Controls High-Temperature High-Pressure Chemical Reactions

The Phoenix Flow Reactor from ThalesNano is a versatile solution designed for conducting high-temperature and high-pressure chemical reactions, ideal for pharmaceutical manufacturers, fine chemical producers, and research laboratories. This modular flow reactor stands out with its capacity to manage reactions up to 450°C and 200 bar, making it suitable for synthesizing complex compounds like active pharmaceutical ingredients (APIs) and specialty polymers. It integrates seamlessly with other instruments, thanks to its user-friendly software interface and modular design, allowing for easy customization and expansion. With options for PTFE, Hastelloy, and stainless-steel reactor materials, the Phoenix Flow Reactor ensures chemical compatibility and corrosion resistance. It features rapid heating and cooling capabilities, multiple temperature sensors for accurate monitoring, and supports both homogeneous and heterogeneous reactions. Whether you are conducting hydrogenation, oxidation, or carbonylation processes, this reactor accommodates your needs with efficiency and precision, making it an indispensable tool in high-demand research and production environments.

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Executes Precise Batch and Flow Photoreactions

The PhotoCube Photochemical Reactor System from ThalesNano is designed for laboratories specializing in complex chemical synthesis. This versatile system allows for precise control over batch and flow photoreactions, utilizing up to eight wavelengths for targeted applications. Ideal for producing Minisci reaction products and photoactivated pharmaceuticals, the PhotoCube operates between 20 and 80°C, with user-defined parameters for light intensity, wavelength, and stirring speed. It supports both fine chemical and pharmaceutical applications by efficiently merging multiple synthetic steps into a continuous flow process, significantly reducing reaction times and boosting yields. Constructed from materials such as FEP and PFA, it ensures chemical compatibility and durability. For energy efficiency, its LED input power reaches up to 128 W per color. Designed for seamless integration into existing R&D and laboratory environments, it offers optional external temperature control and built-in safety features to prevent light exposure. This reactor system is an essential tool for pharmaceutical manufacturers, research laboratories, and academic institutions aiming to push the boundaries of photochemical synthesis.

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Automates Liquid Sampling and Handling

The Brooks AIM4000 Autosampler, designed specifically for ThalesNano’s H-Cube® Pro, revolutionizes lab automation with its precise liquid sampling and handling capabilities. Integrating seamlessly with hydrogenation flow reactors, it facilitates the development of active pharmaceutical ingredients and custom chemical compounds. Its moving probe arm minimizes sample contamination while ensuring accurate sampling, which is crucial for achieving desired reaction outcomes.

Engineered for the pharmaceutical and chemical industries, this autosampler excels in small-scale and high-speed applications. It offers flexibility with customizable probe speeds and travel limits, adapting to varied laboratory needs. Compact and portable, the AIM4000 is chemically resistant and easy to maintain, supporting rigorous lab environments.

The AIM4000 enhances process automation, allowing efficient reaction sequences via an intuitive interface. As a result, you can focus on optimizing reaction conditions and accelerating research outcomes, with the reassurance of consistent performance and seamless operation.

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Generates and Mixes Hydrogen for Flow Reactions

The H-Cube® Pro Hastelloy from ThalesNano is a continuous flow hydrogenation reactor designed for researchers and manufacturers in the pharmaceutical and fine chemical industries. This reactor stands out for its on-demand hydrogen generation from water via electrolysis, eliminating the need for external hydrogen cylinders. Its unique design features Hastelloy C wetted parts, providing superior chemical resistance essential for handling corrosive reagents like mineral acids and bases, as well as oxidizing agents.

Operating within a temperature range of 10 to 150°C and a pressure range up to 100 bar, the H-Cube® Pro Hastelloy efficiently manages hydrogenation processes with fine control over reaction conditions such as pressure, temperature, and flow rate. The integrated microHPLC pump ensures accurate solvent delivery, which, when mixed with hydrogen, supports a stable reaction environment.

Ideal for producing active pharmaceutical ingredients, custom fine chemical compounds, and specialty polymers, this reactor accommodates reactions with variable scales from milligrams to grams. Its pre-packed CatCart® columns simplify catalyst handling, enhancing throughput and reducing downtime. Suitable for bench-top operations, this equipment is a versatile solution for R&D and processing departments seeking reliable performance in complex hydrogenation applications.

