Laboratory mixer mill for small volume grinding
Designed for rapid homogenization and size reduction, this versatile mixer mill efficiently processes small volume samples, ensuring consistent results across biological, chemical, and geological applications. Ideal for labs needing precise control over mixing parameters for optimal extraction and analysis outcomes.

Mixes, Homogenizes, and Reduces Sample Size
The Mixer Mill MM 400 by Retsch is an advanced laboratory device engineered for efficient sample preparation and homogenization across multiple industries. Utilizing radial oscillations and high-energy impacts, it effectively mixes, homogenizes, and reduces sample sizes, making it ideal for applications such as DNA/RNA extraction, isotopic sample preparation, and cryogenic grinding. With a frequency range up to 30 Hz, the MM 400 handles a variety of materials, including biological samples, pharmaceuticals, and geological materials. It supports two grinding stations, caters to bench-top operations, and can accommodate capacities of up to 2 x 20 ml. The digital control system and programmable SOPs ensure precise and reproducible results. Designed for the R&D and laboratory departments, it is essential for pharmaceutical laboratories, research institutions, and environmental testing labs. Available in materials like stainless steel and zirconium oxide, it ensures contamination-free preparations, adhering to rigorous industry standards. Its compatibility with various jar materials and optional accessories further enhances its versatility and customization potential.
Benefits
- Enhances research efficiency with rapid sample preparation and homogenization.
- Supports versatile applications, accommodating both biological and mechanical samples.
- Ensures reproducible results with programmable SOPs and precise digital controls.
- Minimizes contamination risk with a range of material options such as zirconium oxide.
- Enables diverse processing needs, including cryogenic grinding and cell disruption, suitable for laboratory and pharmaceutical applications.
- Applications
- Chemicals,Construction materials,Minerals,Metals,Waste samples,Agricultural products,Environmental samples,Glass/ceramics,Plant materials,Food products,Geological materials,Textiles,Biological samples,Pharmaceuticals
- End products
- Hard mineral pulverizations,Protein extracts,Waste biomass homogenizations,Isotopic analysis sample preparations,Recycled material pellets,Geological powder samples,Ceramic powder mixtures,Herbal extract suspensions,Pesticide-treated plant extracts,Homogenized construction material samples,Textile fiber samples,Dna/rna pellets,Cannabis extracts,Soil sample suspensions,Homogenized tissue for research
- Steps before
- Sample Collection,Pre-cooling,Homogenization,Cell Disruption Preparation
- Steps after
- Sample Analysis,Isotope Analysis,Pesticide Extraction,Protein Extraction
- Input ingredients
- alloys,animal feed,bones,ceramics,cereals,chemical products,coal,coke,drugs,electronic scrap,glass,grains,hair,minerals,oil seeds,ores,paper,plant materials,plastics,sewage sludge,soils,straw,tablets,textiles,tissue,tobacco,waste samples,wood,wool,microalgae,capsules with liquid,polyurethane pellets,concrete
- Output ingredients
- homogenized powders,suspensions,grinded mixtures,cryogenically processed samples,homogenized biological samples,cell disrupted suspensions,DNA/RNA extraction,protein extraction,herbal ingredient extraction,QuEChERS extracted pesticides,pellets for XRF,in-situ RAMAN spectroscopy ready samples,fine powders,mechanochemically altered substances
- Market info
- RETSCH is known for its high-quality laboratory equipment for sample preparation and particle size analysis, including mills, crushers, and sieve shakers, praised for their precision, durability, and reliability in research and industrial applications.
- Max Speed
- 30 Hz
- Feed Size
- Up to 8 mm
- Final Fineness
- ~ 5 µm
- Batch Size / Feed Quantity
- Max 2 x 20 ml
- Vibrational Frequency
- 3 - 30 Hz (180 - 1800 min-1)
- Mean Grinding Time
- 30 s - 2 min
- Max Grinding Time
- 99 h
- Dry Grinding
- Yes
- Wet Grinding
- Yes
- Cryogenic Grinding
- Yes
- Cell Disruption with Reaction Vials
- Yes,up to 20 x 2.0 ml
- Grinding Jar Sizes
- 1.5 ml / 5 ml / 10 ml / 25 ml / 35 ml / 50 ml
- Setting of Grinding Time
- Digital,10 s - 8 h
- Storable SOPs
- 12
- Storable Cycle Programs
- 6
- Power Consumption
- 165 W
- Net Weight
- ~ 27.5 kg
- Automation level
- Manual / PLC / SCADA
- Batch vs. continuous operation
- Batch
- Cleaning method
- Manual / Pre-cooling in liquid nitrogen
- Energy efficiency
- Low kWh/kg
- Biological compatibility
- DNA/RNA
- Abrasion resistance
- Steel,zirconium oxide
- Cleanability
- Stainless steel jars
- Corrosive resistance (e.g. acids)
- Zirconium oxide
- Density/particle size
- glass beads
- Cell disruption
- DNA/RNA,Protein extraction
- CE marking
- Yes
- ISO/IEC 17025
- Applicable
- ISO 9000ff
- Applicable
- Compact footprint
- 385 x 350 x 470 mm
- Net Weight
- ~ 27.5 kg
- Max Feed Size
- 8 mm
- Grinding Jar Sizes
- 1.5 ml / 5 ml / 10 ml / 25 ml / 35 ml / 50 ml
- Grinding Stations
- 2
- Clamping Device
- Self-centering
- Type of Grinding Jars
- Screw top design
- Control panel type
- Touch display
- Jar materials
- Hardened steel,stainless steel,agate,tungsten carbide,zirconium oxide,PTFE,PMMA
- Grinding modes
- Dry,wet,cryogenic
- Sample adapters
- Adapters for single-use vials,conical centrifuge tubes
- Grinding stations
- 2 grinding stations
- Programmable settings
- Storable SOPs and cycle programs
- Size range for grinding balls
- 5 mm to 25 mm
- Cryogenic processing options
- Pre-cooling in liquid nitrogen,CryoKit available
- Frequency calibration
- Calibrated speed and time
- Noise reduction features
- Significant noise reduction
- Sample throughput enhancement
- Multiple adapters for increased sample throughput