Prepares and Doses Media and Buffers

The Media / Buffer Prep system from Bioengineering is essential for biopharmaceutical and pharmaceutical production lines, optimizing the preparation and dosing of media and buffers. Featuring sterilizable stainless-steel vessels ranging from 30 to 20,000 liters, it ensures sterile, dust-free transfer and dissolution of powders using the Cup-Hermann system. This equipment is tailored for operations from manual to full automation, integrating seamlessly with upstream and downstream processes in labs, R&D facilities, and production plants. It supports applications including recombinant protein production, monoclonal antibodies, and vaccine formulations. The system is PLC-controlled, enabling precise level, weight, and pH control, and integrates with CIP systems for efficient cleaning. Built to meet GMP standards, it offers customizable configurations to match unique process requirements, promising reliability and high product quality.

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Cultivates and Processes Cell Cultures Efficiently

Bioengineering AG offers custom bioreactor systems designed for precision in cell cultivation. These bioreactors use innovative aeration strategies and wide impellers to accommodate shear-sensitive cells in applications ranging from monoclonal antibody production to skincare serum formulation. Capacities range from 30 to 25,000 liters, supporting continuous production with integrated perfusion systems. The BioSCADA software allows seamless automation and monitoring, enhancing efficiency with energy-saving temperature control and gas-mixing stations. Available in stainless steel, these systems comply with cGMP standards, ensuring compatibility and corrosion resistance. For flexible operation, optional CIP systems enable efficient cleaning, minimizing downtime, while comprehensive engineering support is available for tailored configurations.

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Automates and Optimizes Cleaning Processes

The CIP-Mobile Cleaning System from Bioengineering AG is engineered to streamline and enhance sanitation processes across various industries, including biopharmaceuticals, food, and cosmetics. This system excels in its ability to automatically clean complex equipment like fermentors and bioreactors through a meticulously controlled sequence involving pre-rinsing, alkaline cleaning, and final rinsing. Designed with flexibility in mind, it includes up to 28 programmable cleaning steps and is equipped with dual 200-liter tanks, a circulation pump, heat exchangers, and robust parameters control such as temperature and flow rates. Ideal for tackling challenges in operations ranging from pilot to large-scale production, this solution ensures surfaces in contact with products remain free of contaminants to avert cross-contamination. Constructed with high-grade materials, it supports recycling of cleaning solutions where applicable, promoting both economic and ecological benefits. The CIP-Mobile is compatible with industrial standards, featuring seamless integration with existing production lines through its PLC-controlled system, offering reliable documentation and control adjustments to meet stringent hygiene requirements.

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Cultivates Microorganisms and Optimizes Fermentation Conditions

The stainless steel fermentor from Bioengineering is engineered to streamline microbial cultivation for the biopharmaceutical and nutraceutical industries. This equipment leverages advanced aeration strategies and precise control over oxygen supply, dosage, and temperature, ensuring optimal fermentation conditions for producing insulin, vaccines, and monoclonal antibodies. With capacities ranging from 30 to 50,000 liters, the fermentor accommodates both pilot and full-scale production. Designed for seamless integration into existing production lines, it features a PLC-controlled system for automated operations and offers compatibility with various control software, including BioSCADA, for intuitive management. Compliant with GMP standards, the fermentor includes integrated CIP systems for efficient cleaning and maintenance. Additionally, Bioengineering provides customization options to suit specific production needs, backed by over 50 years of industry expertise.

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Mixes, Doses, and Homogenizes Liquid Formulations

Bioengineering’s stainless steel formulation vessels are designed for precision and reliability in biopharmaceutical production environments. These vessels ensure consistent mixing, dosing, and homogenizing of liquid formulations, crucial for the production of monoclonal antibodies, mRNA vaccines, and other high-value pharmaceuticals. Engineered for both manual and fully automated operations, they feature magnetic stirrers and optional vibromixers, which maintain homogeneity at various volume levels, even with complex suspensions. With capacities ranging from 50 to 2,500 liters, these vessels can handle a wide range of production scales. Each unit ensures meticulous control over temperature and pH, with integrated cooling and dosage systems to maintain product integrity from start to transfer. Standards-compliant and equipped with an isolated loop system for seamless integration into filling lines, the vessels offer comprehensive solutions for efficiency and adaptability in modern pharmaceutical processes. Designed for use in strict hygienic conditions, they meet cGMP and other global quality standards, ensuring compliance and reliability across applications.

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Deactivates and Sterilizes Contaminated Wastewater

The Killtank Wastewater Decontamination System, offered by Bioengineering AG, is designed to address the critical production need for the deactivation of pathogenic and genetically modified organisms in wastewater. This system employs a combination of batch or continuous heat sterilization processes to ensure thorough decontamination, adhering to local regulatory standards.

Ideal for biopharmaceutical manufacturers, research labs, and wastewater treatment facilities, the Killtank system plays a vital role in producing sterile effluents and safeguarding the environment. It features automated controls for both batch and continuous modes, integrating seamlessly into existing processes with options for manual operation where needed.

The system incorporates heat exchangers capable of pre-heating wastewater to 100°C and then elevating temperatures to 140°C for complete inactivation, followed by rapid cooling. Additionally, energy efficiency is enhanced through a built-in heat recovery system.

Constructed from materials that offer superior corrosion resistance, the Killtank is compliant with stringent safety and environmental standards, making it a reliable choice for managing biohazardous waste. Maintenance is simplified with an integrated Cleaning In Place (CIP) system, facilitating quick, contamination-free cleaning and ensuring minimal downtime.

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