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Liquid dosage forms are a favorite of parents. And, with the right coloring and flavoring, they may be equally appreciated by children. The liquid dosage manufacturing process involves suspending active ingredients in a runny vehicle that facilitates absorption. From solutions to elixirs to sprays, liquid medicine formats provide easy dosing and produce a rapid medicinal response.

What liquid dosage forms equipment do you need?

Laboratory liquid viewer for transparent glass bottles

In the pharmaceutical industry, an inspection of liquids in vials ...

Benchtop peristaltic dispenser

When filling vials and ampoules, high standards of hygiene are required to avoid the risk of ...

Laboratory liquid viewer for colored glass bottles

In the pharmaceutical industry, an inspection to detect any particulat...

Manual ampoule filler

When filling ampoules is essential to avoid wetting the inside walls of the container, as it may affect...

Laboratory liquid viewer

Impurities like hair, fibers or glass, sourced from the environment, equipment or packaging can cont...

Manual stoppering equipment for pre-filled syringes

Air present in the empty space of pre-filled syringes may prevent the...

Semi-automatic vial crimper

In a small production line, crimping vials manually can cause fatigue to the operator due to mul...

Benchtop piston filling equipment for vials in trays

Vials are difficult to fill individually through manual methods due ...

Benchtop ampoule opening and closing equipment

The procedure for opening or closing ampoules requires the handling of gas ...

Small-scale laboratory dispersing machine

Developing and validating new processes requires reliable and highly versatile e...

Labeling machine for ampoules

It’s essential for pharmaceutical companies to provide the highest quality ampoules to custome...

Start-up sterile filling line for ophthalmics

Commencing ophthalmic production requires sterile conditions and accurate me...

Syrup preparation tank

Syrups and suspensions are typically produced under the same high-quality conditions as used for steri...

GMP washer

In order to guarantee zero cross-contamination between production batches, the proper cleaning of all product-conta...

GMP chamber washer

The thorough cleaning of small product contact parts has always been challenging, and traditional manual c...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a wa...

Portable IBC washer

The thorough cleaning of bulk containers and other storage and processing equipment is a vital step in th...

IBC bin washer and dryer

Many pharmaceutical processes use IBCs of multiple sizes throughout production. Careful washing and ...

CIP system for bulk tanks

Clean in Place (CIP) technology offers many advantages, but traditional systems are often inflexib...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning an...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing components used in the productio...

Feeder with flexible wall hopper

The varying properties of dry powder products mean that specialized feeders are required fo...

Small feeder with flexible wall hopper

In many laboratory applications and production processes, smaller quantities of powd...

Colloid mill

For creating extremely fine emulsions and high quality dispersions a high pressure homogenizer is often chosen.  ...

High-pressure homogenizer

When processes call for homogenized emulsions with extremely fine particle sizes the traditional t...

Stickpack Machine

If you are looking to pack your product into stick packs from 17 x 40 mm to 100 x 200 mm in size, you may b...

Sachet Machine

If you want to pack into eye-catching 4-side sealed sachets between 40×50 mm and 250×200 mm in size, ...

GMP homogenizing system

Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accur...

Sterile filling line for ophthalmics

Demanding very high standards, the ophthalmic market requires quality solutions for fi...

Corundum disk mill

Wet milling and grinding of viscous liquids or pastes containing solid particles such as peanut butter,mus...

Dispersing machine for emulsions and suspensions

Equipment operating under the rotor/stator principal is often employed wh...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Dispersing machine for very fine emulsions and suspensions

For continuous high performance mixing of solid and liquid ra...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Cone mill machine

When your raw materials include agglomorated suspensions of grainy or crystalline solids and your process n...

Inline batch mixer for solids and liquids

Several issues often arise when your process requires batch-wise mixing of powde...

Continuous homogenizing system

Certain mixing tasks present unique challenges and manufacturers need equipment that is speci...

High accuracy homogenizing system

When extremely high accuracy is required in your recipe or formulation traditional mixing...

Horizontal kneader

For high viscosity products, better results and reduced process times can be achieved with kneading type r...

Vertical kneader

Production of highly viscous products with high solid content often benefits from kneading processes rather t...

Continuous kneader

Effective mixing of highly viscous products with extremely high solids content can be difficult and the re...

Batch dispersing machine

Equipment operating under the rotor/stator principal is often employed when more traditional methods...

Batch dispersing machine for abrasive products

For mixing and dispersing tasks that cannot be completed by conventional st...

Batch dispersing machine for bottom entry into vessels

When your process requires high performance mixing or dispersion b...

Cost-effective homogenizing and emulsifying system

Manufacturers need production mixing equipment that is capable, flexib...

Dust-free continuous homogenizing system

Producers in a wide variety of industries benefit from equipment that can continuo...

Dilution system for two or more liquids in one pass

Onsite dilution of liquid process ingredients has historically been a...

Pilot dispersing machine for testing and scale-up

Innovators in process development need laboratory equipment that helps ...

In-line laboratory dispersing machine

Innovators in a wide variety of industries need laboratory equipment on which process...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

Jet flow agitator for high-viscosity media

Processes including homogenization, dispersing, suspension, emulsification and ...

Agitator for medium viscosity media

Mixing fluids of medium viscosity for many production processes requires an agitator wi...

Agitator for low viscosity media

Reliably agitating fluids in open or pressure-less vessels in a laboratory or small scale p...

Small bottle checkweigher

Any small-diameter bottle, containing prescription medication or cosmetic applications, can be pro...

Versatile checkweigher

This Versatile checkweigher is equipped with a highly versatile strain gauge load cell. It is also sui...

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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Use water or pure alcohol as a solution in the liquid dosage manufacturing process

The liquid dosage form is prepared by dissolving the active ingredient within a liquid vehicle to form a solution. Depending on the type of liquid vehicle used, you obtain either aqueous or non-aqueous solutions.

The aqueous solutions have water as the solvent, while the non-aqueous solutions have hydro-alcoholic (water and alcohol as solvents) and alcohol (only alcohol as solvent). Elixirs and tinctures are examples of hydro-alcoholic solutions. The concentration of alcohol in elixirs is 3%-25%, while the concentration of alcohol in tinctures is 25%-60%.

Apply size reduction to raw materials to facilitate solubility

Drops, syrups, elixirs, and draughts are monophasic liquid dosage forms, retaining the components in a single liquid phase. The APIs in most dosage forms of this type are weak acids or weak bases with low solubility properties. The formulation, therefore, requires adjustment of pH levels.

One method to improve solubility is by reducing the particle size of pharmaceutical powders. Using a mill or a spray drying system, grind the materials to 10 microns or less.

Apply gravimetric measurement in the liquid dosage manufacturing process

The volumetric measurement risks a high variability in liquids as the ingredients may be subjected to volume contraction or expansion.

The gravimetric method bypasses the effects of temperature and ambient forces acting on the ingredients. By measuring the density of the total contents, the technique gives a more reliable reading of the liquid dosage before filling and packing.

Control the hydrophilic-lipophilic balance when processing emulsions

Emulsions are formulations with two liquids that do not mix. These two main types of emulsion manufacturing are water in oil (W/O) emulsions and oil in water (O/W) emulsions.

Measuring the hydrophilic-lipophilic balance (HLB) presents a principal challenge in this liquid dosage manufacturing process. Emulsifiers with HLB values greater than 10 are more hydrophilic and thus better at stabilizing o/w emulsions. In contrast, emulsifiers with HLB values less than 10 are more hydrophobic and better suited for w/o emulsions.

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