Cryo-electron microscopy for high-resolution protein reconstruction
In structural biology, obtaining high-resolution protein structures is critical for understanding protein function and interaction. Traditional electron microscopy may face limitations in resolution and throughput, requiring enhanced imaging technologies.
Achieve high-resolution imaging with cryo-tem
The Tundra Cryo-TEM by Thermo Fisher Scientific is equipped for high-resolution protein reconstruction, featuring the Falcon C Direct Electron Detector. This detector uses electron-event representation (EER) for lossless data compression, ensuring efficient data storage without compromising spatial and temporal resolution. Designed for use at 100 kV, it provides superior image quality, high throughput, and enhanced detective quantum efficiency (DQE). The system’s large pixel size ensures a high signal-to-noise ratio (SNR), separating electron events from background noise. Additionally, the Tundra Cryo-TEM supports aberration-free image shift (AFIS) functionality to accelerate data collection, increasing image acquisition rates from 80 to 320 images per hour. Designed for users looking to perform detailed structural analyses, it integrates seamlessly with Thermo Scientific’s EPU Software for automated, user-friendly operation.
Benefits
- High-resolution imaging at 100 kV
- Lossless data compression with EER
- High signal-to-noise ratio
- Accelerated data collection with AFIS
- User-friendly operation with automated software