Filters, Dries, and Contains Hazardous Materials

The COMBER Pressofiltro® Series PF 50 – PF 2000 is an engineered solution from HEINKEL Group designed to meet rigorous industrial requirements for filtration and drying. Unique in its integration of an agitated Nutsche filter with a containment system, it addresses the high-stakes challenge of handling hazardous materials safely. Utilizing containment glove boxes, it ensures contamination-free product handling, crucial for maintaining purity in pharmaceutical ingredients and specialty chemicals.

The system supports operations such as batch or continuous processing for a variety of materials, including slurries and cakes. It features variable design capacities from 0.13 to 2 m² filter area and slurry volumes ranging from 55 to 2,000 liters. Engineered to adhere to cGMP and FDA guidelines, it employs HEPA-filtered air handling to maintain containment levels down to 10 ng/m³ TWA.

Constructed with high-grade materials like stainless steel and Hastelloy, it offers exceptional resistance to corrosive substances. The system’s automated features include a PLC-controlled interface, enabling seamless integration with existing production lines. Enhanced by options like dust filters, CIP systems, and vacuum units, the COMBER Pressofiltro® ensures both efficiency and safety in demanding applications.

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Performs Filtration, Drying, and Inspection

The COMBER Pressofiltro® Series PF 100 – PF 10000 is designed for multipurpose production facilities in pharmaceutical and chemical industries. Featuring a robust agitation mechanism for efficient slurry processing, it caters to the filtration and drying needs of APIs, specialty chemicals, and nutraceutical powders, ensuring precise moisture control. With a modular design, it accommodates a range of slurry volumes from 100 to 10,000 liters, offering seamless integration into both batch and continuous operations. Constructed with high-grade stainless steel and options for nickel-based alloys, it guarantees corrosion resistance, aligning with stringent cGMP and FDA standards. The system incorporates automated CIP processes for superior cleanability, minimizing contamination risk and downtime. The PLC-controlled unit is equipped with HMI touchscreens for intuitive operation and can integrate with DCS for enhanced process management.

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Filters, Dries, and Mixes Pilot-Scale Products

The COMBER Pressofiltro® / Turbodry® Series PF/TD units by Heinkel are versatile pilot plant filter and vacuum dryers designed for industries such as pharmaceutical, chemical, and food processing. Specially engineered to perform processes like filtration, drying, and mixing, they cater to operations that require small-scale production or pilot testing. This equipment is ideal for end-products like active pharmaceutical ingredients, epoxy resin powder coatings, and synthetic pigments.

Constructed in accordance with the Pressure Equipment Directive 97/23/EG and ASME U-stamp, these units are compliant with GMP and FDA guidelines, ensuring certification for pharmaceutical applications. They operate safely in ATEX danger zones (group II 2G 2D, zones 1/21) thanks to their explosion-protected control system (EEx-d). Built on a skid with a secure shaft seal via a gland nut, they support easy integration within existing production lines.

Customization is available, featuring a multilayer PLC system to enhance automation and process control. This series caters to Research & Development, laboratory, and processing departments seeking efficient filtration and drying of slurry and cake types. The equipment is also engineered for ease of maintenance with its robust design and materials suitable for a range of industrial environments.

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Performs Filtration, Drying, and Separation Operations

The MAVAZWAG® Agitated Nutsche Filters and Filter Dryers from GMM Pfaudler are versatile units designed for efficient batch operations in the pharmaceutical and chemical sectors. These systems excel in deep bed solid-liquid separation, using a specialized filter media to achieve comprehensive drying and discharge. Ideal for applications like antibiotics, APIs, and vaccine intermediates, MAVAZWAG® units integrate seamlessly into production lines with automation systems and CIP/SIP capabilities. Compact and adaptable, they are available in stainless steel, Hastelloy, and glass-lined options to ensure compatibility with corrosive environments. These units comply with GMP standards and offer advanced vacuum and solvent recovery systems, thus enhancing operational efficiency and safety. The unique “Clean Sweep” design facilitates total product discharge, while options for pilot unit testing ensure precise process optimization.

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Facilitates Mixing, Reaction, and Thermal Transfer

The Pharma Reactor from De Dietrich Process Systems is designed to enhance efficiency in biopharmaceutical and fine chemical production. It offers unique advantages such as optimized thermal transfer and high agitation performance thanks to the OptiMix® design. The reactor is versatile for producing monoclonal antibodies, APIs, and plant-based extractions. With a capacity range from 63 to 630 liters, it integrates seamless automation via CIP validation ensuring reliable cleaning and reduced downtime. Constructed with glass-lined covers and polished 316L stainless steel components, it offers excellent corrosion resistance and complies with GMP standards. Featuring advanced options like a fused glass quick release, the Pharma Reactor is engineered for flexibility, catering to specific requirements with customizable features and De Dietrich’s comprehensive engineering support.