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Generates Hydrogen and Facilitates High-Pressure Chemical Reactions

The Phoenix-H-Genie Hydrogenation Platform from ThalesNano offers a cutting-edge solution for chemical and pharmaceutical sectors, enabling seamless hydrogenation processes without the need for external hydrogen supplies. By generating hydrogen through the electrolysis of water, this system ensures on-demand, safe production up to 1 NL/min at pressures of up to 100 bar. Designed with versatility in mind, it accommodates both homogeneous and heterogeneous catalysts, operating at temperatures reaching 450°C.

Its modular nature means you can tailor configurations for specific lab setups, with components such as HPLC pumps and mixer modules enhancing its capabilities. This platform is particularly valuable in producing synthetic fuels, pharmaceuticals, and specialty chemicals, supporting continuous and scalable operations. The integrated mass flow controller provides precise monitoring, optimizing both reaction conditions and efficiency. The use of self-fillable Catcarts enables catalyst testing and synthesis in varied quantities, making it ideal for fine chemical and pharmaceutical research. Configured from durable materials and offering easy maintenance, the Phoenix-H-Genie ensures long-lasting performance in demanding chemical environments.

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Facilitates Safe Catalyst Handling and Efficient Reactions

ThalesNano’s CatCarts® offer a unique catalyst handling system designed for flow chemistry applications, providing a safe and efficient way to manage heterogeneous catalysis with minimal user contact. These stainless-steel cartridges are packed with a solid catalyst and feature an integrated filtration system to ensure only the liquid substrate passes through, eliminating the need for catalyst filtration. Compatible with the H-Cube® series and Phoenix flow reactors, CatCarts® excel in hydrogenation reactions where precise control and high reaction rates are crucial.

They are ideal for industries ranging from pharmaceutical manufacturing to chemical research, facilitating the production of APIs, specialty chemicals, and selective hydrogenation compounds. CatCarts® are available in various sizes to match your specific chemistry needs and allow for quick catalyst exchange and reuse, reducing downtime and increasing productivity. The system’s design enhances phase interaction, boosting mass transfer and reaction speed while allowing seamless integration into existing production lines. Customize your CatCarts® with the desired catalyst through ThalesNano’s custom loading service, ensuring the perfect fit for your process requirements.

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Generates On-Demand Hydrogen for Catalytic Reactions

The H-Cube® Mini Plus from ThalesNano offers a unique solution for laboratory-scale continuous flow hydrogenation. This compact system generates hydrogen on-demand through water electrolysis, eliminating the need for stored gas cylinders. It supports a range of catalytic reactions crucial in pharmaceuticals, fine chemicals, and agrochemicals, such as the production of antihypertensive drugs and active pharmaceutical ingredients. With its ability to operate from atmospheric pressure to 100 bar and temperatures up to 100°C, the H-Cube® Mini Plus ensures precise control over reaction conditions. The system’s automation features include an integrated video tutorial, making it user-friendly for research and development departments. Adaptable across liquid, gas, and solid product types, it maintains energy efficiency with its controlled operation. The use of CatCart® cartridges simplifies catalyst handling and enhances safety. Configurable for various scales, it is optimal for both experimental and small-scale production needs.

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Generates and Mixes Hydrogen for Chemical Reactions

The H-Cube® Pro from ThalesNano combines electrolytic hydrogen generation with precise reactor control for seamless integration into laboratory-scale chemical synthesis. Using an on-demand electrolysis system, it safely generates up to 60 NmL/min of hydrogen gas, eliminating the need for external hydrogen cylinders and enhancing laboratory safety. The reactor is designed for pharmaceutical, fine chemical, and agrochemical applications, facilitating reactions such as hydrogenation, reduction, and deuteration. It offers scalability from milligram to gram-scale production, making it suitable for R&D and bench-top laboratory operations.

Equipped with user-friendly software, the H-Cube® Pro allows real-time monitoring and parameter adjustment, improving reaction control and efficiency. The system’s versatility is enhanced with additional modules, such as the Phoenix Flow Reactor, enabling operations up to 450°C for more complex synthesis routes. Its design minimizes energy and solvent consumption through efficient reaction parameters and customizable hydrogen flow rates. Suitable for use with a variety of gases beyond hydrogen, when connected to the Gas Module, it widens chemical capabilities significantly.

Constructed from corrosion-resistant materials, the H-Cube® Pro maintains robustness and reliability across a range of chemicals. Its compact design, combined with flexible automation options like integration with an Autosampler system, supports optimization studies and high-throughput screening with minimal manual intervention. With potential custom configuration and ongoing support, ThalesNano’s reactor system enhances productivity in laboratories needing high-precision, continuous flow chemistry solutions.

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