Ensures Safe Handling and Containment

The Containment System / Glove Box from HEINKEL Drying & Separation Group is designed to enhance safety and efficiency in handling sensitive materials during batch processing. This system effectively isolates operations such as sampling, discharging, and packaging, ensuring both operator safety and product integrity. It is particularly suited for pharmaceutical and chemical industries producing active pharmaceutical ingredients, specialty chemicals, and catalysts.

The glove box operates by creating a sealed environment, preventing contamination with its flange-connected isolator, ideal for integration with Nutsche filter dryers. While handling solids, powders, and cakes, it allows full product yield by facilitating the discharge of residual heel and safe disposal of filter cloths.

For those prioritizing operational efficiency, this system seamlessly integrates into your production line with manual batch operations. The containment system is manufactured with corrosion-resistant materials, offering customization options to meet specific industry compliance standards such as GMP and FDA. Designed for reliability and ease of maintenance, it supports safe disposal processes and complete protection of both product and staff within pharmaceutical, chemical, and metal recycling applications.

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Filters, Dries, and Separates Solid and Slurry Products

The Pressofiltro® Series PF 2000 – PF 16000 from COMBER is a versatile filter dryer designed for pharmaceutical, chemical, and food product manufacturers. This equipment combines filtration and drying processes within a closed unit, optimizing production efficiency and reducing contamination risks. Its unique agitator blade design ensures effective and even product movement during the drying process, while the narrow agitator-to-wall clearances enhance emptying characteristics. Suitable for both batch and continuous operations, it handles solid, powder, slurry, and cake products, making it ideal for producing APIs, chemical intermediates, or powdered metals. With a control cabinet featuring PLC and HMI, it supports seamless integration with existing production lines. Constructed from materials like stainless steel and Hastelloy, it offers excellent corrosion resistance for handling aggressive substances. Certified for operation under the EU-Type Examination Certificate and capable of UL-approved installations, it meets high safety standards. The inclusion of a CIP system ensures thorough, contamination-free cleaning, making maintenance efficient while minimizing downtime.

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Filters, Dries, and Contains Hazardous Materials

The COMBER Pressofiltro® Series PF 50 – PF 2000 is an engineered solution from HEINKEL Group designed to meet rigorous industrial requirements for filtration and drying. Unique in its integration of an agitated Nutsche filter with a containment system, it addresses the high-stakes challenge of handling hazardous materials safely. Utilizing containment glove boxes, it ensures contamination-free product handling, crucial for maintaining purity in pharmaceutical ingredients and specialty chemicals.

The system supports operations such as batch or continuous processing for a variety of materials, including slurries and cakes. It features variable design capacities from 0.13 to 2 m² filter area and slurry volumes ranging from 55 to 2,000 liters. Engineered to adhere to cGMP and FDA guidelines, it employs HEPA-filtered air handling to maintain containment levels down to 10 ng/m³ TWA.

Constructed with high-grade materials like stainless steel and Hastelloy, it offers exceptional resistance to corrosive substances. The system’s automated features include a PLC-controlled interface, enabling seamless integration with existing production lines. Enhanced by options like dust filters, CIP systems, and vacuum units, the COMBER Pressofiltro® ensures both efficiency and safety in demanding applications.

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Performs Filtration, Drying, and Inspection

The COMBER Pressofiltro® Series PF 100 – PF 10000 is designed for multipurpose production facilities in pharmaceutical and chemical industries. Featuring a robust agitation mechanism for efficient slurry processing, it caters to the filtration and drying needs of APIs, specialty chemicals, and nutraceutical powders, ensuring precise moisture control. With a modular design, it accommodates a range of slurry volumes from 100 to 10,000 liters, offering seamless integration into both batch and continuous operations. Constructed with high-grade stainless steel and options for nickel-based alloys, it guarantees corrosion resistance, aligning with stringent cGMP and FDA standards. The system incorporates automated CIP processes for superior cleanability, minimizing contamination risk and downtime. The PLC-controlled unit is equipped with HMI touchscreens for intuitive operation and can integrate with DCS for enhanced process management.

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Filters and Separates Slurries and Cakes Efficiently

The Multilayer Filter Plate from the HEINKEL Drying & Separation Group is an essential component for Nutsche Filter Dryers, tailored to meet the diverse demands of pharmaceutical, chemical, and food industries. These plates excel in providing precise filtration and separation, utilizing a customizable multi-layer design that supports efficient batch processing of slurries, cakes, and liquids. With applications extending to the production of active pharmaceutical ingredients (APIs), specialty chemicals, and food additives, they ensure reliable performance and longevity.

The plates are offered in a range of materials, including SS 316L and Hastelloy C22, to withstand corrosive environments and backpressure of up to 0.5 bar. Their smooth surfaces and underside mounting facilitate easy cleaning and maintenance, making them ideal for pharmaceutical uses requiring stringent hygiene standards. These plates seamlessly replace existing components, even across different machine brands, and can be divided into sectors, allowing cost-effective maintenance in case of wear or breakage. Their robust design enables the efficient integration into existing lines, ensuring continuous operation and process optimization.

