Mixes, Blends, and Homogenizes Powders and Solutions

The High Power Magnetic Mixer from Metenova is engineered to handle the rigorous demands of mixing powders and buffer solutions in biopharmaceutical and chemical production. This precision mixer excels in breaking down lump-forming powders and achieving rapid, uniform distribution in batch processes. Its robust construction incorporates Metenova’s Zero Gravity technology, ensuring a high level of aseptic operation and minimal maintenance requirements. Designed for non-shear sensitive products, the mixer supports applications in the creation of monoclonal antibodies, vaccines, APIs, and chemical intermediates.

Capable of integrating seamlessly into both pre-processing and processing lines, it offers significant flexibility with various vessel sizes and batch operations. The mixer head, crafted from durable, aseptic materials, enables high-speed operations, reducing energy consumption by utilizing a powerful motor. Available with stainless steel options, it guarantees chemical compatibility and corrosion resistance. For biopharmaceutical and chemical production, this equipment is compliant with GMP and FDA standards, promising high safety and performance. Simplified by its open design, it assures easy cleaning and maintenance through CIP/SIP compatibility, making it a critical tool for pharmaceutical manufacturers and chemical producers seeking reliable mixing solutions.

The post High power mixing solution for powder applications appeared first on Making.com.

Disperses and Emulsifies Aseptic Liquid Formulations

The Metenova HS Magnetic High Shear Mixer is engineered to meet the stringent demands of pharmaceutical and biotech industries, offering a fully aseptic solution for critical emulsions and dispersions. Utilizing Metenova’s patented Zero Gravity technology, this mixer provides an optimized balance between mixing and shearing, ensuring consistent particle size distribution critical for formulations like monoclonal antibodies and intravenous lipid emulsions. The magnetic rotor/stator design minimizes wear, leading to reduced maintenance and reliable uptime. Designed for batch operations, it integrates seamlessly into existing production lines, supporting both liquid and powder processes. The mixer excels in energy efficiency, helping reduce operating costs, while its robust construction ensures compatibility with aggressive chemical environments. Additionally, it complies with GMP standards, featuring CIP/SIP capabilities for effective, contamination-free cleaning. Customization options and engineering support are available to tailor the system to specific process requirements.

The post High shear mixer for emulsification appeared first on Making.com.

Mixes and Resuspends Biopharmaceutical Liquids

The Truelev Low Shear Magnetic Mixer from Metenova is engineered to address critical mixing needs in the biopharmaceutical, biotech, and chemical industries. Utilizing magnetic levitation technology, it ensures non-contact mixing, preventing contamination and enhancing product integrity. This mixer excels in applications such as vaccine solutions, monoclonal antibodies, and biologic drug formulations, providing efficient resuspension and emulsification. Designed for both batch and continuous operations, it integrates seamlessly into your production line with manual or automated controls. Constructed with corrosion-resistant materials, the Truelev Mixer meets rigorous GMP and FDA standards, making it ideal for cleanrooms and sterile environments. Its energy-efficient motor reduces operational costs, and optional CIP/SIP systems allow for swift and thorough cleaning between batches. Customization is available for specific processing requirements, supported by Metenova’s engineering expertise.

The post Single-use mixing solutions for downstream processes appeared first on Making.com.

Mixes and Emulsifies Aseptic Liquid Formulations

The Zero-g Magnetic Mixer from Metenova is designed to address the diverse mixing needs of pharmaceutical and biotech companies. This innovative solution operates using the patented Zero Gravity technology, allowing aseptic, contactless magnetic coupling for energy transfer and superior mixing. It is ideal for use in the production of monoclonal antibodies, vaccine formulations, and other sensitive biopharmaceutical processes. The Zero-g mixer supports both batch and continuous operations and integrates seamlessly into existing lines with its user-friendly design.

The high-performance impeller design ensures effective emulsification and gentle mixing, particularly suited for delicate operations like shear reduction in bioreactors. Built to FDA standards, it ensures compliance across various critical pharmaceutical and chemical applications. With minimal maintenance required due to its robust, wear-resistant design, the Zero-g is fully equipped with CIP/SIP capabilities for efficient cleaning. Available customization options ensure tailored integration and performance to meet specific production requirements.

The post Versatile magnetic mixer for pharmaceutical and biotechnology applications appeared first on Making.com.

Facilitates Gentle Aseptic Mixing in Bioreactors

The Zero-g Biomixer from Metenova is a magnetically coupled, bottom-mounted mixer specifically designed for aseptic and sterile bioreactor applications. Its patented Zero Gravity Technology features a magnetic bearing system that minimizes wear, ensuring reliable operation and reduced maintenance. This technology creates a magnetic cushion, allowing for gentle, efficient mixing with minimal risk of damage to impellers, making it well-suited for producing high-purity biologics, including monoclonal antibodies and DNA/RNA vaccines. The mixer supports customization of impeller designs to meet specific process requirements, reducing the need for revalidation. By eliminating mechanical seals, it enhances aseptic integrity, and its robust design withstands higher forces associated with large bioreactor vessels. Additionally, it is engineered for quick integration and minimized downtime with a focus on CIP/SIP (Cleaning-In-Place/Sterilization-In-Place) for contamination-free cleaning, supporting compliance with stringent industry standards like GMP and FDA.

