Filters, Separates, and Extracts Liquids Efficiently

The Osmosys system from TMCI Padovan features advanced nanofiltration and reverse osmosis capabilities, suitable for diverse applications in wine, juice, dairy, and alcoholic beverage industries. This equipment is exceptional for its ability to efficiently extract water, hydroalcoholic solutions, acids, polysaccharides, and microorganisms, making it ideal for producing concentrated grape juice, low-alcohol wine, lactose-free milk, and distilled spirits.

The system utilizes spiral-wound membranes for superior separation and filtration, supporting both manual and fully automatic operations to meet varied production needs. With a configuration range from 2 to 32 modules, it accommodates throughput from 100 to 1,600 liters per hour, ensuring flexibility in processing capacity. Its energy-efficient design reduces consumption and operational costs, while the robust build offers material options resistant to corrosion, promoting longevity and reliability.

Osmosys integrates seamlessly into existing production lines, enhancing processing efficiency. It supports CIP systems for easy cleaning and complies with industry standards for safety and quality assurance. Engineered for customization, it can be tailored to specific production requirements, supported by TMCI Padovan’s expert engineering services.

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Controls and Optimizes Bioreactor Operations

The Single Use Bioreactor Control System offered by Marubishi Bioengineering is a customizable solution designed to seamlessly integrate into your biopharmaceutical production line, particularly when managing complex cell cultures and monoclonal antibody production. Its standout feature is the ability to tailor the control system according to your specific bioprocessing strategies, ensuring optimal performance and compliance with unique operational requirements.

This system excels in managing single-use bioreactors, commonly used in generating recombinant proteins and viral vectors intended for gene therapy. It supports continuous operations with an integrated SIP (Sterilization-In-Place) and CIP (Clean-In-Place) functionality to maintain sterility and operational efficiency.

Built for versatility, the system can manage various processing capacities, integrating smoothly with existing upstream and downstream processes. With a focus on energy efficiency, it incorporates advanced software for precise environment control, reducing energy consumption and system downtime.

Engineered from high-grade materials suitable for stringent biopharmaceutical conditions, it stands robust against potential corrosion, ensuring longevity and reliability. Certified to adhere to cGMP and FDA standards, this system is designed for the highest levels of compliance in the bioprocessing and life sciences industries.

For enhanced usability, it includes comprehensive support for system customization, remote monitoring, and flexible operational adjustments, ensuring it meets the varied demands of biotech and pharmaceutical applications.

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Facilitates Corrosion-Resistant Chemical Reactions and Mixing

The DIN Glass-Lined Reactors from GMM Pfaudler are engineered for superior corrosion-resistant processing in chemical, pharmaceutical, food, and energy sectors. These reactors follow the DIN 28136 standard, ensuring parts and components interchangeability among manufacturers, which minimizes downtime and dependency on single suppliers. Featuring standardized dimensions and interchangeable components like agitator support flanges, these reactors offer seamless integration with existing systems. They are versatile in applications such as reactions, absorption, distillation, and purification.

The DIN-AE, DIN-BE, and DIN-CE reactor types cater to different capacity needs, from 63 to 80,000 liters. DIN-BE reactors, the most widely used, provide a one-piece design with high pressure resistance and reduced leakage. Equipped with efficient mixing systems, they allow configurations up to seven stages for optimal process adaptation. Maintenance is streamlined with agitator replacements via the manway without extensive disassembly. Compliant with DIN EN ISO 28721-1, these reactors assure stringent enamel quality, meeting or exceeding industry standards. For easy maintenance, these reactors are customizable and supported by engineering expertise, ensuring tailored solutions for various processing demands.

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Performs Filtration, Drying, and Mixing Operations

The Filter Dryers MAVALAB from GMM Pfaudler offer a versatile, modular solution for pharmaceutical and chemical industries, prized for efficient solid-liquid separation and drying of active pharmaceutical ingredients and specialized chemical reagents. This mobile unit utilizes a hydraulic-free compact design, enhancing maneuverability in pilot plant settings or low volume production scenarios. Equipped with a purged double mechanical seal and a mechanical speed variator, the MAVALAB allows precise control over the filtration and drying processes, ensuring high-quality product output.

