Remediates and Purifies Cannabis and Hemp Extracts

The CRC-003 Inline Color Remediation Column & Chromatography Skid from Precision Extraction Solutions addresses the intricate needs of cannabis extractors and hemp processors. This equipment excels in efficiently remediating and purifying extracts, removing unwanted contaminants like heavy metals and pesticides, using a versatile inline system. With a liquid-jacketed vessel to maintain processing temperatures and vacuum, its streamlined design ensures easy fluid transfer via a nitrogen manifold, seamlessly integrating into any hydrocarbon extraction line. The CRC-003 operates continuously, processing liquid substrates for the production of high-quality THC concentrates, hemp CBD oil, and full-spectrum hemp oil. Its construction from 304 stainless steel offers durability and chemical resistance, while compliance with Class 1, Division 1 standards ensures safe operation. Rated for temperatures down to -40°C and pressure up to 350 PSIG, this system requires minimal maintenance, backed by a 1-year warranty and on-site training.

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Facilitates Separation and Purification Processes

The glass-lined steel columns from GMM Pfaudler are engineered to navigate the challenges of handling corrosive chemicals in the chemical, pharmaceutical, food, and energy industries. These columns are designed to support various separation and purification processes, including distillation, absorption, and evaporation. They stand out for their corrosion-resistant properties, utilizing a glass-lined steel construction that withstands harsh environments while ensuring product purity.

Integrating seamlessly into production lines, they accommodate custom-sized solutions and are optimized for continuous operations. These columns are particularly effective in the production of ultra-clean and ultra-pure chemicals, such as solvent recovery in the pharmaceutical sector and biofuel purification.

Processing capabilities are enhanced with options for jacketed or non-jacketed configurations, tailored nozzle locations, and various support mechanisms such as tantalum clad rings that meet stringent DIN 28007-2:2017-04 standards. The equipment is PLC-controlled, offering remote monitoring to ensure optimal operation and maintenance efficiency.

Available in multiple configurations, the columns can be combined with internals made from ceramic or PTFE from the Edlon product line, enhancing their adaptability to specific process requirements. GMM Pfaudler provides comprehensive engineering support, assisting with pilot testing and scale-up to ensure successful system integration.

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Performs HPLC-Integrated Dissolution Testing

The ERWEKA Dissolution HPLC On-/Offline System is a semi-automatic solution designed to enhance pharmaceutical testing precision. By integrating the DT 950 dissolution tester with HPLC online analysis, it automates up to five of eight dissolution steps, ensuring USP/EP/JP compliance. It tackles common contamination issues utilizing double filtration with the maintenance-free PVP 820 pump and AFC 825 filter changer, capable of filtrations up to 0.22 µm. Disso.NET software orchestrates the entire process, offering extensive data management and method development tools. Ideally used for testing pharmaceutical tablets and powders, this system supports seamless sample collection and analysis, significantly improving accuracy and throughput in R&D and quality control operations. Customizable with optional spectrophotometers and compatible with major HPLC brands, it facilitates night-time operation without manual intervention, addressing the need for high-efficiency dissolution testing.

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Purifies and Separates Compounds Efficiently

The Pure Chromatography Systems from BUCHI offer compact and automated solutions for efficient purification and separation in pharmaceutical, biotechnology, chemical, and food industries. Designed for flexibility, these systems combine flash and preparative HPLC capabilities within a single unit, allowing precise compound isolation. Ideal for applications ranging from biopharmaceuticals to natural products, these systems ensure minimal laboratory space usage with high safety standards, featuring a closed fraction collector bay for clean air. The integrated UV and ELSD detection, combined with RFID technology, enhances accuracy and mitigates risk. With user-friendly interfaces minimizing training time, these systems optimize lab operations with remote control and robust leak and pressure sensors. Capable of both liquid and solid sample injection, they support a range of applications. The Pure systems meet stringent laboratory requirements, offering scalable solutions with easy maintenance.

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Facilitates Precise Separation and Purification Processes

The Pure Essential Flash Chromatography System from BUCHI is a highly adaptable solution for laboratories seeking efficient separation and purification of a range of substances, such as pharmaceuticals and specialty chemicals. Its modular design supports your evolving needs with features like a robust 50 bar pump and configurable UV detection for precise chromatography. Ideal for industries including pharmaceuticals and biotechnology, this system optimizes your process with reliable separation of compounds like APIs, vitamin E, and Omega-3 supplements. This compact, fully automated setup fits seamlessly into tight lab spaces, enabling intuitive operation through advanced software that simplifies method programming and adjustments. Additionally, the system allows for extensive customization with various cartridge holders and sample loading options, catering to both liquid and solid products. Safety and efficiency are enhanced with intelligent automated functions and robust construction, while interchangeable glass columns and optional fraction collectors expand its capabilities. Designed to meet rigorous industry standards, the Pure Essential System ensures precise, scalable performance, making it indispensable for any lab focused on high-purity outcomes.

