Making Liquid Dosage Forms
Find innovative production technology for making liquid dosage forms and connect directly with world-leading specialists.
Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.
Which liquid dosage forms technology do you need?
Laboratory liquid viewer for transparent glass bottles
Impurities like hair, fibers, or glass, sourced from the environmen…
Laboratory liquid viewer for varying light conditions
In the pharmaceutical industry, you must inspect liquids in vials or…
Laboratory liquid viewer for colored glass bottles
In the pharmaceutical industry, an inspection to detect any particulate…
Dilution system for two or more liquids in one pass
Onsite dilution of liquid process ingredients has historically been as…
Inline batch mixer for solids and liquids
Several issues often arise when your process requires batch-wise mixing of powder…
Manual stoppering equipment for pre-filled syringes
Air present in the empty space of pre-filled syringes may prevent you …
Manual ampoule filler
When you fill ampoules it is essential to avoid wetting the inside walls of the container, as it may aff…
Benchtop piston filling equipment for vials in trays
Vials are difficult to fill individually through manual methods due t…
Benchtop peristaltic dispenser
When you fill vials and ampoules, high standards of hygiene are required to avoid the risk of …
Start-up sterile filling line for ophthalmics
Commencing ophthalmic production requires sterile conditions and accurate met…
Sterile filling line for ophthalmics
Demanding very high standards, the ophthalmic market requires quality solutions for fil…
High-pressure homogenizer
When processes call for homogenized emulsions with extremely fine particle sizes the traditional to…
Agitator for medium viscosity media
Mixing fluids of medium viscosity for many production processes requires an agitator wit…
In-line laboratory dispersing machine
Innovators in a wide variety of industries need laboratory equipment on which processe…
Pilot dispersing machine for testing and scale-up
Innovators in process development need laboratory equipment that helps t…
Small-scale laboratory dispersing machine
Developing and validating new processes requires reliable and highly versatile eq…
Dust-free continuous homogenizing system
Producers in a wide variety of industries benefit from equipment that can continuou…
GMP homogenizing system
Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accura…
Batch dispersing machine for bottom entry into vessels
When your process requires high performance mixing or dispersion bu…
Continuous kneader
Effective mixing of highly viscous products with extremely high solids content can be difficult and the res…
High accuracy homogenizing system
When extremely high accuracy is required in your recipe or formulation traditional mixing …
Continuous homogenizing system
Certain mixing tasks present unique challenges and manufacturers need equipment that is specif…
Corundum disk mill
Wet milling and grinding of viscous liquids or pastes containing solid particles such as peanut butter,must…
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Dispersing machine for very fine emulsions and suspensions
For continuous high performance mixing of solid and liquid raw…
Economic dispersing machine for emulsions and suspensions
For products of medium viscosity and relatively consistent part…
Disposable tank liners
Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for thei…
Stickpack Machine
If you are looking to pack your product into stick packs from 17 x 40 mm to 100 x 200 mm in size, you may be…
Sachet Machine
If you want to pack into eye-catching 4-side sealed sachets between 40x50 mm and 250x200 mm in size, investing i…
Semi-automatic vial crimper
In a small production line, crimping vials manually can cause fatigue to your operator due to mul…
Benchtop ampoule opening and closing equipment
The procedure for opening or closing ampoules requires you to handle gas and…
Labeling machine for ampoules
It’s essential for pharmaceutical companies to provide the highest quality ampoules to custome…
Syrup preparation tank
Syrups and suspensions are typically produced under the same high-quality conditions as used for steril…
Bulk chamber washer
The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning and…
Entry-level chamber washer
When cleaning smaller products contacting filling or compressing components used in the production…
Loading basket for GMP washer
To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a way…
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Laboratory liquid viewer for transparent glass bottles
Impurities like hair, fibers, or glass, sourced from the environmen…
Laboratory liquid viewer for varying light conditions
In the pharmaceutical industry, you must inspect liquids in vials or…
Laboratory liquid viewer for colored glass bottles
In the pharmaceutical industry, an inspection to detect any particulate…
Dilution system for two or more liquids in one pass
Onsite dilution of liquid process ingredients has historically been as…
Inline batch mixer for solids and liquids
Several issues often arise when your process requires batch-wise mixing of powder…
Manual stoppering equipment for pre-filled syringes
Air present in the empty space of pre-filled syringes may prevent you …
Manual ampoule filler
When you fill ampoules it is essential to avoid wetting the inside walls of the container, as it may aff…
Benchtop piston filling equipment for vials in trays
Vials are difficult to fill individually through manual methods due t…
Benchtop peristaltic dispenser
When you fill vials and ampoules, high standards of hygiene are required to avoid the risk of …
Start-up sterile filling line for ophthalmics
Commencing ophthalmic production requires sterile conditions and accurate met…
Sterile filling line for ophthalmics
Demanding very high standards, the ophthalmic market requires quality solutions for fil…
High-pressure homogenizer
When processes call for homogenized emulsions with extremely fine particle sizes the traditional to…
Agitator for medium viscosity media
Mixing fluids of medium viscosity for many production processes requires an agitator wit…
In-line laboratory dispersing machine