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Filters and Dries Chemical Batches

The RoLab Pilot Scale Filter-Dryer from De Dietrich Process Systems is a versatile agitated nutsche filter-dryer designed for small-scale production and R&D environments. It excels in the manual filtration and drying of diverse chemical batches, ideal for handling solid, liquid, slurry, and cake. Key applications include pharmaceuticals, fine chemicals, and biopharmaceuticals, producing high-purity APIs, specialty polymers, and botanical extracts.

The RoLab’s mobile design and simplified installation make it suitable for pilot plant settings, allowing quick integration into existing lines with minimal setup—just connect the electrical, air, and heating systems. Its heated agitator and vessel ensure efficient drying, while the side discharge valve and gas knife system aid in complete product removal, adhering to cGMP and FDA guidelines.

The unit’s simplicity minimizes electronic interventions, reducing maintenance complexity. Available in various configurations, the RoLab offers engineering support for customization, ensuring optimal performance across various operations. Its efficient design not only supports frequent product changeovers but also ensures energy and resource efficiency, making it a cost-effective solution for laboratories, R&D centers, and production departments.

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Filters, Dries, and Extracts Solids from Liquids

The RoLab with Microwave from De Dietrich Process Systems is a versatile agitated Nutsche filter dryer. This equipment uniquely integrates microwave technology into the solid/liquid filtration and drying process, allowing for rapid reduction in drying times and enhanced energy efficiency. It operates under vacuum conditions, improving thermal processing through both conventional heating and microwave radiation, which penetrates deeply into the material for uniform drying—ideal for the pharmaceutical and fine chemical industries.

The RoLab is particularly effective for applications involving pharmaceuticals, plant extracts, and specialty chemicals, enhancing drying and extraction processes for products such as active pharmaceutical ingredients, intermediates, and herbal supplement powders. It can accommodate slurry, solid, liquid, and cake types, with a filter area of 0.4 m² and a maximum cake volume of 128 liters.

Designed for pilot, batch, and small-scale operations, the RoLab features reversible agitator speed control and an efficient 5.5 kW main motor. The microwave system operates at a frequency of 2.45 GHz, offering precise control over temperature and microwave power distribution, which reduces energy consumption and integrates seamlessly into your existing line. Constructed for durability and easy maintenance, the unit supports CIP requirements, ensuring contamination-free cleaning and minimal downtime.

Available in materials compatible with corrosive chemicals, the RoLab aligns with GMP standards, making it a reliable choice for labs and production facilities focused on quality and performance.

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Filters and Separates Solids from Liquids

Static Nutsche Filters from De Dietrich Process Systems are meticulously engineered for liquid-solid separation in pharmaceuticals and fine chemicals. Operating on a batch process, they use a robust filtration media at the base for high-throughput separation of slurries, yielding pure solids such as APIs and specialty polymers. These filters are suitable for vacuum or pressure applications ensuring reliability across critical reactions. Crafted from materials like QVF glass and Hastelloy, they offer excellent corrosion resistance, vital for handling sensitive compounds. The filters support compliance with GMP standards, making them ideal for regulated industries. Integration into production lines is seamless, with options for automation and remote monitoring. Customization is available to meet specific process requirements, and engineering support ensures optimal configuration to match your production needs.

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Processes Filtration, Washing, and Drying Operations

The Agitated Nutsche Filter-Dryer from De Dietrich Process Systems is an essential asset for pharmaceutical and chemical manufacturing, specializing in challenging solid-liquid separation tasks. It employs a multi-phase operation that expertly integrates filtration, washing, and drying into a closed system, crucial for purity-driven industries. This equipment supports applications such as the production of active pharmaceutical ingredients and biodegradable polymers, ensuring precise control over final product moisture levels. Featuring glass-lined and stainless steel options, it offers outstanding corrosion resistance, meeting stringent process conditions. It achieves seamless integration into existing production lines with PLC-controlled systems and CIP capability, reducing operator intervention and contamination risk. The system accommodates batch and continuous operations, adaptable to varied production scales, and is designed for compatibility with downstream processing steps. Compliance with industry standards ensures that it fits perfectly within regulated environments, fulfilling both efficiency and regulatory demands.

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Filters and Separates Biopharmaceutical and Chemical Components

The Glass Nutsche Filter from De Dietrich Process Systems is designed specifically for biopharmaceutical and fine chemical industries. This mobile filtration unit stands out with its corrosion-resistant glass construction, preventing any metal contact and ensuring product purity. It features a straightforward vacuum filtration process, ideal for R&D and pilot batch production. The QVF®-Nutsche Filter is equipped with an adjustable stirrer for smoothing the filter cake and incorporates a detachable filtrate chamber for easy product collection. Suitable for producing high-purity pharmaceutical intermediates, active ingredients, and specialty chemicals, it can handle batch operations efficiently. The transparency of the glass allows for visual process monitoring, while its smooth, pore-free surface facilitates easy cleaning, crucial for switching between products or meeting stringent contamination control standards. With integrated connections for ventilation and nitrogen, it promotes solvent efficiency and safety in handling volatile substances. The design also supports compliance with various industry standards, ensuring reliable and consistent results for fine chemical producers, pharmaceutical manufacturers, and R&D laboratories.

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