Common applications include laboratory chemical synthesis and pilot-scale drug formulation, addressing challenges in moisture removal and particle sizing. This pre-engineered unit supports integration within existing processing lines, suited for manual operation with full ATEX or NEMA compliant controls, ensuring safe use in explosive environments. The MAVALAB also features WIP/CIP devices for easy, contamination-free cleaning, and its construction in corrosion-resistant materials makes it ideal for handling aggressive substances. Additionally, the unit is adaptable to specific process conditions, backed by GMM Pfaudler’s engineering support for customization.

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Dries, Mills, and Mixes Sensitive Ingredients

The MAVADRY from GMM Pfaudler is a rotary vacuum paddle dryer specifically designed for pharmaceutical and chemical processing. It utilizes a heated airfoil blade with an integrated high-speed chopper, ensuring efficient drying and mixing of sensitive ingredients. With its high-torque hydraulic drive, the MAVADRY accommodates a wide range of filling capacities, making it ideal for producing active pharmaceutical ingredients, specialty fine chemicals, and biopharmaceuticals.

Operating under batch mode, it achieves precise moisture control and uniform drying through minimal clearance between the vessel wall and agitator, along with complete jacket coverage for enhanced heat transfer. The MAVADRY’s versatile design supports wet or dry chopping in combination with stator-assisted milling, enhancing particle size reduction and consistency.

Available in stainless steel, Hastelloy, and special alloys, it meets stringent cGMP and FDA guidelines, ensuring compatibility with sensitive applications. Maintenance is simplified with a hinged front door for easy access and inspection, while its compliance with pharmaceutical standards ensures reliability and safety in purification and final conditioning processes.

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Facilitates Separation and Purification Processes

The glass-lined steel columns from GMM Pfaudler are engineered to navigate the challenges of handling corrosive chemicals in the chemical, pharmaceutical, food, and energy industries. These columns are designed to support various separation and purification processes, including distillation, absorption, and evaporation. They stand out for their corrosion-resistant properties, utilizing a glass-lined steel construction that withstands harsh environments while ensuring product purity.

Integrating seamlessly into production lines, they accommodate custom-sized solutions and are optimized for continuous operations. These columns are particularly effective in the production of ultra-clean and ultra-pure chemicals, such as solvent recovery in the pharmaceutical sector and biofuel purification.

Processing capabilities are enhanced with options for jacketed or non-jacketed configurations, tailored nozzle locations, and various support mechanisms such as tantalum clad rings that meet stringent DIN 28007-2:2017-04 standards. The equipment is PLC-controlled, offering remote monitoring to ensure optimal operation and maintenance efficiency.

Available in multiple configurations, the columns can be combined with internals made from ceramic or PTFE from the Edlon product line, enhancing their adaptability to specific process requirements. GMM Pfaudler provides comprehensive engineering support, assisting with pilot testing and scale-up to ensure successful system integration.

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Processes Corrosive Chemicals and Pharmaceuticals Safely

The ASME RT, RS, RA, and RX series reactors from GMM Pfaudler are engineered to meet the rigorous demands of industries handling corrosive and sensitive materials. These glass-lined reactors offer unparalleled corrosion resistance, leveraging Pfaudler’s glass-lining expertise for enhanced safety in chemical, pharmaceutical, and food processing environments. The reactors feature multi-part or single-piece designs with options for Cryo-Lock technology, which facilitates internal assembly, especially beneficial for applications ranging from active pharmaceutical ingredient production to acid recovery and specialty chemical formulation.

With sizes spanning from 5 to 15,000 gallons, these reactors cater to diverse production scales. The inclusion of the INTERSEAL dry9000® sealing system ensures robust containment and lowers maintenance needs, while the choice of 316L stainless steel base metal in RX series extends their application to ultra-clean environments. Each reactor integrates seamlessly into existing production lines, equipped with advanced automation options and PLC capabilities to enhance efficiency and reduce operational downtime. These reactors are also compliant with ASME codes, providing assurance of safety and reliability in high-pressure scenarios.

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