Processes and Refines Microspheres for Drug Delivery Systems

The MSR™ MicroSphere Refiner by Powder Systems Limited (PSL) is a comprehensive solution for pharmaceutical and biotechnology manufacturers focused on drug delivery via microspheres. This fully automated system integrates multiple stages of processing, including classification, filtration, de-watering, washing, drying, freeze-drying, sampling, and recovery. Designed for aseptic, batch operations, it addresses the challenge of handling valuable microspheric products by maximizing product recovery and maintaining batch consistency.

Featuring capabilities for both liquid and solid product types, the MSR™ accommodates various vessel sizes, with options supporting product cake volumes from 1.25 to 21.8 liters. The flexible design of the MSR™ supports multi-product applications, making it adaptable to rapidly changing production requirements. Enhanced process control is ensured through the integration of Process Analytical Technology (PAT), allowing for real-time quality monitoring and adherence to Good Manufacturing Practices (GMP), GAMP5, and 21 CFR Part 11 regulations.

The unit’s modular design supports seamless integration into existing pharmaceutical production lines, with vessel materials ensuring chemical compatibility and corrosion resistance. Maintenance is simplified via a Clean-In-Place (CIP) option, promoting contamination-free operations. The MSR™ is engineered for scalability, enabling a smooth transition from R&D to commercial production, ensuring critical process parameters are maintained throughout scale-up.

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Processes and Mixes Solids, Liquids, and Slurries

The Continuous Vacuum Cooking and Mixing System from ProXES excels in precise thermal processing for a range of applications. Ideal for food and pharma industries, it ensures consistent production of high-quality end products like caramel candy fillings, hummus, and pharmaceutical ointments. This system utilizes advanced vacuum cooking for energy-efficient heating and mixing, providing controlled environments to enhance texture and flavor. Capable of processing up to several thousand kilograms per hour, it offers seamless integration with existing lines through PLC-controlled automation and remote monitoring. Made from corrosion-resistant materials, it complies with industry standards for food safety and pharmaceutical manufacturing. The system supports clean-in-place (CIP) processes for efficient and hygienic maintenance, with customizable features to meet specific production needs.

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Processes, Cooks, and Heats Diverse Products

ProXES offers the COOK-IT® and SAM® series, engineered for diverse industrial applications, providing precise cooking and heating solutions. These systems are tailored with innovative heating technologies like direct steam injection and indirect cooling for batch and continuous processing. Suitable for producing a wide range of food, pharmaceutical, and personal care products, these cookers can process up to 10,000 kg/hour, maintaining consistent quality and texture. Integrated automation with PLC systems ensures seamless production line integration and remote monitoring. Constructed with durable materials to resist corrosion, they meet strict GMP and FDA standards, with customization options available to match specific operational requirements. Maintenance is simplified with built-in CIP systems for efficient cleaning.

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Processes and Enhances Liquid and Slurry Products

The turnkey process plant from Perfinox delivers comprehensive solutions for food and beverage producers, seamlessly integrating into existing operations to handle diverse applications from ready meals to plant-based beverages. Specializing in batch and inline processing, the plant employs advanced mixing, blending, thermal, and aseptic processing technologies. Capable of customizable throughput rates, it features automation systems with PLC controls for optimal efficiency and remote monitoring, ensuring responsive operation and reduced energy usage. Built from corrosion-resistant stainless steel, it meets stringent hygiene standards, including CIP systems for effective cleaning. Perfinox offers engineering support for tailored configurations to suit specific production needs, catering to industries from dairy to winery applications.

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Stores and Maintains Sterility of Liquid Products

The PERFISAFE Aseptic Storage Tank from Perfinox is engineered for optimal storage in the food, beverage, and dairy sectors. This pressurized tank is designed for aseptic conditions, ensuring the sterility of liquids and slurry products. Capable of handling low to high viscosity materials, it integrates seamlessly into both batch and continuous operations. The tank offers multiple capacities starting from 20m³ and features options for vacuum and pressure design, making it highly adaptable to specific processing needs. Equipped with efficient CIP (Clean-In-Place) and SIP (Sterilize-In-Place) systems, it streamlines maintenance and reduces downtime. Constructed from high-grade materials, it withstands corrosive environments, ideal for storing products like apple puree, almond milk, or sparkling wine. Fully automated for seamless integration into existing production lines, this storage solution complies with stringent industry standards, making it a robust choice for maintaining product quality and safety.

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Processes and Cools Liquid and Slurry Products

The PERFITHERM from Perfinox is a vertical scraped surface heat exchanger adept for demanding food and beverage processing applications. It leverages a dual-jacketed vertical design to maximize heat exchange surfaces, enabling efficient heating, cooling, sterilizing, and pasteurizing processes. With capacities from 100 kg/hr to 10,000 kg/hr, this system integrates seamlessly into both batch and continuous production lines, managing operations like emulsifying and homogenizing for products ranging from soups to smoothies.