Innovators in a wide variety of industries need laboratory equipment on which processe…
Pilot dispersing machine for testing and scale-up
Innovators in process development need laboratory equipment that helps t…
Small-scale laboratory dispersing machine
Developing and validating new processes requires reliable and highly versatile eq…
Dust-free continuous homogenizing system
Producers in a wide variety of industries benefit from equipment that can continuou…
GMP homogenizing system
Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accura…
Batch dispersing machine for bottom entry into vessels
When your process requires high performance mixing or dispersion bu…
Continuous kneader
Effective mixing of highly viscous products with extremely high solids content can be difficult and the res…
High accuracy homogenizing system
When extremely high accuracy is required in your recipe or formulation traditional mixing …
Continuous homogenizing system
Certain mixing tasks present unique challenges and manufacturers need equipment that is specif…
Corundum disk mill
Wet milling and grinding of viscous liquids or pastes containing solid particles such as peanut butter,must…
Dispersing machine for very fine emulsions and suspensions
For continuous high performance mixing of solid and liquid raw…
Economic dispersing machine for emulsions and suspensions
For products of medium viscosity and relatively consistent part…
Disposable tank liners
Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for thei…
Stickpack Machine
If you are looking to pack your product into stick packs from 17 x 40 mm to 100 x 200 mm in size, you may be…
Sachet Machine
If you want to pack into eye-catching 4-side sealed sachets between 40x50 mm and 250x200 mm in size, investing i…
Semi-automatic vial crimper
In a small production line, crimping vials manually can cause fatigue to your operator due to mul…
Benchtop ampoule opening and closing equipment
The procedure for opening or closing ampoules requires you to handle gas and…
Labeling machine for ampoules
It’s essential for pharmaceutical companies to provide the highest quality ampoules to custome…
Syrup preparation tank
Syrups and suspensions are typically produced under the same high-quality conditions as used for steril…
Bulk chamber washer
The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning and…
Entry-level chamber washer
When cleaning smaller products contacting filling or compressing components used in the production…
Loading basket for GMP washer
To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a way…
Small feeder with flexible wall hopper
In many laboratory applications and production processes, smaller quantities of powde…
Feeder with flexible wall hopper
The varying properties of dry powder products mean that specialized feeders are required for…
Agitator for low viscosity media
Reliably agitating fluids in open or pressure-less vessels in a laboratory or small scale pr…
Jet flow agitator for high-viscosity media
Processes including homogenization, dispersing, suspension, emulsification and d…
Laboratory dispersing machine for low-viscous masses
Laboratory mixers have not always been easy to work with. Getting al…
Cost-effective homogenizing and emulsifying system
Manufacturers of cosmetic products need mixing equipment that is capabl…
Batch dispersing machine for abrasive products
For mixing and dispersing tasks that cannot be completed by conventional sti…
Batch dispersing machine
Equipment operating under the rotor/stator principal is often employed when more traditional methods …
Vertical kneader
Production of highly viscous products with high solid content often benefits from kneading processes rather th…
Horizontal kneader
For high viscosity products, better results and reduced process times can be achieved with kneading type ra…
Cone mill machine
When your raw materials include agglomorated suspensions of grainy or crystalline solids and your process ne…
Colloid mill
For creating extremely fine emulsions and high quality dispersions a high pressure homogenizer is often chosen. T…
Ultra-fine dispersing machine for emulsions and suspensions
Producing the finest micro-emulsions and suspensions requires…
Dispersing machine for emulsions and suspensions
Equipment operating under the rotor/stator principal is often employed whe…
Small bottle checkweigher
Any small-diameter bottle, containing prescription medication or cosmetic applications, can be prop…
Versatile checkweigher
This Versatile checkweigher is equipped with a highly versatile strain gauge load cell. It is also suit…
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Use water or pure alcohol as a solution in the liquid dosage manufacturing process
The liquid dosage form is prepared by dissolving the active ingredient within a liquid vehicle to form a solution. Depending on the type of liquid vehicle used, you obtain either aqueous or non-aqueous solutions.
The aqueous solutions have water as the solvent, while the non-aqueous solutions have hydro-alcoholic (water and alcohol as solvents) and alcohol (only alcohol as solvent). Elixirs and tinctures are examples of hydro-alcoholic solutions. The concentration of alcohol in elixirs is 3%-25%, while the concentration of alcohol in tinctures is 25%-60%.
Apply size reduction to raw materials to facilitate solubility
Drops, syrups, elixirs, and draughts are monophasic liquid dosage forms, retaining the components in a single liquid phase. The APIs in most dosage forms of this type are weak acids or weak bases with low solubility properties. The formulation, therefore, requires adjustment of pH levels.
One method to improve solubility is by reducing the particle size of pharmaceutical powders. Using a mill or a spray drying system, grind the materials to 10 microns or less.
Apply gravimetric measurement in the liquid dosage manufacturing process
The volumetric measurement risks a high variability in liquids as the ingredients may be subjected to volume contraction or expansion.
The gravimetric method bypasses the effects of temperature and ambient forces acting on the ingredients. By measuring the density of the total contents, the technique gives a more reliable reading of the liquid dosage before filling and packing.