Dries and Contains Sensitive Pharmaceutical Compounds

The CakeStand™ Vacuum Tray Dryer from Powder Systems Limited (PSL) is designed to address the critical drying needs of the pharmaceutical and chemical industries. This equipment features a fully sealed vacuum chamber and direct heating shelves, ensuring uniform drying with validated heating precision of +/-1°C. It is particularly suited for drying delicate pharmaceuticals like lyophilized drugs, chemotherapeutic agents, and hormone drugs, where sensitive handling is paramount.

This vacuum tray dryer is applicable across various environments, from clean rooms to containment isolators, and supports batch operations while allowing for manual product loading and unloading. Its capacity ranges with model configurations, offering scalable solutions from 0.18 to 13.0 m² of usable shelf area.

Engineered for cGMP compliance, the system boasts easy-to-clean metallic surfaces, strategically designed to minimize product traps. PSL’s automation platform supports pre-designed process recipes, enhancing flexibility and speed in production, with compliance to GAMP5 and 21 CFR Part 11 standards, ensuring robust data recording and electronic signature protocols.

Additionally, the CakeStand™ can integrate seamlessly into existing containment setups, whether as stand-alone equipment or wall-integrated within isolators, optimizing space and adhering to safety standards for handling potent APIs and HPAPIs. Its design consideration for operator ease and effective containment measures underlines PSL’s commitment to combining performance with safety.

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Performs Filtration, Drying, and Product Recovery

The GFD® Pilot Nutsche Filter Dryer from PSL is an engineered solution designed for precise solid-liquid separation and drying processes, essential in pharmaceuticals and fine chemicals. This compact, mobile unit excels at pilot and R&D scales by combining filtration and drying in one system, overcoming traditional challenges like inefficient recovery. Its agitated vessel works under vacuum and pressure, maximizing the yield of solids while ensuring thorough drying, facilitated by a heated jacket. The removable filtration basket allows easy product recovery and changeover for diverse applications, ranging from active pharmaceutical ingredients to specialty chemicals. Designed for flexibility, it supports multiple materials like Borosilicate 3.3 glass and 316L stainless steel to meet various chemical compatibility requirements. With hazardous area compliance options, including ATEX-certified pneumatic drives, it caters to solvent-based processes safely. It adheres to rigorous standards, complying with Pressure Directives and offering U-Stamp, PED, and SELO certifications. The GFD® Pilot ensures efficient operation within compact spaces like fume cupboards, enhancing its integration into existing systems. Optional GFD® FilterBox containment solutions safeguard both operators and products during handling of toxic materials, reinforcing its role in safe, high-yield production environments.

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Preserves and Protects Vacuum Pumps in Production

The MAXTRAP Vacuum Cold Trap from Cascade Sciences is engineered to extend the life of your vacuum pump by efficiently collecting condensates before they reach the pump. Uniquely designed with a COLDWELL stainless steel trap and a patent-pending baffle system, it prevents flow restriction and maximizes surface area for effective condensate capture. It operates using a mechanically refrigerated system built by Labconco and integrates seamlessly into laboratory and chemical processing lines, handling biopharmaceuticals, fine chemicals, and nutraceuticals, amongst other applications. With configurable refrigeration settings at -50°C and -105°C, it suits a variety of purging and drying tasks. Its robust construction includes a KF-25 inlet and outlet to ensure uninterrupted flow and minimal maintenance. The trap’s compliance with CFC and HFC-free standards underlines its commitment to operational safety and environmental responsibility.

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Preserves Vacuum Pumps Through Efficient Cold Trapping

The MAXTRAP Vacuum Cold Trap from Cascade Sciences is a lab-grade solution designed to enhance vacuum purging and drying operations for industries such as pharmaceuticals, biopharmaceuticals, and biotechnology. Its distinguishing feature lies in the patent-pending COLDWELL stainless steel trap with a series of filter baffles that maximize surface area, preventing your vacuum pump from ingesting unwanted materials. With versions capable of reaching -50°C and -105°C, the MAXTRAP efficiently handles high-throughput vacuum procedures and is critical for processes requiring precise control of gas and liquid product removal. It integrates seamlessly into existing production lines with full KF25 inlet and outlet connections, ensuring uninterrupted flow and reduced downtime. Featuring a mechanically refrigerated base by Labconco, the system utilizes eco-friendly refrigerants, supporting energy-efficient operations. Its robust construction also accommodates batch and continuous operations, making it suitable for processing gas and liquid product types, from vaccines to detergents. Cascade’s engineering expertise ensures that the MAXTRAP is compliant with stringent industry standards, backed by a one-year warranty for reliability and durability.

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Handles Aggressive Substances and Manages Vapor Outgassing

The Edwards nXDS Chemically Resistant Oil-Free Scroll Vacuum Pumps are engineered for challenging environments, offering a robust solution for handling corrosive or acidic substances. These pumps feature an oil-free design that reduces maintenance costs while ensuring minimal hydrocarbon emissions, crucial for sensitive lab environments. Utilizing a unique scroll compression mechanism, they efficiently manage vapor handling and outgassing, making them ideal for biopharmaceutical and chemical applications such as solvent recovery, gel drying, and thin film coatings. With models providing up to 25 CFM, they support a range of vacuum needs, from small research setups to larger industrial processes. Integration is streamlined with features like RS-232/485 control interfaces, allowing easy remote operation and monitoring. The pumps’ stainless steel components and Chemraz® valve technology ensure long-lasting resistance to aggressive chemicals, while their quiet operation at under 52 decibels minimizes environmental impact. These pumps offer extended operational life, recommended scroll changes every 40,000 hours, and are designed to meet rigorous cleanroom and high-energy physics standards. Options for customization and expert engineering support are available to meet specific operational needs, ensuring optimal performance in demanding conditions.

