Processes and Refines Microspheres for Drug Delivery Systems

The MSR™ MicroSphere Refiner by Powder Systems Limited (PSL) is a comprehensive solution for pharmaceutical and biotechnology manufacturers focused on drug delivery via microspheres. This fully automated system integrates multiple stages of processing, including classification, filtration, de-watering, washing, drying, freeze-drying, sampling, and recovery. Designed for aseptic, batch operations, it addresses the challenge of handling valuable microspheric products by maximizing product recovery and maintaining batch consistency.

Featuring capabilities for both liquid and solid product types, the MSR™ accommodates various vessel sizes, with options supporting product cake volumes from 1.25 to 21.8 liters. The flexible design of the MSR™ supports multi-product applications, making it adaptable to rapidly changing production requirements. Enhanced process control is ensured through the integration of Process Analytical Technology (PAT), allowing for real-time quality monitoring and adherence to Good Manufacturing Practices (GMP), GAMP5, and 21 CFR Part 11 regulations.

The unit’s modular design supports seamless integration into existing pharmaceutical production lines, with vessel materials ensuring chemical compatibility and corrosion resistance. Maintenance is simplified via a Clean-In-Place (CIP) option, promoting contamination-free operations. The MSR™ is engineered for scalability, enabling a smooth transition from R&D to commercial production, ensuring critical process parameters are maintained throughout scale-up.

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Ensures Consistency and Stability in Liquid Products

The homogenizers from Priamo Food Technologies are engineered for exceptional performance in dairy and beverage production lines. Designed to tackle the challenge of achieving uniform particle distribution, these systems ensure consistency and stability across a wide range of liquid products such as milk, yogurt, cream, and various plant-based beverages. Capable of handling flow rates from 50 to 50,000 liters per hour at pressures up to 2,000 bar, they support high-speed, continuous operations. The equipment is built with stainless steel to withstand rigorous food and beverage processing conditions, adhering to EC standards for safe and reliable operations. Integration into existing lines is seamless, with PLC controls facilitating both automation and remote monitoring. These homogenizers not only improve product texture and shelf-life but also enhance energy efficiency with optimized motor control technology. Options for further customization and engineering support are available to tailor the systems to specific processing requirements.

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Processes Nanoemulsions and Reduces Particle Size

The Mini DeBEE from Pion is a high-pressure homogenizer designed for biotech and pharmaceutical applications, uniquely bridging R&D and small-scale production needs. Operating at pressures up to 45,000 PSI, it excels in producing nanoemulsions and uniform particle sizes, vital for effective liposomal vitamin C supplements and injectable insulin solutions. Handling up to 4.0 GPH, it integrates seamlessly into production lines with programmable pressure control and flow optimization. Its stainless steel construction ensures compatibility with rigorous industry standards, and it supports CIP for efficient cleaning. The unit’s scalability guarantees consistent results from laboratory to industrial settings, backed by comprehensive engineering support for customization.

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Processes Emulsions and Reduces Particle Size

The Nano DeBEE Gen II from Pion is a high-pressure benchtop homogenizer specifically engineered to meet the diverse needs of research and development environments in pharmaceutical, biotech, chemical, and food industries. This unit excels in particle size reduction, emulsification, and cell lysis, employing a modular emulsifying cell to allow flexible experimentation. With flow rates of 2 LPH and 6 LPH for varying demands, it supports low sample volumes as small as 12 mL, making it ideal for extensive laboratory applications ranging from liposomal encapsulation to DNA extraction. Equipped with PLC control for straightforward operation, it integrates seamlessly into laboratory processes, offering energy-efficient performance for liquid and slurry products. The unit is constructed with durable, corrosion-resistant materials, ensuring longevity and reliable operation.

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Processes and Encapsulates Liquids at High Pressure

The DeBEE 2000 from Pion is a high-pressure homogenizer designed for diverse applications within the pharmaceutical, biotech, chemical, food, and cannabis industries. It uniquely combines R&D versatility with pilot scale production capabilities, enabling effective processes such as cell disruption, particle size reduction, and nano-encapsulation. This system is ideal for creating protein therapeutics, liposomal encapsulated vitamins, and other intricate formulations, including cannabis-infused beverages. Capable of handling both liquids and slurries, the DeBEE 2000 ensures product consistency and quality with cGMP compliance and SCADA integration for real-time monitoring and control. It features a clean-in-place (CIP) system, simplifying maintenance while ensuring hygiene standards are maintained. With electronic signature compatibility and comprehensive data collection functionalities, this equipment supports stringent regulatory requirements. Pion provides customization options to meet specific production needs, backed by engineering support for seamless integration into your existing production line.

