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When working with Cell and Gene therapies, precise and sterile filling processes are critical. Challenges often include maintaining aseptic conditions, minimizing cell stress, and controlling fill volumes to ensure product integrity.
<h2>Facilitates aseptic filling of cell and gene therapy products</h2>
The ValueCell FILL by Comecer is a semi-automatic filling system specifically designed for the Cell and Gene therapy fields. This system supports downstream aseptic bag filling operations, offering a closed and modular solution. It includes a refrigerated storage area, a distribution rack, and a peristaltic pump filling system, ensuring low shear stress for sensitive products. The ValueCell FILL is compatible with Grade C cleanroom environments, and its reverse pumping feature minimizes product loss. It is equipped with gentle paddle mixers for ensuring a homogeneous mixture and in-line bubble sensors for quality control. The system handles fill volumes ranging from 50 to 250 mL, with a capacity of up to 150 bags per hour. Ideal for dispensing viral vectors, final cell products, intermediates, and media, it also offers scalable batch sizes to match production growth and includes an intuitive touchscreen HMI for easy operation.

Semi-automatic filling system for cell and gene therapy

Control

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

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Semi-automatic filling system for cell and gene therapy

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