Microbial bioreactors - Making.com

Single-use bioreactors for microbial fermentation

admin — Fri, 20 Sep 2024 10:51:32 +0000

Optimize high-density fermentation with advanced single-use bioreactor technology, ensuring efficient mixing and mass transfer for robust microbial applications while minimizing contamination risks.

Facilitates Scalable Microbial Fermentation Processes

The BioBLU®f Single-Use Bioreactors from Eppendorf are specially designed for microbial applications, offering a rigid-walled stirred-tank format ideal for high-cell density fermentation. These bioreactors mimic traditional designs, ensuring effective mixing and mass transfer. They are suitable for producing monoclonal antibodies, insulin, and biofuels, with a working volume range of 65 mL to 3.75 L. Optimized for processes such as fermentation and cultivation, they integrate seamlessly with Eppendorf’s bioprocess controllers and selected third-party systems. With fully enclosed bearings and a sealed magnetic drive, they maintain sterility, while interior baffles and Rushton-type impellers ensure efficient mixing. Available in presterilized, autoclavable configurations, they support high agitation speeds and effective cooling, addressing the complex needs of the pharmaceutical, biotech, and biofuel industries while minimizing process risks.

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Tangential flow filtration system for cell harvesting

admin — Tue, 03 Sep 2024 15:24:23 +0000

Optimize your biopharmaceutical production by integrating a versatile filtration system that ensures efficient separation and purification, crucial for maintaining high product quality in sensitive processes like gene therapy and monoclonal antibody production.

Filters and Purifies Biopharmaceutical Products

Sartorius offers a comprehensive range of process filtration systems tailored for the biopharmaceutical industry, renowned for their reliability and precision. Utilizing cutting-edge membrane technology, these systems effectively filter and purify liquids, crucial for applications in producing monoclonal antibodies, vaccines, and gene therapies. Featuring scalable and customizable solutions, Sartorius designs these units to handle various capacities, ensuring seamless integration with existing production lines. Their systems are equipped with advanced PLC controls for automation and monitoring, optimizing energy use and ensuring adherence to stringent GMP and FDA standards. Constructed from high-grade materials, these filtration units offer exceptional resistance to corrosion, making them ideal for challenging pharmaceutical environments. Furthermore, these systems are designed with CIP capabilities to facilitate maintenance and maximize operational efficiency. Sartorius extends comprehensive engineering support and customization options to meet specific processing requirements, ensuring your system aligns perfectly with your production goals.

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Surface plasmon resonance maintenance services

admin — Tue, 03 Sep 2024 15:24:23 +0000

Maximize the lifecycle and performance of your surface plasmon resonance systems with comprehensive maintenance and optimization solutions, ensuring precise molecular interaction analysis and reducing downtime for efficient biopharmaceutical development.

Analyzes and Detects Biomolecular Interactions

The Octet® SF3 Surface Plasmon Resonance System from Sartorius is expertly designed to facilitate precise biomolecular interaction analysis, essential for pharmaceutical and biotech labs aiming to streamline drug discovery and biologics development. Utilizing OneStep® Injection Technology, it permits high-throughput kinetic and affinity measurements from a single analyte concentration, significantly reducing reagent use. This system supports a wide array of applications, including monoclonal antibody therapeutics, mRNA vaccines, and regenerative medical treatments. With the capability to manage up to 768 samples in unattended assays, the Octet® SF3 enhances research efficiency. Its integration into existing lab setups is seamless, offering automated, PLC-controlled operation with remote monitoring options. The system ensures compliance with industry standards and comes with comprehensive service and maintenance plans to ensure consistent performance. Additionally, it offers customization options to suit specific research needs, reinforced by Sartorius’ engineering support.

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Single-use batch chromatography systems for biopharmaceuticals

admin — Tue, 03 Sep 2024 15:24:23 +0000

Streamline your purification process with high productivity and reduced resin costs, enabling efficient downstream operations for complex biomolecules.

Purifies Biomolecules and Accelerates Chromatography Processes

Sartorius’ Sartobind® Rapid A, part of its esteemed chromatography portfolio, is specialized for swift and efficient biomolecule purification. This membrane system excel in high-throughput applications, leveraging rapid cycling to achieve up to 14x productivity increase during capture stages, beneficial for monoclonal antibodies and vaccine manufacturing. It eliminates the need for column packing, reducing operational time and freeing up your resources. Designed for column-free operation, it requires no additional setup, ensuring immediate deployment within your production line. Capable of integrating with existing systems, it supports batch and continuous operations, ideal for pharmaceutical and biotechnology environments. The Sartobind® Rapid A offers substantial cost savings by minimizing resin volumes used, contributing to reduced operational costs and increased process efficiency. Every unit is constructed to uphold compliance with GMP standards, facilitating seamless production while ensuring safety and reliability. With membrane chromatography’s inherent energy efficiency, anticipate a reduction in energy consumption throughout your bioprocessing activities.

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Multi-parallel bioreactors for cell line selection and process development

admin — Tue, 03 Sep 2024 15:24:04 +0000

Enhance your biopharmaceutical production with scalable multi-parallel bioreactors, enabling rapid cell line selection and process optimization, while minimizing time and resources in your development workflow.

