Supports Cultivation and Optimizes Small-Scale Bioprocessing

The Applikon MiniBio is a compact, multi-use glass bioreactor designed for laboratory-scale applications, offering exceptional flexibility and efficiency for pharmaceutical and biotech operations. This autoclave-ready system minimizes media usage, optimizing bench space while supporting a range of processes, including cultivation, separation, mixing, and temperature control. Ideal for developing monoclonal antibodies, vaccines, probiotics, and enzymes, it offers true scalability from research to production phases. Equipped with a direct-drive system and optional integrated sensors for pH, DO2, and temperature, it ensures precise process control. The electrically cooled exhaust condenser reduces evaporation, enhancing operational efficiency. Customizable options include impeller and sparger configurations for versatile bioprocessing, all while aligning with GMP standards for assured quality and compliance.

The post Small size multi-use glass autoclavable bioreactor appeared first on Making.com.

Facilitates Parallel Bioprocess Development and Optimization

The DASbox® Mini Bioreactor from Eppendorf is designed for meticulous process development and optimization in biopharmaceutical and fine chemical manufacturing. Its industry-standard autoclavable glass vessel is equipped with a stainless steel head plate, enabling precise control with advanced sensors for temperature, pH, and dissolved oxygen. This bioreactor supports applications ranging from monoclonal antibody production to biofuel research, with a working volume of 60–250 mL, optimizing resource use and maintaining scalability. The direct overhead drive features either a marine or Rushton-type impeller, tailored for cell culture or microbial processes, respectively. Ideal for R&D and academic institutions, it allows parallel processing, reducing development time. Its liquid-free exhaust condenser facilitates easy operation with slide-in activation, ensuring simplicity in maintenance. No matter the application, the DASbox® Mini Bioreactor integrates seamlessly into a lab’s workflow, offering configurable options to meet specific project requirements.

The post Mini bioreactor for cell culture and microbial process development appeared first on Making.com.

Facilitates Cell Cultivation and Fermentation Processes

The BioFlo® 320 Bioreactor from Eppendorf is an engineered-to-order solution designed for complex bioprocessing needs. Featuring both glass and single-use vessel options with interchangeable magnetic and direct drive mechanisms, it supports cell cultivation and fermentation in R&D and industrial settings alike. Ideal for producing monoclonal antibodies, biofuels, and biopolymers, it accommodates batch, fed-batch, and continuous operations with working volumes ranging from 0.6 to 10.5 liters. The bioreactor’s autoclavable design includes a borosilicate glass body and stainless steel head plate, offering robust heat transfer capabilities or gentle temperature control via a water jacket. It integrates seamlessly with bioprocess controllers and supports various impeller designs, including Rushton and marine blades. The BioFlo® 320 is compliant with GMP standards, ensuring suitability for regulated environments, and features easy cleaning with interchangeable vessel designs. Customization options and engineering support are available to meet your unique process requirements.

The post Bioreactor for mammalian and microbial cell cultivation appeared first on Making.com.

Facilitates Scalable Cell and Microbial Cultivation

The DASGIP® Parallel Bioreactor System from Eppendorf revolutionizes bench-top bioprocessing by enabling parallel operation of up to 16 bioreactors for scalable cell culture and microbial fermentation. This innovative system integrates DASware software solutions for superior process control, automation, and data management, ideal for producing monoclonal antibodies, biosimilars, biofuels, and biopolymers. Capable of handling glass and single-use vessels, it supports diverse applications from stem cell culture to bioethanol production through customizable process parameters like pH, dissolved oxygen, and temperature control. Operating at a power consumption of 480 W (without DASGIP Bioblock), it ensures energy efficiency, while its modular design allows for flexible integration within existing R&D and production environments. The system is equipped with robust automation including TMFC gas mixing, adaptable feeding strategies, and CIP capabilities, providing streamlined, contamination-free operations. Designed to meet industry standards, it offers a range of material options suitable for various process chemistries and ensures easy maintenance with user-friendly control units, making it an indispensable solution for pharmaceutical manufacturers and biotechnology companies.

The post Parallel bioreactor system for cell culture and microbiology appeared first on Making.com.

Facilitates Fermentation and Cell Cultivation

The BRG Glass Bioreactor from Tofflon Life Science is expertly engineered for diverse bioprocess applications, including microbial fermentation and cell cultivation. Its design allows for customizable functionalities, making it ideal for biopharmaceutical and gene therapy production, including monoclonal antibodies and CAR-T cell therapies. The bioreactor supports scalable R&D and marketed production, while integrating seamlessly into automated workflows with options for PLC control and remote monitoring. Constructed from durable glass, the reactor ensures chemical compatibility and ease of observation during processes. It is suitable for use with a wide range of capacities, offering flexibility in experimental and production environments. Additionally, the BRG Glass Bioreactor adheres to GMP standards, supporting quality compliance and reliable outcomes in life science industries.

The post Glass bioreactor for microbial fermentation and cell cultivation appeared first on Making.com.

Facilitates Efficient Cell Culture and Fermentation

The HyPerforma™ Glass Bioreactor from Thermo Scientific is designed to meet the demanding needs of biopharmaceutical and biotechnology processes. This bioreactor stands out with its computational fluid dynamics-optimized impellers, ensuring maximal mixing efficiency with minimal shear, thus preserving cell viability. Ideal for applications ranging from monoclonal antibody production to gene therapy vector development, it is engineered for precision in both pilot and bench-top operations.

Constructed with borosilicate glass and 316L stainless steel, this bioreactor offers superior chemical resistance and durability. The innovative bidirectional control system allows seamless transition between mammalian cell culture and fermentation processes. Its ergonomic design simplifies assembly and maintenance, while the novel cooling loop guarantees superior thermal performance, reducing cooling times by 50% compared to similar models. Suitable for both cGMP and research laboratory environments, the HyPerforma™ Glass Bioreactor integrates effortlessly into existing production lines, enabling scalable and reproducible outcomes.

The post Glass bioreactor for mammalian cell culture appeared first on Making.com.

Cultivates and Ferments Biopharmaceutical Products

The HyPerforma Glass Bioreactor from Thermo Scientific is a versatile solution designed for the complex demands of biopharmaceutical production. Featuring a borosilicate glass body and 316L stainless steel components, it provides excellent chemical resistance and durability. This bioreactor excels in cultivating and fermenting cells to produce high-value end-products like monoclonal antibodies, recombinant proteins, and more. The unique design employs a CFD-optimized impeller system for superior mixing efficiency while minimizing shear stress, thereby protecting delicate cell lines. With capabilities to efficiently heat and cool, the bioreactor supports both mammalian and microbial fermentation processes. Its bidirectional control system adapts seamlessly to a range of production requirements, from pilot to full-scale cGMP operations. Additionally, the ergonomic headplate allows for rapid setup, minimizing downtime between runs. Fully compliant with industry standards, it is an ideal choice for CDMOs and biotech manufacturers seeking precision and reliability in their production lines.

The post Glass bioreactor for cell culture processes appeared first on Making.com.