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Processes Nanoemulsions and Reduces Particle Size

The Micro DeBEE Laboratory High-Pressure Homogenizer from Pion is a versatile bench-top solution tailored for precise laboratory operations. This air-powered unit excels in processes such as cell lysis, nanoemulsions, particle size reduction, and dispersion, achieving industry-leading results with operating pressures up to 30,000 PSI. Designed for pharmaceuticals, biotech, and cosmetics, it aids in producing high-yield formulations like liposomal vaccines, protein therapeutics, and polymeric nanoparticles. With a flow rate of 15 LPH and requiring only clean, dry air for operation, it integrates seamlessly into your lab, offering no-assembly-required maintenance. Engineered for bioavailability enhancement and tighter particle distribution, it complies with laboratory standards while its small footprint and easy cleaning optimize workflow efficiency.

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Homogenizes and Emulsifies Liquid Products

The HP202 Bench-Top Homogenizer by OMVE stands out for its ability to precisely homogenize and emulsify a wide range of liquid products in lab-scale operations. Utilizing an inline high-pressure design, it facilitates two-stage homogenization without the need for pulsation dampers, ensuring smooth, consistent product texture. Suitable for industries like food and beverage, dairy, and nutraceuticals, it handles a production capacity of 10 to 50 liters per hour, making it ideal for research and development laboratories and pilot plants. This equipment integrates seamlessly with OMVE’s pasteurizer and sterilizer units, featuring automated flow-control and temperature sensors to maintain critical control points, all accessible via the human machine interface. Designed with minimum dead volume, the HP202 is CIP and SIP ready, ensuring easy cleaning and low maintenance. For operations requiring sterile environments, it offers an aseptic design upgrade. Additionally, OMVE provides a high level of automation and engineering support, assisting with customization to meet specific research needs.

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Homogenizes and Emulsifies Liquid Products

The HP303 Pilot Homogenizers from OMVE is a high-pressure inline solution expertly designed for food and beverage manufacturers seeking uniform product consistency and stability. Equipped with dual-stage homogenization valves and three plungers, it minimizes pulsation while ensuring precise emulsification and homogenization. With capacities ranging from 30L/h to 500L/h, the HP303 is perfectly suited for pilot operations.

This equipment excels in processing dairy, plant-based drinks, soups, and nutraceuticals, delivering tailored solutions across various liquid products like milk, yogurt, olive oil, and protein shakes. Full automation is facilitated by integration with HTST-UHT systems, providing seamless flow-control and temperature monitoring, essential for maintaining product quality.

OMVE’s HP303 is built for regulatory compliance, adhering to 3A standards, and utilizing FDA-approved elastomers. It supports CIP and SIP processes, ensuring rapid and effective cleaning. Whether you’re developing ice creams or crafting artisanal spirits, the HP303 offers the reliability and precision needed in high-pressure homogenization.

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Simulates Industrial-Scale Aseptic Processing

The HT220DSI UHT Direct Steam Injection Pilot Plant from OMVE offers an exceptional solution for R&D departments and food manufacturers looking to develop and refine plant-based beverages and dairy alternatives. This system employs a direct steam injection method coupled with a high-pressure homogenizer for precise pasteurization and sterilization. Ideal for producing oat milk, almond milk, soy milk, and more, it maintains product integrity while ensuring sterilization and aseptic filling. Handling capacities up to 1000L, it supports various configurations to suit specialized processes, including varying holding times. The fully automated system seamlessly integrates into existing setups, featuring PLC control for optimal production efficiency and remote monitoring. Designed with stainless steel materials, it ensures reliability and durability while meeting industry standards. Equipped with cleaning-in-place (CIP) and sterilizing-in-place (SIP) capabilities, it facilitates easy maintenance without contamination risk. OMVE also provides extensive customization to meet specific production needs.

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Cultivates and Optimizes Microbial and Cell Cultures

The Desk Top Fermentor from Marubishi Bioengineering offers a versatile solution for biotech and pharmaceutical applications, accommodating various cell types from microbes to mammalian cells. Its unique hollowed bottom end plate facilitates accurate temperature control through mild heating and rapid cooling, ensuring optimal fermentation conditions. With interchangeable vessel sizes up to 10 liters, it provides full-scale fermentation capabilities in a compact form. Tailored for precision, it includes top or bottom entry driving systems and multiple stirring impellers to cater to different culture processes, such as aerobic and anaerobic fermentations. Ideal for producing biologics, vaccines, and enzyme supplements, this fermentor features a user-friendly interface, integration with bioprocess controllers, and options for data logging via USB. The equipment is energy-efficient, utilizing mass flow controllers for aeration and precise agitation systems. Available in materials that resist corrosion, it is suitable for harsh processing environments. The fermentor conforms to industry standards for quality and safety, offering seamless integration into existing production lines and easing operational challenges through its modular design and easy maintenance. Customizable features include pressure handling up to 0.2MPa(G) and optional automation enhancements, ensuring optimal performance across diverse fermentation applications.

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