Facilitates Clone Screening and Process Optimization

The Ambr® series from Sartorius offers state-of-the-art multi-parallel bioreactor systems like the Ambr® 15 Cell Culture and Ambr® 250 variants, which are engineered to enhance biopharmaceutical production processes. These systems excel in rapid clone screening and process optimization through automated liquid handling and data integration, making them invaluable for biopharmaceutical, cell and gene therapy, and monoclonal antibody production. Designed to handle small-scale, high-throughput operations effectively, these bioreactors support a range of cell cultures, including mammalian and microbial, with customizable vessel configurations. The single-use design optimizes cleaning and maintenance, while built-in data analytics tools facilitate process scaling and integration into existing production workflows. Compliant with industry standards, these systems are suitable for environments demanding stringent process control and efficiency.

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Single-use fermenter for microbial applications

admin — Tue, 03 Sep 2024 15:24:04 +0000

Optimize biopharmaceutical production with a single-use fermenter engineered for efficient fermentation and high-growth microbial cultivation, enabling quick process transfer and enhanced automation in your operations.

Facilitates High-Density Microbial Fermentation

The Biostat STR® Microbial from Sartorius is a versatile single-use fermenter engineered for high-density microbial cultivation, particularly in biopharmaceutical applications such as pharmaceuticals, vaccines, and recombinant proteins. It combines the advantages of single-use technology with the robust performance of stainless-steel systems. The system leverages the Biobrain® automation platform, offering precise control over cultivation parameters for seamless process integration and scalability. Supporting working volumes up to 40 liters, it’s ideal for producing monoclonal antibodies, mRNA vaccines, and plasmid DNA. The Biostat STR® Microbial’s modular design allows easy process transfer, reducing operator risk and contamination through its single-use Flexsafe® STR bags. This system meets GMP standards, ensuring compliance and facilitating efficient waste disposal and maintenance with faster batch turnover due to minimized cleaning protocols. Customize and integrate effortlessly into existing operations with support for either cell culture or microbial processes, enhancing productivity and throughput in your production line.

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Single-use bioreactors for mammalian cell culture

admin — Tue, 03 Sep 2024 15:24:04 +0000

Enhance agility and cut costs with scalable, single-use bioreactors ideal for streamlining the transition from lab-scale cell cultures to full-scale biomanufacturing, ensuring consistent and efficient production cycles.

Facilitates Scalable Biopharmaceutical Production

The Ambr® 15 and Ambr® 250 series from Sartorius are single-use bioreactor systems designed for streamlined biopharmaceutical production. These systems uniquely enhance scalability and adaptability in processes such as monoclonal antibody and mRNA-based vaccine manufacturing. Utilizing a modular design, they allow for seamless integration into batch or continuous operations, supported by advanced process automation and monitoring capabilities. The Ambr® systems accommodate varying scales from pilot to commercial production, ensuring flexibility without compromising on precision control over cell culture conditions. With their disposable bag technology, they eliminate the need for cleaning and sterilization, reducing turn-around times and increasing operational efficiency. Known for superior performance in high cell-density and sensitive cell lines, the systems feature Flexsafe® film, contributing to consistent growth and viability. The equipment is engineered for compliance with GMP standards, while offering customization options to meet specific production requirements, supported by Sartorius’ extensive engineering and technical support network.

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Precision weighing cells for laboratory use

admin — Tue, 03 Sep 2024 15:23:47 +0000

Ensure precise measurements and enhance reliability in laboratory processes with top-performing weighing cells, vital for maintaining the integrity of sensitive and high-value biopharmaceutical products.

Delivers Precision Weighing for Lab and Industrial Needs

The Precision Weighing Cells from Sartorius are essential components for lab weighing and industrial applications, capable of handling up to 8.2 kg with a resolution as fine as 0.001 g. These weighing cells are machine-crafted from a solid aluminum block, eliminating the impact of temperature and mechanical influences for enhanced performance reliability. Ideal for biopharmaceuticals, diagnostics, and lab environments, they ensure accurate measurements crucial for producing monoclonal antibodies, mRNA vaccines, and CAR-T cell therapies. Integration into laboratory or production lines is seamless, offering both manual and semi-automated operations. Sartorius’s Precision Weighing Cells provide consistent performance, with optional engineering support for tailored solutions. Compliance with industry standards ensures suitability for pharmaceutical and biotechnological processes, with user-friendly calibration and maintenance protocols to maintain uninterrupted operations.

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Explosion proof weighing cells for hazardous environments

admin — Tue, 03 Sep 2024 15:23:29 +0000

Designed for hazardous environments, these weighing cells ensure precise measurements and safety, adhering to stringent explosion-proof standards, making them essential for critical processes in chemical and pharmaceutical applications.

Weighs Explosive and Volatile Substances Safely

The WZA6202-NX and WZA623-NX explosion-proof weighing cells from Sartorius are engineered to meet the rigorous demands of hazardous industrial environments, providing precise and safe weighing solutions for volatile substances. Built to comply with ATEX, IECEx, and FM Approvals for Class I, II, and III, Division 1 environments, these cells feature specially protected electronics to ensure operational integrity amidst explosive atmospheres. Ideal for pharmaceutical, chemical, and petrochemical industries, they integrate seamlessly into laboratory and industrial processes, weighing materials such as ammonium nitrate, TNT, and specialty chemicals with 1 mg accuracy. With robust corrosion-resistant construction and available in stainless steel, they offer reliable performance in challenging conditions. The weighing cells are accompanied by all necessary cabling for easy installation and comply with stringent safety standards, making them an integral part of modern hazardous environment monitoring and weighing systems.

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