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Filters, Dries, and Mixes Pilot-Scale Products

The COMBER Pressofiltro® / Turbodry® Series PF/TD units by Heinkel are versatile pilot plant filter and vacuum dryers designed for industries such as pharmaceutical, chemical, and food processing. Specially engineered to perform processes like filtration, drying, and mixing, they cater to operations that require small-scale production or pilot testing. This equipment is ideal for end-products like active pharmaceutical ingredients, epoxy resin powder coatings, and synthetic pigments.

Constructed in accordance with the Pressure Equipment Directive 97/23/EG and ASME U-stamp, these units are compliant with GMP and FDA guidelines, ensuring certification for pharmaceutical applications. They operate safely in ATEX danger zones (group II 2G 2D, zones 1/21) thanks to their explosion-protected control system (EEx-d). Built on a skid with a secure shaft seal via a gland nut, they support easy integration within existing production lines.

Customization is available, featuring a multilayer PLC system to enhance automation and process control. This series caters to Research & Development, laboratory, and processing departments seeking efficient filtration and drying of slurry and cake types. The equipment is also engineered for ease of maintenance with its robust design and materials suitable for a range of industrial environments.

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Filters and Dries Slurries in Pilot Batches

The COMBER Pressofiltro® Series PF 5 – PF 100 Pilot Plant units from the HEINKEL Group are designed for precise filtration and drying in pilot and laboratory settings. Engineered to cGMP and FDA guidelines, these units provide versatile processing for pharmaceuticals, chemicals, and food products, converting slurries into dried solids like active pharmaceutical ingredients and specialty chemicals. Each unit employs an efficient filter dryer mechanism, housed in compact skid-mounted systems for easy integration into R&D labs or small-batch production lines.

These pilot units support capacities from 8 to 100 liters and feature interchangeable vessel bases for conversion to conical bottom or Nutsche dryers, enhancing flexibility across applications. The equipment’s heated, stainless steel or Hastelloy contact surfaces ensure uniform drying while resisting corrosion. A PLC-controlled system facilitates automation and seamless integration into existing setups. Customizable options include steam sterilizable and aseptic designs, dust filters, sampling valves, and CIP systems, all of which simplify maintenance and enhance safety and cleanability, making them ideal for moisture-sensitive processes.

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Filters, Dries, and Mixes Chemical and Pharmaceutical Products

The Lab Fast Pro Nutsche Filter from NORMAG is an adaptable bench-top solution designed for chemical and pharmaceutical processing. It features a universal support frame capable of handling vessels from 100ml to 10 liters, facilitating swift swaps of glassware to minimize downtime. Its full-jacketed design ensures efficient heating and cooling, essential in processes involving temperature-sensitive reactions. The filter accommodates a wide range of applications, such as the production of active pharmaceutical ingredients, vitamin C supplements, and essential oil extracts, through its versatile filtration, drying, and mixing capabilities.

The Lab Fast Pro operates manually and supports pilot operations, making it ideal for laboratory and research environments. Its unique tool-free clamping mechanism, chemical resistance with glass and PTFE components, and integrated tilting mechanism for effortless product discharge underscore its engineering quality. With options for additional modules like distillation and liquid dosing, and a unique stirrer guide preventing PTFE flaking while maintaining chemical resistance, the system promises precise control over the production process. Customizable features and engineering support enhance its integration into existing setups, ensuring that it meets specific processing needs.

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Cultivates High-Yield Cell Cultures

The Bioreactor – Fermentor System from De Dietrich Process Systems is engineered for cultivating high-purity biopharmaceutical products. With a borosilicate 3.3 glass construction according to EN1595 standards, its design includes a monobloc inner vessel with a surface finish of ≤ Ra 0.02 μm for optimal cleanliness. Capable of precise agitation and aeration, this system is essential for producing monoclonal antibodies, synthetic peptides, and more. Ideal for operations in R&D labs, biotechnology, and specialty chemicals, it integrates seamlessly into existing processes with various control options, including 21 CFR part 11 interface. The equipment is customizable, offering mechanical or magnetically coupled agitation and stainless steel or alloy components, ensuring compatibility and corrosion resistance. It maintains GMP compliance with complete QA/QC plans, and includes CIP systems for efficient cleaning, making it an indispensable tool for high-stakes production environments.

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Performs Homogenization, Emulsion, and Deaeration

The BACHLAB Laboratory Vacuum Mixer Reactor from Bachiller is designed for precise laboratory-scale processing of liquids and semi-solids, making it essential for industries like pharmaceuticals and cosmetics. Featuring a coaxial stirring assembly and high shear rotor-stator system, it excels in homogenization, emulsion, and deaeration tasks. Suitable for creating end-products like face serums and epoxy adhesives, it offers capacities from 5 to 150 liters. Automation is ensured through a PLC control system with Ethernet connectivity for easy supervision and recipe management. Engineered for integration, it operates under vacuum or pressure conditions with heating and cooling options. Its sanitary design complies with cGMP and EHEDG standards, ensuring ease of cleaning and maintenance. Options include ATEX certification and compatibility for FDA validation, highlighting its adaptability to unique production requirements.

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