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Cleans and Disinfects Process Equipment and Pipelines

The Mobiclean™ from Pierre Guerin is a versatile Mobile Cleaning-In-Place unit designed to meet the rigorous sanitation demands of industries such as pharmaceuticals, food, dairy, and personal care. This unit stands out due to its modular design, offering a flexible solution that can be customized with various options like tank capacity, heating methods (electric or steam), and automatic detergent dosing systems. Its primary role is to efficiently clean and disinfect process vessels and piping networks, essential for maintaining high hygiene standards and product integrity. The Mobiclean™ supports both manual and optional automatic operations, allowing seamless integration into existing production setups. Its pre-mounted, pre-wired, and pre-tested skid design ensures rapid installation and commissioning, minimizing downtime. Constructed for easy use and low maintenance, the Mobiclean™ enhances productivity while meeting industry compliance standards for quality and safety.

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Emulsifies, Mixes, Heats, and Cools Medium-Scale Batches

The TURBO-MEK 25 – 1000 Series from Marchesini Group is a versatile vacuum turboemulsifier designed for medium-scale production in the cosmetics and personal care sectors. Specializing in processing liquid and creamy products, this equipment ensures consistent emulsification and mixing through its advanced system of slow mixers with counter-rotating movement and optional double-planetary blades. With a capacity ranging from 25 to 1000 liters, it effectively handles a variety of applications, including moisturizing lotions, skin serums, and pharmaceutical syrups.

Equipped with a tilting, jacketed vessel for precise heating and cooling utilizing electric resistances or steam, the TURBO-MEK guarantees optimal thermal management throughout the production process. Its vacuum circuit allows for controlled processing conditions, while pressure-assisted vessel emptying facilitates efficient product transfer. The stainless steel construction ensures durability and resistance to corrosion, complemented by an optional full Atex certification for enhanced safety.

Automation is enhanced with a 12” touchscreen interface and optional D-connect for remote service, enabling easy integration into batch processing lines and reducing downtime. Incorporating inverter-regulated speed control on both the turbine and mixers, this equipment minimizes energy usage, contributing to an environmentally-friendly manufacturing process. Additionally, optional ancillary melters and CIP readiness provide further customization and maintenance benefits, ensuring that the TURBO-MEK 25 – 1000 Series meets diverse production needs with reliability and precision.

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Processes and Emulsifies Liquid and Creamy Products

The TURBO-MEK 5 – 10 SERIES from the Marchesini Group’s Dumek brand is a vacuum turboemulsifier specifically crafted for laboratories, pilot plants, and small-scale production facilities in the cosmetics and personal care industries. This equipment excels in emulsification and mixing processes, operating with a turbine positioned at the vessel bottom and a slow mixer with counter-rotating movement. It is designed for precise control over liquid and creamy product formulations, such as shampoos, lotions, and facial creams. With a capacity of 5 or 10 liters, the mixer features an AISI 304 stainless steel base, a lifting lid, and a tilting vessel. It integrates a vacuum circuit and a vessel jacket for superior temperature control through heating and cooling. The 12” touchscreen interface facilitates easy operation and monitoring, and an optional D-connect app allows for remote service. The unit’s energy efficiency is enhanced by the inverter-controlled speed of both the turbine and slow mixer, ensuring precise, optimized processing for laboratory development and small-batch trials.

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Mixes and Granulates Diverse Materials Efficiently

The Ploughshare® Mixer from Gebrüder Lödige Maschinenbau is an engineered-to-order solution for efficient batch processing in sectors such as food, pharmaceuticals, and cosmetics. Known for its unique mixing mechanism, the Ploughshare® Mixer employs rotating mixing tools within a horizontally fitted cylindrical drum to create a three-dimensional movement of materials, resulting in precise mixing and granulation. This versatility extends to handling solids, powders, granules, and even liquids, catering to complex formulations like oven-ready flours, dietary supplements, and cosmetic compacts.

Capacities vary per model, with design optimization ensuring high throughput while minimizing dead zones through continuous material engagement. Integrated high-speed choppers further enhance the granulation process, breaking down agglomerates and distributing liquids uniformly. Customizable with heating or cooling jackets and engineered in various material grades—such as stainless steel for chemical resistance—the mixer meets industry-specific requirements including FDA approval and GAMP5 compliance. Maintenance is simplified with easy-to-clean designs and accessible components, supported by Lödige’s engineering expertise to tailor configurations—such as control systems and additional feeding methods—ensuring seamless integration into existing production lines.

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Processes and Mixes Diverse Industrial Materials

The Ploughshare® Mixer for batch operation from Gebrüder Lödige Maschinenbau GmbH offers unmatched versatility and precision in mixing, drying, and coating processes. Uniquely suited for industries such as chemical production and battery fabrication, it employs a horizontal mixing shaft that generates a mechanical fluid bed, effectively ensuring homogeneous mixing even with diverse material densities. Ideal for producing plasterboards, EPS granules, and lithium-ion battery cathode materials, this mixer handles solid, powder, and slurry types seamlessly. Its robust construction allows for additional choppers to increase turbulence and ensures efficient integration with existing production lines through PLC control systems. Further enhancing operational efficiency, the mixer is designed for minimal residue discharge and low maintenance, featuring wear-resistant components and options for ceramic or tungsten-carbide lining. Certified for various industry standards, it supports a clean-in-place (CIP) system for straightforward maintenance and effortless compliance with stringent industry regulations.

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