Oxygenates Wort for Fermentation Initiation

The GEA WORTSTAR Craft Wort Aeration Unit is designed for craft brewers seeking to enhance wort oxygenation with precision. This semi-automatic system uses a unique bubble size distribution method by creating a partial vacuum when wort flows into the aeration nozzle, entraining air and increasing oxygen uptake. Applicable in craft brewing and beverage production, it supports the fermentation of beers like pale ale, IPA, and lager. With a throughput of 30 to 195 hl per hour, the unit seamlessly integrates into your existing setup, offering continuous, hygienic operation with easy CIP cleaning. Designed with an annular gap nozzle for sterile air introduction, it ensures stable fermentation and superior beer quality while maintaining efficient energy use.

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Cultivates and Ferments Cells for Food Production

The Axenic® C Bioreactor from GEA is an industrial-scale system specifically designed for cultivating mammalian and eukaryotic cells in the food industry, focusing on applications like cultivated meats and precision fermentation. Utilizing a stirred tank reactor approach, it allows both fed-batch and continuous cultivation processes, making it suitable for producing cultured chicken breast and plant-based protein patties. The system integrates GEA’s Virtual Bioreactor Testing technology, which employs digital twin simulations to optimize shear forces, oxygen transfer rates, and temperature settings tailored to your specific cell cultures.

Importantly, the Axenic® C is fully automated, featuring the GEA Codex® process control platform for enhanced operational stability and reduced manual intervention, minimizing contamination and maximizing process repeatability. It offers multiple gas connections and perfusion capabilities to manage gas dissolution and remove inhibitory by-products, ensuring consistent cell growth and high yield production. Compliance with food industry regulations makes it ideal for innovators in cultivated fats and new food sectors. The system supports CIP for effective cleaning, and its modular design can be customized with expert engineering support to fit seamlessly into both upstream and downstream processes, enhancing your production line’s efficiency and sustainability.

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Cultivates and Ferments Microbial Cells at Scale

The GEA Axenic® M bioreactor system, designed for microbial and precision fermentation, offers a specialized solution tailored for the burgeoning needs of the food industry, particularly in the areas of alternative proteins and new food products. This industrial-scale system employs a stirred tank reactor approach to enable both fed-batch and continuous cultivation, allowing for efficient growth of engineered cells. What sets the Axenic® M apart is its focus on regulatory compliance and adaptability to the distinctive requirements of microbial processes, addressing specific needs such as oxygen transfer and temperature control using its Virtual Bioreactor Testing technology. This advanced digital twin simulation tool allows for precise optimization of the system, ensuring energy-efficient operation and optimal yield.

Capable of handling industrial-scale operations, the Axenic® M is fully automated, utilizing GEA’s Codex® process control platform for process stability and safety, reducing manual intervention and potential for error. Designed to integrate seamlessly into existing production lines, this system supports continuous and pilot-scale operations, catering to food industry manufacturers and fermentation technology developers. With options for external cooling loops, it maintains temperature consistency and mitigates cleaning risks, ensuring a high level of production repeatability. The Axenic® M also supports comprehensive customization, providing consultation and engineering support to fine-tune the system to specific production needs.

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Scales Up Cell Cultivation and Fermentation Processes

The GEA Axenic® P from GEA Group is a pilot-scale bioreactor designed to facilitate the transition from laboratory to industrial-scale cell cultivation and fermentation. This versatile bioreactor is equipped with comprehensive data collection and process optimization features, enabling exact control over conditions vital for producing cultivated meat, precision-engineered dairy products, and fungal mycelium. By emulating conditions similar to industrial environments, it allows for seamless upscaling and testing of new food processes.

With a flexible, fully reusable design, the Axenic® P supports a variety of cell types and configurations, incorporating multiple inlets for media and gas delivery. It is semi-automated for integration into existing setups or to function as a standalone unit. Using a virtual modeling system, it predicts cell behavior during scale-up, ensuring process stability and yield. The system emphasizes sustainability and efficiency, utilizing split range control for oxygen delivery and integrating CIP solutions for minimal maintenance downtime. Suitable for diverse industries such as food and pharma, the Axenic® P meets the evolving demands of R&D in alternative protein and new food production.

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Scales and Optimizes Cell Culture Processes

The PBS-15 Vertical-Wheel Bioreactor from PBS Biotech is designed to advance your cell culture processes by integrating the unique vertical-wheel design for superior mixing and scalability. This bioreactor supports applications in biopharmaceuticals, cell therapy, and regenerative medicine, producing high-quality end products like CAR-T cell therapy and microcarrier-based stem cell cultures. With a maximum working volume of 15 liters, it efficiently scales up from bench-top experiments to clinical production. Equipped with a touchscreen interface, it offers intuitive process control and customization, allowing for seamless medium exchange and sampling via an adjustable height harvest valve. It supports both single-use and reusable sensor configurations, ensuring operational flexibility. The PBS-15’s software allows for remote monitoring and data storage in compliance with 21 CFR Part 11 standards. Designed for easy cleaning and maintenance, it is ideal for pharmaceutical manufacturers, cell therapy developers, and research laboratories looking to optimize their cell culture workflows.