The post Bioreactor mixer for gentle mixing applications appeared first on Making.com.

Facilitates Scalable Culturing and Fermentation Processes

The SUB Single Use Bioreactor System from Tofflon Life Science is engineered for efficient biopharmaceutical production, supporting processes like batch culture, feed culture, and perfusion. Its modular design ensures seamless scalability from pilot to large-scale production. Ideal for manufacturing monoclonal antibodies, cell therapies, and synthetic nanomedicines, it integrates with your upstream and downstream processes. Offering a single-use design, it enhances sterility and reduces contamination risks, aligning with GMP standards. Equipped with an intuitive control system, it facilitates precise environmental controls for optimal cell growth, while minimizing energy usage through optimized motor functions. Its compact design includes options for in-line mixing and sterile connections, ensuring flexibility and speed in dynamic production environments. Custom configurations are available to meet specific process requirements, and the system supports CIP applications for streamlined cleaning and maintenance.

The post Single use bioreactor for cell culture and fermentation appeared first on Making.com.

Expands and Amplifies Cell Cultures

The CES Cell Expansion System from Tofflon Life Science is engineered for scalable cell culture and seed amplification, pivotal in the production of biopharmaceuticals and vaccines. Utilizing rocking technology, this system ensures optimal mixing and ventilation, crucial for cell growth and expansion. It’s particularly effective in producing monoclonal antibodies, CAR T-cell therapy products, and stem cell-based treatments. The system’s single-use design minimizes contamination risks, ensuring a sterile environment, while supporting seamless integration into existing production lines. Capable of handling various cell types, it meets GMP standards, making it an ideal choice for pharmaceutical and biotech industries aiming for precision and reliability.

The post Cell expansion system for antibody drug production appeared first on Making.com.

Facilitates Fermentation and Cell Cultivation

The BRG Glass Bioreactor from Tofflon Life Science is expertly engineered for diverse bioprocess applications, including microbial fermentation and cell cultivation. Its design allows for customizable functionalities, making it ideal for biopharmaceutical and gene therapy production, including monoclonal antibodies and CAR-T cell therapies. The bioreactor supports scalable R&D and marketed production, while integrating seamlessly into automated workflows with options for PLC control and remote monitoring. Constructed from durable glass, the reactor ensures chemical compatibility and ease of observation during processes. It is suitable for use with a wide range of capacities, offering flexibility in experimental and production environments. Additionally, the BRG Glass Bioreactor adheres to GMP standards, supporting quality compliance and reliable outcomes in life science industries.

The post Glass bioreactor for microbial fermentation and cell cultivation appeared first on Making.com.

Mixes and Sterilizes Biopharmaceutical Process Fluids

The Thermo Scientific™ HyPerforma™ Single-Use Mixer DS 300 is engineered for the stringent demands of biopharmaceutical processes. Its stainless steel construction ensures robust and sterile operations, making it ideal for the preparation of monoclonal antibodies, vaccine formulations, and cell culture supplements. This mixer operates with precision through a variable speed range of 30-350 RPM, facilitating diverse tasks from hydration to sterile mixing in batch or high-throughput settings.

Equipped with a docking station featuring a vertical lift and motor mount, the HyPerforma DS 300 integrates seamlessly into existing production lines. The unit accommodates up to 300 liters, with options for both top and bottom-drain configurations, tailored to your specific processing needs. Its closed-system design significantly minimizes cross-contamination, aligning with GMP standards for pharmaceutical-grade applications.

Energy-efficient with a 15-amp power requirement, the mixer supports operational savings while maintaining high performance. Optional components like adjustable-angle motor heads and reusable bearing hubs provide further customization for enhanced process adaptation. Simplify your maintenance with integrated control systems designed for ease of use and effectiveness in bioprocessing environments.

The post Single-use mixer for buffer sterile mixing appeared first on Making.com.

Mixes and Homogenizes Sensitive Biopharmaceutical Formulations

The Flexsafe® Pro Mixer by Sartorius is an innovative single-use mixing solution tailored for pharmaceutical and biopharmaceutical applications. It features a levitating impeller that minimizes shear, protecting sensitive drug substances and proteins during homogenization and viral inactivation processes. This mixer supports various applications, including monoclonal antibody formulations, mRNA vaccines, and cell culture media development, making it versatile for both upstream and downstream operations. With its intuitive design, the Flexsafe® Pro Mixer allows for rapid installation and seamless integration into existing production lines, enhancing operational efficiency. It offers continuous inline control and monitoring of pH, conductivity, and temperature, ensuring precision in cGMP processes. The mixer operates with high energy efficiency due to optimized motor function and meets stringent GMP standards. Available with corrosion-resistant materials, it accommodates various process demands while simplifying cleaning and maintenance through a user-friendly design. Sartorius provides extensive customization options and engineering support, ensuring that the equipment meets specific production requirements effectively.

The post Single-use mixing system for biopharmaceutical production appeared first on Making.com.