Microsphere process scale-up system for r&d
Enhance microsphere drug formulation with seamless scale-up capabilities, ensuring consistent quality and yield from research to production.
Refines and Processes Polymeric Microspheres
The LabMSR™ MicroSphere Refiner from Powder Systems Limited (PSL) is designed specifically for pharmaceutical and biotech advancements. This system tackles the intricacies of microsphere processing with its all-in-one functionality for classification, filtration, de-watering, washing, drying, discharge, and recovery. Ideal for producing controlled-release tablets, biodegradable implants, and targeted cancer therapies, it allows seamless transition from R&D to GMP production stages. With flexible vessel sizes and upgrade options, it supports diverse product types in both solid and liquid forms. The LabMSR™ integrates Process Analytical Technology (PAT) for real-time monitoring, ensuring consistent product quality and batch integrity. Its robust construction with optional stainless steel components meets stringent GMP and FDA standards, while the CIP and SIP capabilities facilitate easy maintenance and cleaning.
Benefits
- Facilitates seamless scale-up with precise control over production parameters.
- Enhances product yield by minimizing transfers and connections.
- Reduces development time with real-time PAT monitoring.
- Maintains batch consistency ensuring quality across scales.
- Supports diverse applications with its multi-product flexibility.
- Applications
- Polymeric microspheres,Drug delivery systems,Biopharmaceutical developments,Pharmaceutical formulations
- End products
- Bioresorbable stents,Injectable drug formulations,Biodegradable implants,Hormone delivery systems,Targeted cancer therapies,Controlled-release tablets
- Steps before
- Microspheres Synthesis,Polymeric Solution Preparation
- Steps after
- Sterilization,GMP Clinical Batch Production,Packing
- Input ingredients
- polymeric microspheres,microsphere batch,microsphere product development
- Output ingredients
- classified microspheres,washed microspheres,dried microspheres,product recovery,microsphere drugs,product yield
- Market info
- PSL (Powder Systems Limited) is known for designing and manufacturing advanced containment and process solutions for the pharmaceutical, biopharmaceutical, and chemical industries. They specialize in high-quality filtration, drying, and high containment systems.
- Vessel Size
- 0.01 Model
- Typical Product Cake Volume
- 0.25 – 0.40L
- Maximum Liquid Volume
- 2.10L
- Equipment Dimensions
- 1,340 x 1,030 x 1,750mm
- De-watering Method
- Suitable for Single Pass and Loop De-watering
- Filtration Step(s)
- Single Filtration (Refiner) / Dual Filtration (Scalper + Refiner)
- Drying Method
- Vacuum Drying and Freeze-Drying
- Automation level
- Manual / PLC / SCADA
- Batch vs. continuous operation
- Batch
- CIP/SIP
- CIP / SIP capable
- Cleaning method
- CIP / Manual
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Machine footprint
- 1,340 x 1,030 x 1,750 mm
- Vessel size
- 0.01 Model,0.25 – 0.40L typical product cake volume
- Maximum liquid volume
- 2.10L
- Discharge method
- Tilting vessel
- Multi-zone filtration
- Yes
- Multi-zone drying
- Yes
- CIP/SIP capability
- Yes,including steam-in-place
- Fully drainable design
- Yes
- Freeze-drying
- Capable
- Agitated vacuum drying
- Positive temperature
- Vessel sizes
- 0.01 Model
- Upgrade Options
- Standard LabMSR™
- De-watering Method
- Suitable for Single Pass and Loop De-watering
- Filtration Step(s)
- Single Filtration (Refiner) / Dual Filtration (Scalper + Refiner)
- Drying Method
- Suitable for Vacuum Drying and Freeze-Drying
- CIP/SIP
- SIP capable