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Cultures and Scales Therapeutic Cells

The PBS-3 Vertical-Wheel Bioreactor from PBS Biotech is designed to optimize your cell therapy production processes. This single-use, stirred suspension bioreactor offers customizable process parameters, effectively addressing complex needs in therapeutic cell cultivation, such as mixing, monitoring, and sampling. It caters to applications including MSC, hiPSC, CAR-T, and NK cell therapies, and is suitable for biotech and pharmaceutical industries. The bioreactor is engineered to simplify the scale-up process from laboratory to clinical trials, ensuring smooth transition to larger volumes. Featuring real-time data monitoring and process control, it allows remote access for adjustments and alarms via a secure interface. The system supports the integration of single-use or reusable sensors for DO and pH, meeting FDA and GMP standards. Available as a compact, bench-top system, it fits effortlessly into research and development environments, making it a versatile addition to your cell therapy production line.

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Cultivates and Expands Therapeutic Cells at Scale

The PBS-80 Vertical-Wheel Bioreactor from PBS Biotech is engineered for large-scale manufacturing of therapeutic cells. It uses a unique vertical-wheel design that optimizes hydrodynamic conditions for anchorage-dependent human cells, such as cell aggregates and cells grown on microcarriers. With an 80-liter working volume, it meets the demands of both clinical stage production and commercial scale manufacturing. This bioreactor integrates seamlessly into your processing line, featuring an adjustable height harvest valve for efficient medium exchange and harvesting. Equipped with a touchscreen interface, it allows for intuitive customization and real-time process monitoring, including remote control capabilities. The PBS-80 supports advanced automation and ensures compliance with 21 CFR Part 11 cGMP standards. Available with single-use or reusable sensors, it offers flexibility in operation while being easy to clean and maintain. With PBS Biotech’s engineering support, you can tailor this bioreactor to meet specific production needs, making it ideal for producing CAR-T cell therapies, NK cell therapies, and other stem cell products.

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Cultures and Expands Stem Cells and MSCs

The PBS-Mini Vertical-Wheel Bioreactor from PBS Biotech is a cutting-edge solution designed for precise and scalable cell culture processes. Its unique Vertical-Wheel technology facilitates gentle yet effective mixing, optimizing conditions for stem cell culture and T cell expansion. Ideal for biopharmaceutical and cell therapy applications, this bioreactor accommodates single-use vessels with working volumes of 0.1L or 0.5L, providing flexibility for various research and development needs. The system’s compatibility with incubators allows for controlled temperature and gas conditions, essential for reproducible results. Constructed with materials that meet regulatory standards, it ensures compliance for first-in-human clinical trials. The PBS-Mini is engineered for seamless integration into laboratory and pilot-scale operations, featuring removable caps for sterile sampling and harvesting, and is supported by comprehensive user resources and customization options.

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Facilitates Gentle Aseptic Mixing in Bioreactors

The Zero-g Biomixer from Metenova is a magnetically coupled, bottom-mounted mixer specifically designed for aseptic and sterile bioreactor applications. Its patented Zero Gravity Technology features a magnetic bearing system that minimizes wear, ensuring reliable operation and reduced maintenance. This technology creates a magnetic cushion, allowing for gentle, efficient mixing with minimal risk of damage to impellers, making it well-suited for producing high-purity biologics, including monoclonal antibodies and DNA/RNA vaccines. The mixer supports customization of impeller designs to meet specific process requirements, reducing the need for revalidation. By eliminating mechanical seals, it enhances aseptic integrity, and its robust design withstands higher forces associated with large bioreactor vessels. Additionally, it is engineered for quick integration and minimized downtime with a focus on CIP/SIP (Cleaning-In-Place/Sterilization-In-Place) for contamination-free cleaning, supporting compliance with stringent industry standards like GMP and FDA.

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Controls and Optimizes Bioreactor Operations

The Single Use Bioreactor Control System offered by Marubishi Bioengineering is a customizable solution designed to seamlessly integrate into your biopharmaceutical production line, particularly when managing complex cell cultures and monoclonal antibody production. Its standout feature is the ability to tailor the control system according to your specific bioprocessing strategies, ensuring optimal performance and compliance with unique operational requirements.

This system excels in managing single-use bioreactors, commonly used in generating recombinant proteins and viral vectors intended for gene therapy. It supports continuous operations with an integrated SIP (Sterilization-In-Place) and CIP (Clean-In-Place) functionality to maintain sterility and operational efficiency.

Built for versatility, the system can manage various processing capacities, integrating smoothly with existing upstream and downstream processes. With a focus on energy efficiency, it incorporates advanced software for precise environment control, reducing energy consumption and system downtime.

Engineered from high-grade materials suitable for stringent biopharmaceutical conditions, it stands robust against potential corrosion, ensuring longevity and reliability. Certified to adhere to cGMP and FDA standards, this system is designed for the highest levels of compliance in the bioprocessing and life sciences industries.

For enhanced usability, it includes comprehensive support for system customization, remote monitoring, and flexible operational adjustments, ensuring it meets the varied demands of biotech and pharmaceutical applications.

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