PERFITHERM’s unique advantage lies in its gentle product handling mechanism combined with advanced scrapers, reducing thermal degradation and maintaining product quality. Automated and designed for both CIP (Cleaning-in-Place) and SIP (Sterilization-in-Place), it ensures thorough, easy maintenance without disassembly. Equipped with a PLC control system, it supports remote monitoring and reduces energy consumption through optimized motor control.

Constructed with durable materials, the heat exchanger is suitable for handling liquid and slurry products like dairy, plant-based beverages, and fruit preparations, compliant with food industry standards. Customizable features, including temperature probes and motor shrouds, offer engineering flexibility to meet specific processing requirements.

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Processes and Sterilizes Food and Beverage Products

The PERFITHERM and PERFIPROCESS from Perfinox are versatile aseptic thermal processors engineered for food and beverage manufacturing. These systems feature scraped surface heat exchangers, ensuring gentle product handling and efficient heat transfer, making them ideal for applications that range from dairy concentrates and sauces to fruit smoothies and ready meal components. The processors can accommodate capacities from 300 to 3000 liters per hour, with adjustable flow and holding times that allow for extensive customization to meet specific production requirements. Integration into existing production lines is seamless, thanks to advanced PLC control systems that support continuous, batch, or inline operations. They boast energy efficiency through optimized motor controls and are constructed with hygienic design principles in mind, incorporating CIP/SIP systems for thorough, contamination-free cleaning. Available in corrosion-resistant materials, these processors are compliant with industry standards, ensuring safe, reliable, and efficient production across diverse uses.

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Dissolves Powders and Aseptically Cooks Liquids

The Cooqer 3 from Limitech A/S is an innovative industrial solution designed for efficient powder dissolution and aseptic cooking. Equipped with vacuum suction at the base, it swiftly integrates dry powders into liquids, achieving uniform blends. Perfect for processing food, beverage, and personal care products, it supports diverse applications including sauces, creams, vegan spreads, and more. Capable of both batch and continuous operation, Cooqer 3 ensures products do not burn during agitation, thanks to precision-engineered agitators. It features versatile cooking processes, such as direct steam injection and pressure cooking, while maintaining strict aseptic conditions to prevent contamination. Compact yet customizable in size, it integrates seamlessly with existing production lines, offering options for stainless steel construction to ensure durability and corrosion resistance. Easy to maintain with options for cleaning in place (CIP), the Cooqer 3 is a reliable choice for companies requiring superior quality and consistency in their production processes.

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Blows, Labels, Fills, and Caps Beverage Containers

The ErgoBloc L from Krones is an integrated solution combining stretch blow moulding, labelling, filling, and capping into one compact unit. Designed to transform your production line, this system excels in optimizing space with its block-synchronised design, reducing transport distances, and accommodating up to 100,000 containers per hour. Ideal for beverage manufacturers and PET bottle producers, it handles a variety of liquid products, from non-carbonated to carbonated beverages, including soft drinks, juices, and plant-based milk.

Powered by advanced infrared heating technology, it ensures precise control and minimal energy consumption, achieving up to 11% reduced energy usage compared to previous models. The Air Wizard Triple further cuts compressed air use by up to 20%, enhancing overall efficiency. Automating four core processes, the ErgoBloc L requires just one operator, guaranteeing seamless operation and shorter changeover times.

The system supports diverse container types—ranging from still water bottles to protein shake bottles—crafted with up to 100% recycled PET. Its fully-electronic PFR filling valve allows for infinitely variable control, while features like the “No bottle – no label” function reduce glue and label waste. Designed for extended operation, it integrates seamlessly into high-speed, automated production environments, proving indispensable in the beverage, food, and packaging industries.

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Processes and Preserves Liquid Dairy and Beverages

The VarioAsept M UHT system from Krones is engineered to exceed stringent hygiene requirements while preserving delicate liquid products. Designed for high-precision aseptic processing, this system is optimal for dairy and plant-based beverage production. It utilizes advanced tubular and plate heat exchangers developed by Krones experts to ensure gentle thermal treatment and is complemented by aseptic fillers, enabling a seamless integration into your production line.

With an output range between 3,500 and 60,000 liters per hour, VarioAsept M efficiently pasteurizes, homogenizes, deaerates, and sterilizes products such as UHT milk, almond milk, and flavored beverages. Its modular design includes components like buffer tanks and VarioSpin deaerators for stable, continuous operation even with upstream or downstream fluctuations.

This system supports both injection and infusion heating methods, offering flexibility for low to high-viscosity products. Its energy efficiency is enhanced by selective heating options and an optional rework tank that minimizes product waste. Automated via PLC and supported by Krones HMI, it allows for remote monitoring and optimization of production processes while ensuring low maintenance needs with CIP systems.

Constructed for durability, VarioAsept M provides options for various surface finishes to meet industry-specific requirements, ensuring compliance with relevant health and safety standards. Overall, this UHT system not only promises long production runs with minimized downtime but also offers customizable solutions to support your unique processing needs.

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