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Purifies and Separates Biopharmaceutical Components

AUSTAR’s custom chromatography system is designed to meet the precise requirements of pharmaceutical and biotech industries. This versatile equipment is crucial for purifying proteins, nucleic acids, and complex molecules in biopharmaceutical production. It utilizes a multi-method chromatographic approach—including gel filtration, ion exchange, and affinity chromatography—to ensure high-purity output for applications like monoclonal antibodies and mRNA vaccines.

The system is constructed with corrosion-resistant stainless steel (316L/1.4435) and adheres to ASME-BPE guidelines. Its control system seamlessly integrates with existing production lines, offering automatic control that aligns with GAMP5 and FDA 21 CFR Part 11 standards, ensuring strict compliance and traceability.

Engineered for flexibility, the chromatography system allows for customization of fillers and operation modes, including batch processes. It enhances solvent efficiency and reduces energy consumption, tailored for scalable production needs ranging from research laboratories to full-scale pharmaceutical manufacturing.

Included is a robust quality management system and comprehensive validation services, ensuring reliable operation and minimal downtime. AUSTAR provides extensive engineering support to tailor systems specifically for customer requirements, delivering documentation and technical support to facilitate implementation and ongoing operations.

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Integrates Upstream and Downstream Bioprocess Operations

The Bioprocess System from AUSTAR is engineered to support the demanding needs of biopharmaceutical companies and research institutions. This system excels in integrating upstream and downstream operations, employing cutting-edge stainless steel and single-use technologies to handle processes such as fermentation, chromatography, and virus removal efficiently. Designed to produce monoclonal antibodies, vaccines, and gene therapy vectors, it facilitates scalable production from pilot to commercial levels. The system can process various forms, maintaining product integrity while ensuring compliance with ISO9001 and ASME-BPE standards. With automation capabilities that include PLC controls and remote monitoring, it ensures seamless integration into production lines. The equipment’s energy efficiency is optimized through advanced motor controls, aligning with stringent sustainability objectives. It is available with customizable options for materials and configurations, backed by comprehensive engineering support for tailored production solutions.

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Integrates Upstream and Downstream Bioprocessing

The Hybrid Bioprocess System from AUSTAR seamlessly integrates stainless steel and single-use technologies to enhance both upstream and downstream bioprocessing. This flexible system is tailored for pharmaceutical, biopharmaceutical, and biotechnology firms, offering comprehensive solutions for processes such as media preparation, cell culture, and purification of biologics including monoclonal antibodies, vaccines, and insulin. With customizable configurations, this system supports automatic control and validation, ensuring optimized throughput and precision. Its hybrid design leverages the robustness of stainless steel and the adaptability of single-use components, providing cost-effective and scalable solutions. The system is compatible with cGMP standards and supports clean-in-place (CIP) protocols, minimizing maintenance downtime while maintaining strict sterility. Available engineering support and project management services ensure seamless integration into existing production lines, addressing diverse operational needs with precision and reliability.

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Continuously Separates and Purifies Complex Liquid Mixtures

The Sequential Simulated Moving Bed (SSMB) System from Applexion is an industrial chromatography solution designed for the continuous separation and purification of complex liquid mixtures. This system stands out for its ability to achieve high purity and recovery rates, up to 99%, while minimizing resin and footprint requirements. It employs a multi-column setup that facilitates efficient 24/7/365 operations, crucial for industries requiring high throughput, such as food ingredients and pharmaceuticals.

Ideal for producing high-fructose corn syrup, crystalline fructose, and various amino and organic acids, the SSMB technology is particularly suited for bio-based and fermentation-based products. By leveraging advanced PLC automation, the system ensures seamless integration into existing production lines and offers remote monitoring capabilities. Energy efficiency is enhanced through optimized flow distribution, significantly reducing operational costs.

Constructed from materials like stainless steel to withstand corrosion and chemical reactions, it meets industry standards for safety and compliance. The design includes options for CIP (Clean-In-Place) systems, simplifying maintenance, and reducing downtime. Applexion provides extensive customization and engineering support, tailoring configurations to meet specific production needs, ensuring that each setup is optimized for the highest performance and efficiency.

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Enhances Distillation and Fermentation Efficiency

The versatile Mobile Pilot Distillation and Fermentation Systems from GEA are designed to optimize separation and purification processes across a range of industries, including pharmaceuticals, food, and energy. Featuring state-of-the-art pilot plants, these systems can be configured for both stationary and mobile operations, with remote control capabilities enhancing operational flexibility. Designed to handle diverse product types—liquid, gas, and slurry—these systems apply distillation, fermentation, and evaporation techniques to efficiently produce high-quality outputs such as ethanol, essential oils, and bioplastics.

Equipped with glass and stainless steel distillation columns, the systems utilize random packing, sieve trays, and Thormann trays, allowing precise observation and treatment of various substances, including higher-viscosity products. With the capability to function under continuous, batch, and remote operations, they support R&D and laboratory environments effectively.

Energy efficiency is realized through options for direct steam or thermal oil heating, integrating seamlessly with production lines for minimal operational costs. Ensuring compliance with industry standards, these units offer comprehensive customization and engineering support to meet specific throughput and processing needs, backed by GEA’s commitment to durable construction and enhanced process control.

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