minimize downtime, further accelerating time-to-market for research or commercial applications.

Materials of construction, including stainless steel, offer robustness and chemical compatibility, while standard connections enhance process integration. Customization options are available to meet specific laboratory requirements, with full engineering support provided by Groninger.

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Fills and Seals Aseptic Vials, Syringes, and Cartridges

The flexfill from groninger is a modular aseptic filling machine designed to streamline the production of sterile liquid pharmaceuticals. Its unique modular design allows for rapid deployment and customization, meeting medium production volumes for pharmaceutical manufacturers and CDMOs. The system efficiently handles debagging, transfer, opening, filling, closing, denesting, and sealing processes for vials, syringes, and cartridges. Featuring flexible filling systems, including rotary piston and peristaltic pumps, it accommodates a variety of product viscosities and oxygen-sensitive formulations, with optional gassing and vacuum capabilities. Compliant with major regulatory standards, flexfill ensures high process reliability with automated clamping, cutting, and In-Process-Control (IPC) to maximize output. The hygienic design supports fast cleaning, integrating into existing lines with ease and leveraging groninger’s high-end capping technology for minimized particle generation during sealing. Available with advanced camera systems for precise quality control, it meets GMP standards, providing pharmaceutical and biopharmaceutical manufacturers with a reliable solution for aseptic filling.

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Fills and Seals Syringes, Vials, and Cartridges

The Syfill from GF is a versatile and compact filling and closing machine tailored for pharmaceutical and healthcare industries. It processes nested pre-sterilized syringes, vials, and cartridges with precision, accommodating various product types including liquids, slurries, and viscous formulations. Working on an intermittent automatic mode, the Syfill is suitable for injectable end-products such as vaccine vials and insulin cartridges. It integrates seamlessly into production lines, capable of standalone operation or within a full line including debagging and delidding units. The machine offers flexible filling systems ideal for handling emulsions and freeze-dried products. With a robust design optimized for pharmaceutical processing, it supports operational efficiency and GMP compliance. The Syfill also provides customization options to meet specific operational needs, complemented by engineering support for integration into existing systems.

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Fills and Closes Nested Containers with Precision

The SFM Series from Bausch+Ströbel excels in efficiently filling and closing nested containers like vials, cartridges, and disposable syringes. Designed with pharmaceutical production in mind, these machines integrate seamlessly into your line, offering both fully automatic and manual feeding options for versatility. This equipment stands out with its ability to employ rotary piston, peristaltic, or time-pressure dosing systems, depending on the specific needs of your biopharmaceutical operations. Critical for producing vaccines, blood plasma products, and injectable medications, the SFM Series ensures precision with its vacuum-assisted filling that minimizes air entrapment, thus enhancing product integrity.

Capable of processing up to 60,000 items per hour, these machines are built with process reliability in mind, incorporating in-process control and vacuum-assisted closures. The units maintain production parameters with ease and allow for short set-up times. Energy efficiency is heightened through optimized laminar airflows and reduced particle generation when sealing, contributing to both cost reduction and product safety.

Constructed for compliance with DIN, GMP, and FDA standards, the SFM machines support CIP/SIP systems for thorough, contamination-free cleaning, aligning with stringent pharmaceutical regulations. With additional options like RABS and isolators for aseptic environments, the SFM Series ensures your production remains consistent and compliant. Customizations and configurations are supported, backed by Bausch+Ströbel’s comprehensive engineering assistance.

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Fills and Closes Sterile Liquid Pharmaceuticals

The GENiSYS® R from AST is a versatile aseptic small batch filling and closing machine designed for pharmaceutical and biologics manufacturers requiring high precision in sterile drug production. This machine integrates advanced robotic systems to efficiently fill, close, and seal vials, syringes, and cartridges, ensuring compliance with cGMP regulations. Capable of processing various container formats, it supports clinical trials and small-batch commercial production of monoclonal antibodies, vaccines, and personalized medicines. The system offers a modular configuration, allowing for seamless integration with lyophilizers and other packaging systems. Automated in-process controls and environmental monitoring enhance product yield and sterility assurance. Constructed with pharmaceutical-grade materials, the GENiSYS® R provides reliable, contamination-free operation with options for isolator or RABS aseptic barriers.

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Processes and Seals Aseptic Liquid Batches

The ASEPTiCell® from AST is an advanced aseptic fill-finish system tailored for small to medium batch production demands in pharmaceutical and biotech industries. It integrates robotic automation and modular systems, allowing efficient processing of ready-to-use vials, syringes, and cartridges. The ASEPTiCell® features in-process weight verification and environmental monitoring to ensure compliance with stringent cGMP requirements. Designed for applications including biologics, vaccines, and toxic materials, the system supports production of products like monoclonal antibodies and mRNA vaccines. With a compact footprint, it offers flexible module configurations, including lyophilization and isolator-barrier options, enhancing sterility and operational efficiency. Automated decontamination with hydrogen peroxide and rapid changeover capability further optimize production workflows. Compliant with pharmaceutical-grade material standards, the ASEPTiCell® is engineered for enhanced operational integration and ease of maintenance.

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Fills and Seals Liquid Monodose Units

The N500 from TGM – TECNOMACHINES s.r.l. is engineered to enhance filling and sealing processes for liquid monodose units and cartridges in pharmaceutical and cosmetic industries. This high-precision machine integrates automatic loading and multi-dose product handling, accommodating simultaneous filler operations with its versatile system. With a throughput of up to 1800 cartridges per hour, the N500 ensures efficient production for single-dose cough syrups to anti-aging serums. It supports seamless integration into existing production lines with advanced PLC control and automatic loaders. Its energy efficiency, derived from optimized motor controls, and construction from corrosion-resistant materials, ensures durability and reduced operational costs. Compliance with industry standards like GMP makes it suitable for regulated industries. The machine’s design facilitates easy cleaning and maintenance, featuring CIP systems for minimal downtime. Customization options are available, backed by engineering support to tailor the machine to your specific requirements.

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